Clinical Trial - NCT03539536

Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer

Recruiting

Sponsor: AbbVie

Collaborators:

Information provided by (Responsible party): Sponsor

ClinicalTrials.gov Identifier: NCT03539536

Protocol Info

Short Description: Phase 2 Telisotuzumab Vedotin in Previously Treated C-MET+ NSCLC
Long Description: Phase 2, Open-Label Safety and Efficacy Study of Telisotuzumab Vedotin (ABBV-399) in Subjects with Previously Treated c-Met+ Non-Small Cell Lung Cancer
MGH Status: Closed
Sponsor: AbbVie
Disease Program: Thoracic

Next Steps


If you are interested in this protocol or in other treatment options at Massachusetts General Hospital, please Request a Consultation.




Purpose

This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage 2).
Condition Title Intervention Phase
Non-small Cell Lung Cancer Telisotuzumab vedotin Phase 2
Study Type Interventional
Official Title Phase 2, Open-Label Safety and Efficacy Study of Telisotuzumab Vedotin (ABBV-399) in Subjects With Previously Treated c-Met+ Non-Small Cell Lung Cancer

Primary Outcome Measures

Overall Response Rate (ORR) [Time Frame: Up to approximately 3 years] [Designated as safety issue: ]


Secondary Outcome Measures

Duration of Response (DoR) [Time Frame: Up to approximately 3 years] [Designated as safety issue: ]

Disease Control Rate (DCR) [Time Frame: Up to approximately 3 years] [Designated as safety issue: ]

Progression-Free Survival (PFS) [Time Frame: Up to approximately 3 years] [Designated as safety issue: ]

Overall Survival (OS) [Time Frame: Up to approximately 3 years] [Designated as safety issue: ]

Estimated Enrollment: 233
Study Start Date: October 2018
Estimated Study Completion Date: January 2025
Estimated Primary Completion Date: January 2025
Arms Assigned Interventions

Experimental:Telisotuzumab vedotin

Telisotuzumab vedotin administered via intravenous (IV) infusion every 14 days.
Drug:Telisotuzumab vedotin
Intravenous (IV) infusion

Eligibility

Ages Eligible for Study: N/A-N/A

Genders Eligible for Study: All

Accepts Healthly Volunteers: No

Inclusion Criteria:

  • Histologically confirmed non-squamous cell non-small cell lung cancer (NSCLC) with known epidermal growth factor receptor (EGFR) status (wild type or mutant; with site documented status). Of note, participants with other actionable mutations are eligible as long as EGFR status is known and all other eligibility criteria are met.
  • Has locally advanced or metastatic NSCLC.
  • Has c-Met+ NSCLC as assessed by an AbbVie designated immunohistochemistry (IHC) laboratory. Participant must submit archival or fresh tumor material for assessment of c-Met levels during the pre-screening period. If archival tissue is c-Met negative, participant can submit fresh biopsy material for reassessment of c-Met expression.
  • Have received no more than 2 lines of prior systemic therapy (including no more than 1 line of systemic cytotoxic chemotherapy) in the locally advanced or metastatic setting.
  • Multiple lines of tyrosine kinase inhibitors (TKIs) targeting the same gene alteration count as 1 line of therapy for the purposes of this eligibility criterion.
  • Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1.

Exclusion Criteria:

  • Have received prior c-Met-targeted antibody-based therapies.
  • Has adenosquamous histology.
  • Participants with metastases to the central nervous system (CNS) are eligible only after definitive therapy (such as surgery or radiotherapy).
  • Has a clinically significant condition(s) described in the protocol.
  • Has unresolved clinically significant adverse events >= grade 2 from prior anticancer therapy, except for alopecia or anemia.
  • Had major surgery within 21 days prior to the first dose of telisotuzumab vedotin.
  • Has received live vaccine within 30 days of the first dose of telisotuzumab vedotin.
  • History of interstitial lung disease or pneumonitis that required treatment with systemic steroids, or any evidence of active interstitial lung disease or pneumonitis.
  • Known active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
  • Participants do not have any evidence of pulmonary fibrosis on screening imaging assessment or any history of pneumonitis or interstitial lung disease within 3 months of the planned first dose of the study drug.
  • Participants must not have received radiation therapy to the lung <6 months prior to the first dose of telisotuzumab vedotin.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT03539536

