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CH5424802

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Expand Collapse CH5424802  - General Description alectinib
An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor CH542480 binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. 
Drug Code Name
AF802
CH542802
RG7853
RO5424802
UNII-LIJ4CT1Z3Y
Synonyms
ALK inhibitor CH5424802
anaplastic lymphoma kinase inhibitor CH5424802
alectinib
An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor CH542480 binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. 
Drug Code Name
AF802
CH542802
RG7853
RO5424802
UNII-LIJ4CT1Z3Y
Synonyms
ALK inhibitor CH5424802
anaplastic lymphoma kinase inhibitor CH5424802

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