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ROS1

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Mass General Hospital Cancer Center treats patients with many cancer types. To learn more about the different cancer types that can be treated at the Cancer Center, please visit the Cancer Center website at the following page: http://www.massgeneral.org/cancer/services/
Expand Collapse ROS1  - General Description ROS1 is a gene that provides the code for making a protein, a receptor tyrosine kinase (RTK), that may activate several signaling pathways involved in the growth and division (proliferation), specialization (differentiation) and survival of cells. Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and a fast-growing type of central nervous system tumor, glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located. Source: Genetics Home ReferenceROS1 is a receptor tyrosine kinase (RTK) that activates several signaling pathways involved in proliferation, differentiation and survival of cells. Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located. Source: Genetics Home Reference
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ROS1 is a gene that provides the code for making a protein, a receptor tyrosine kinase (RTK), that may activate several signaling pathways involved in the growth and division (proliferation), specialization (differentiation) and survival of cells.

Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and a fast-growing type of central nervous system tumor, glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located.

Source: Genetics Home Reference
ROS1 is a receptor tyrosine kinase (RTK) that activates several signaling pathways involved in proliferation, differentiation and survival of cells.

Changes in the ROS1 gene have been associated with non-small cell lung cancer (NSCLC) and glioblastoma multiforme. These changes are due to rearrangements of the chromosome where the gene is located.

Source: Genetics Home Reference
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The mutation of a gene provides clinicians with a very detailed look at your cancer. Knowing this information could change the course of your care. To learn how you can find out more about genetic testing please visit http://www.massgeneral.org/cancer/news/faq.aspx or contact the Cancer Center.

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Your Matched Clinical Trials

Trial Matches: (G) - Gene
Trial Status: Showing all 7 results Per Page:
Protocol # Title Location Status Match
NCT00585195 A Study Of Oral PF-02341066, A c-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer A Study Of Oral PF-02341066, A c-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer MGH Open G
NCT02568267 Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) MGH Open G
NCT01970865 A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular Alterations A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular Alterations MGH Open G
NCT02097810 Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations. Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations. MGH Open G
NCT02279433 A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b MGH Open G
NCT02927340 A Study of Lorlatinib in Advanced ALK and ROS1 Rearranged Lung Cancer With CNS Metastasis in the Absence of Measurable Extracranial Lesions A Study of Lorlatinib in Advanced ALK and ROS1 Rearranged Lung Cancer With CNS Metastasis in the Absence of Measurable Extracranial Lesions MGH Open G
NCT02584634 Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101) Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101) MGH Open G
MGH has many open clinical trials for other cancers not shown on the Targeted Cancer Care website. They can be found on the MassGeneral.org clinical trials search page.

Additional clinical trials may be applicable to your search criteria, but they may not be available at MGH. These clinical trials can typically be found by searching the clinicaltrials.gov website.
Trial Status: Showing all 7 results Per Page:

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