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Pertuzumab

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Expand Collapse Pertuzumab  - General Description A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis.
Drug Short Name
MOAB 2C4
Synonyms
2C4; 2C4 antibody; monoclonal antibody 2C4; rhuMAb2C4; rhuMAb-2C4
US Brand Names
Perjeta
A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis.
Drug Short Name
MOAB 2C4
Synonyms
2C4; 2C4 antibody; monoclonal antibody 2C4; rhuMAb2C4; rhuMAb-2C4
US Brand Names
Perjeta

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Your Matched Clinical Trials

Trial Matches: (D) - Drug
Trial Status: Showing all 1 result Per Page:
Protocol # Title Location Status Match
NCT02326974 T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA MGH Open D
MGH has many open clinical trials for other cancers not shown on the Targeted Cancer Care website. They can be found on the MassGeneral.org clinical trials search page.

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