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ROS1, Gene Translocation

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Mass General Hospital Cancer Center treats patients with many cancer types. To learn more about the different cancer types that can be treated at the Cancer Center, please visit the Cancer Center website at the following page: http://www.massgeneral.org/cancer/services/
Expand Collapse ROS1  - General Description ROS1 is a gene that provides the code for making a protein, a receptor tyrosine kinase (RTK), that may activate several signaling pathways involved in the growth and division (proliferation), specialization (differentiation) and survival of cells. Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and a fast-growing type of central nervous system tumor, glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located. Source: Genetics Home ReferenceROS1 is a receptor tyrosine kinase (RTK) that activates several signaling pathways involved in proliferation, differentiation and survival of cells. Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located. Source: Genetics Home Reference
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ROS1 is a gene that provides the code for making a protein, a receptor tyrosine kinase (RTK), that may activate several signaling pathways involved in the growth and division (proliferation), specialization (differentiation) and survival of cells.

Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and a fast-growing type of central nervous system tumor, glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located.

Source: Genetics Home Reference
ROS1 is a receptor tyrosine kinase (RTK) that activates several signaling pathways involved in proliferation, differentiation and survival of cells.

Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located.

Source: Genetics Home Reference
Expand Collapse Gene Translocation  in ROS1
Genetic alterations that occur in ROS1 involve a portion of (or the whole gene) breaking away from it's other half, or inserting itself in another part of the DNA where it doesn't normally belong. The gene fusion that results is a protein made up of part ROS1, and part of the protein that ROS1 inserted itself into. ROS1 Translocations result in the ROS1 protein being unregulated, as it is in normal cells, creating a constantly active ROS1 that sends growth and proliferation signals all the time, resulting in the development of cancer.
Genetic alterations that occur in ROS1 involve a portion of (or the whole gene) breaking away from it's other half, or inserting itself in another part of the DNA where it doesn't normally belong. The gene fusion that results is a protein made up of part ROS1, and part of the protein that ROS1 inserted itself into. ROS1 Translocations result in the ROS1 protein being unregulated, as it is in normal cells, creating a constantly active ROS1 that sends growth and proliferation signals all the time, resulting in the development of cancer.
PubMed ID's
22215748

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Your Matched Clinical Trials

Trial Matches: (G) - Gene, (M) - Mutation
Trial Status: Showing all 8 results Per Page:
Protocol # Title Location Status Match
NCT02279433 A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b MGH Open GM
NCT00585195 A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer MGH Open GM
NCT03093116 A Study of TPX-0005 in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements A Study of TPX-0005 in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements MGH Open GM
NCT02568267 Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) MGH Open GM
NCT02097810 Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations. Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations. MGH Open GM
NCT02927340 A Study of Lorlatinib in Advanced ALK and ROS1 Rearranged Lung Cancer With CNS Metastasis in the Absence of Measurable Extracranial Lesions A Study of Lorlatinib in Advanced ALK and ROS1 Rearranged Lung Cancer With CNS Metastasis in the Absence of Measurable Extracranial Lesions MGH Open G
NCT03052608 A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC MGH Open G
NCT02584634 Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101) Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101) MGH Open G
MGH has many open clinical trials for other cancers not shown on the Targeted Cancer Care website. They can be found on the MassGeneral.org clinical trials search page.

Additional clinical trials may be applicable to your search criteria, but they may not be available at MGH. These clinical trials can typically be found by searching the clinicaltrials.gov website.
Trial Status: Showing all 8 results Per Page:

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