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FGFR1, Gene Amplification

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Mass General Hospital Cancer Center treats patients with many cancer types. To learn more about the different cancer types that can be treated at the Cancer Center, please visit the Cancer Center website at the following page: http://www.massgeneral.org/cancer/services/
Expand Collapse FGFR1  - General Description FGFR1 is a gene that provides the code for making a cell surface protein called fibroblast growth factor receptor 1 (FGFR1). When bound to specific growth factors (proteins that stimulate cell growth and division), it activate a signaling system inside the cell that ultimately controls diverse functions such as the development of the nervous system and regulation of large bone growth. In certain types of stomach and prostate cancers, there is an excess of FGFR1 produced in the cancer cells (overexpression). The excessive signaling that results from the extra receptors may make it easier for the cancer cells to grow, divide, and move. Unusual expression of the FGFR1 gene is also found in certain pancreatic, esophageal, ovarian, testicular, breast and head and neck cancers. Source: Genetics Home ReferenceFGFR1 is a gene that provides the code for making a protein called fibroblast growth factor receptor 1. This receptor is located on the surface of cells. When certain growth factors (proteins that stimulate cell growth and division) come into contact with (bind to) this receptor, they activate a signaling system within the cell that tells it to undergo certain changes. In its normal role, the FGFR1 protein is believed to help the nervous system develop, and it also may help regulate the growth of long bones. In certain types of stomach and prostate cancers, the FGFR1 gene makes too make of the receptor (overexpression). The excessive signaling that results from the extra receptors may make it easier for the cancer cells to grow, divide and move. Unusual expression of the FGFR1 gene is also found in certain pancreatic, esophageal, ovarian, testicular, breast and head and neck cancers. Source: Genetics Home Reference
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FGFR1 is a gene that provides the code for making a cell surface protein called fibroblast growth factor receptor 1 (FGFR1). When bound to specific growth factors (proteins that stimulate cell growth and division), it activate a signaling system inside the cell that ultimately controls diverse functions such as the development of the nervous system and regulation of large bone growth.

In certain types of stomach and prostate cancers, there is an excess of FGFR1 produced in the cancer cells (overexpression). The excessive signaling that results from the extra receptors may make it easier for the cancer cells to grow, divide, and move. Unusual expression of the FGFR1 gene is also found in certain pancreatic, esophageal, ovarian, testicular, breast and head and neck cancers.

Source: Genetics Home Reference
FGFR1 is a gene that provides the code for making a protein called fibroblast growth factor receptor 1. This receptor is located on the surface of cells. When certain growth factors (proteins that stimulate cell growth and division) come into contact with (bind to) this receptor, they activate a signaling system within the cell that tells it to undergo certain changes. In its normal role, the FGFR1 protein is believed to help the nervous system develop, and it also may help regulate the growth of long bones.

In certain types of stomach and prostate cancers, the FGFR1 gene makes too make of the receptor (overexpression). The excessive signaling that results from the extra receptors may make it easier for the cancer cells to grow, divide and move. Unusual expression of the FGFR1 gene is also found in certain pancreatic, esophageal, ovarian, testicular, breast and head and neck cancers.

Source: Genetics Home Reference
Expand Collapse Gene Amplification  in FGFR1
Amplification of a gene occurs when a region of DNA that contains a gene is duplicated. Gene amplification is one of many ways in which a gene can be overexpressed.
Amplification of a gene occurs when a region of DNA that contains a gene is duplicated. Gene amplification is one of many ways in which a gene can be overexpressed.

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Your Matched Clinical Trials

Trial Matches: (G) - Gene, (M) - Mutation
Trial Status: Showing all 2 results Per Page:
Protocol # Title Location Status Match
NCT01948297 Debio 1347-101 Phase I Trial in Advanced Solid Tumours With Fibroblast Growth Factor Receptor (FGFR) Alterations Debio 1347-101 Phase I Trial in Advanced Solid Tumours With Fibroblast Growth Factor Receptor (FGFR) Alterations MGH Open GM
NCT02052778 A Dose Finding Study Followed by a Safety and Efficacy Study in Patients With Advanced Solid Tumors or Multiple Myeloma With FGF/FGFR-Related Abnormalities A Dose Finding Study Followed by a Safety and Efficacy Study in Patients With Advanced Solid Tumors or Multiple Myeloma With FGF/FGFR-Related Abnormalities MGH Open G
MGH has many open clinical trials for other cancers not shown on the Targeted Cancer Care website. They can be found on the MassGeneral.org clinical trials search page.

Additional clinical trials may be applicable to your search criteria, but they may not be available at MGH. These clinical trials can typically be found by searching the clinicaltrials.gov website.
Trial Status: Showing all 2 results Per Page:

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