Searching On:

Disease:

Gene:

ROS1, Gene Translocation

View:
Expand Collapse No disease selected  - General Description
Mass General Hospital Cancer Center treats patients with many cancer types. To learn more about the different cancer types that can be treated at the Cancer Center, please visit the Cancer Center website at the following page: http://www.massgeneral.org/cancer/services/
Expand Collapse ROS1  - General Description ROS1 is a gene that provides the code for making a protein, a receptor tyrosine kinase (RTK), that may activate several signaling pathways involved in the growth and division (proliferation), specialization (differentiation) and survival of cells. Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and a fast-growing type of central nervous system tumor, glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located. Source: Genetics Home ReferenceROS1 is a receptor tyrosine kinase (RTK) that activates several signaling pathways involved in proliferation, differentiation and survival of cells. Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located. Source: Genetics Home Reference
CLICK IMAGE FOR MORE INFORMATION
ROS1 is a gene that provides the code for making a protein, a receptor tyrosine kinase (RTK), that may activate several signaling pathways involved in the growth and division (proliferation), specialization (differentiation) and survival of cells.

Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and a fast-growing type of central nervous system tumor, glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located.

Source: Genetics Home Reference
ROS1 is a receptor tyrosine kinase (RTK) that activates several signaling pathways involved in proliferation, differentiation and survival of cells.

Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located.

Source: Genetics Home Reference
Expand Collapse Gene Translocation  in ROS1
PubMed ID's
22215748

Share with your Physican

Print information for your Physician.

Print information

Your Matched Clinical Trials

Trial Matches: (G) - Gene, (M) - Mutation
Trial Status: Showing all 4 results Per Page:
Protocol # Title Location Status Match
NCT00585195 A Study Of Oral PF-02341066, A c-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer A Study Of Oral PF-02341066, A c-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer MGH Open GM
NCT01970865 A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular Alterations A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular Alterations MGH Open GM
NCT02097810 Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations. Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations. MGH Open GM
NCT02279433 A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b MGH Open G
MGH has many open clinical trials for other cancers not shown on the Targeted Cancer Care website. They can be found on the MassGeneral.org clinical trials search page.

Additional clinical trials may be applicable to your search criteria, but they may not be available at MGH. These clinical trials can typically be found by searching the clinicaltrials.gov website.
Trial Status: Showing all 4 results Per Page:

Share with your Physican

Print information for your Physician.

Print information