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Nexavar

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Expand Collapse Nexavar  - General Description sorafenib tosylate
The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.
Chemical Name
2-pyridinecarboxamide, 4-[4-[[[[4-chloro-3- trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate tosylate
Drug Code Name
BAY 54-9085
Drug Short Name
SFN
Synonyms
BAY 43-9006
BAY 43-9006 Tosylate Salt
US Brand Names
Nexavar
sorafenib tosylate
The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.
Chemical Name
2-pyridinecarboxamide, 4-[4-[[[[4-chloro-3- trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate tosylate
Drug Code Name
BAY 54-9085
Drug Short Name
SFN
Synonyms
BAY 43-9006
BAY 43-9006 Tosylate Salt
US Brand Names
Nexavar

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