Locations

  • United States, Alabama
    • University of South Alabama /ID# 212939 Mobile, Alabama, United States, 36604-3302
  • United States, Arizona
    • Mayo Clinic Arizona /ID# 218550 Phoenix, Arizona, United States, 85054-4504
  • United States, Arkansas
    • Highlands Oncology Group /ID# 215600 Springdale, Arkansas, United States, 72762
  • United States, California
    • University of California, Los Angeles /ID# 203219 Los Angeles, California, United States, 90095
    • LA Hematology-Oncology Med Group /ID# 203338 Orange, California, United States, 92868
    • Sutter Medical Center Sacramen /ID# 203299 Sacramento, California, United States, 95816
    • Icri /Id# 227835 Whittier, California, United States, 90603
  • United States, Colorado
    • Univ of Colorado Cancer Center /ID# 203212 Aurora, Colorado, United States, 80045
    • Rocky Mountain Cancer Centers, LLP- Sky Ridge /ID# 215789 Lone Tree, Colorado, United States, 80124
  • United States, Florida
    • Mayo Clinic - Jacksonville /ID# 218488 Jacksonville, Florida, United States, 32224
    • University of Miami, Miller School of Medicine /ID# 221247 Miami, Florida, United States, 33136
    • AdventHealth Cancer Institute - Orlando /ID# 215649 Orlando, Florida, United States, 32804
  • United States, Hawaii
    • Straub Clinic and Hospital /ID# 217905 Honolulu, Hawaii, United States, 96813-3097
  • United States, Illinois
    • Northwestern University Feinberg School of Medicine /ID# 203239 Chicago, Illinois, United States, 60611-2927
    • The University of Chicago Medical Center /ID# 203216 Chicago, Illinois, United States, 60637-1443
    • NorthShore University HealthSystem - Evanston Hospital /ID# 215583 Evanston, Illinois, United States, 60201
    • Ingalls Memorial Hosp /ID# 203228 Harvey, Illinois, United States, 60426
    • Joliet Oncology-Hematology Associates, LTD /ID# 203238 Joliet, Illinois, United States, 60435
  • United States, Indiana
    • Goshen Center for Cancer Care /ID# 215584 Goshen, Indiana, United States, 46526
  • United States, Kansas
    • Univ Kansas Med Ctr /ID# 216804 Kansas City, Kansas, United States, 66160
    • Cancer Center of Kansas /ID# 203235 Wichita, Kansas, United States, 67214
  • United States, Kentucky
    • Baptist Health /ID# 203283 Lexington, Kentucky, United States, 40503-1463
    • Norton Cancer Institute /ID# 203284 Louisville, Kentucky, United States, 40207
  • United States, Maine
    • Central Maine Medical Center /ID# 216583 Lewiston, Maine, United States, 04240
  • United States, Massachusetts
    • Massachusetts General Hospital /ID# 203215 Boston, Massachusetts, United States, 02114
    • Beth Israel Deaconess Medical Center /ID# 208124 Boston, Massachusetts, United States, 02215-5400
    • Dana-Farber Cancer Institute /ID# 203248 Boston, Massachusetts, United States, 02215
  • United States, Michigan
    • Henry Ford Hospital - West Bloomfield /ID# 203220 West Bloomfield, Michigan, United States, 48322
  • United States, Minnesota
    • Mayo Clinic /ID# 215603 Rochester, Minnesota, United States, 55905-0001
  • United States, Mississippi
    • Hattiesburg Clinic /ID# 227691 Hattiesburg, Mississippi, United States, 39401
  • United States, Missouri
    • St. Lukes Cancer Institute /ID# 227697 Kansas City, Missouri, United States, 64111-5905
    • Washington University-School of Medicine /ID# 203217 Saint Louis, Missouri, United States, 63110
  • United States, Montana
    • St. Vincent Frontier Cancer Center /ID# 203292 Billings, Montana, United States, 59102
  • United States, New Hampshire
    • Dartmouth-Hitchcock Medical Center /ID# 203350 Lebanon, New Hampshire, United States, 03756
  • United States, New Jersey
    • Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 228868 East Brunswick, New Jersey, United States, 08816
    • Atlantic Health System /ID# 203404 Morristown, New Jersey, United States, 07960-6136
    • Overlook Medical Center /ID# 211160 Summit, New Jersey, United States, 07901-3533
  • United States, New Mexico
    • University of New Mexico /ID# 208339 Albuquerque, New Mexico, United States, 87102-4517
  • United States, Ohio
    • Univ Hosp Cleveland /ID# 215648 Cleveland, Ohio, United States, 44106
  • United States, Oklahoma
    • Mercy Research Mercy Clinic Oklahoma Communities, Inc. / OKC OK /ID# 230154 Oklahoma City, Oklahoma, United States, 73120
  • United States, Oregon
    • Providence Cancer Center Oncology and Hematology Care - Westside Portland /ID# 203301 Portland, Oregon, United States, 97225
  • United States, Pennsylvania
    • Penn State University and Milton S. Hershey Medical Center /ID# 221844 Hershey, Pennsylvania, United States, 17033-2360
    • Allegheny General Hospital /ID# 215585 Pittsburgh, Pennsylvania, United States, 15212
    • Veterans Healthcare System /ID# 215602 Pittsburgh, Pennsylvania, United States, 15240
  • United States, Tennessee
    • Thompson Cancer Survival Ctr /ID# 228874 Knoxville, Tennessee, United States, 37916
    • Cancer Care at Vanderbilt-Ingram Cancer Center /ID# 203281 Nashville, Tennessee, United States, 37232-6307
  • United States, Texas
    • Houston Methodist Hospital - Scurlock Tower /ID# 213268 Houston, Texas, United States, 77030
    • Baylor Scott & White Medical Center- Temple /ID# 216578 Temple, Texas, United States, 76508-0001
  • United States, Virginia
    • Virginia Cancer Specialists /ID# 203224 Fairfax, Virginia, United States, 22031
  • United States, Washington
    • University of Washington /ID# 206056 Seattle, Washington, United States, 98109-1024
  • United States, Wisconsin
    • Medical College of Wisconsin /ID# 210062 Milwaukee, Wisconsin, United States, 53226-3522
  • Australia, New South Wales
    • The Kinghorn Cancer Centre /ID# 207666 Darlinghurst, New South Wales, Australia, 2010
    • Newcastle Private Hospital /ID# 206600 Lambton Heights, New South Wales, Australia, 2305
    • The Tweed Hospital /ID# 206601 Tweed Heads, New South Wales, Australia, 2485
  • Australia, Queensland
    • Mater Misericordiae Limited /ID# 229639 South Brisbane, Queensland, Australia, 4101
  • Australia, Western Australia
    • St John Of God Subiaco Hospital /ID# 226943 Subiaco, Western Australia, Australia, 6008
  • Belgium,
    • UZ Antwerp /ID# 217430 Edegem, , Belgium, 2650
    • AZ Groeninge /ID# 217431 Kortrijk, , Belgium, 8500
  • Bulgaria,
    • MHAT Dobrich /ID# 230074 Dobrich, , Bulgaria, 9300
    • Medical Center Nadezhda /ID# 230473 Sofia, , Bulgaria, 1339
  • Canada, Alberta
    • Cross Cancer Institute /ID# 204540 Edmonton, Alberta, Canada, T6G 1Z2
  • Canada, Ontario
    • The Ottawa Hospital /ID# 205579 Ottawa, Ontario, Canada, K1H 8L6
    • Princess Margaret Cancer Centre /ID# 204423 Toronto, Ontario, Canada, M5G 2M9
  • Canada, Quebec
    • CISSS de la Monteregie /ID# 211356 Greenfield Park, Quebec, Canada, J4V 2H1
  • China, Anhui
    • Anhui Provincial Hospital /ID# 212096 Hefei, Anhui, China, 230001
  • China, Fujian
    • Fujian Provincial Cancer Hospital /ID# 210808 Fuzhou, Fujian, China, 350014
  • China, Hebei
    • Affiliated Hospital of Hebei University /ID# 227262 Baoding, Hebei, China, 071000
  • China, Henan
    • Henan Cancer Hospital /ID# 210961 Zhengzhou, Henan, China, 450008
  • China, Jiangsu
    • The First People's Hospital of Changzhou /ID# 210787 Changzhou, Jiangsu, China, 213003
  • China, Jilin
    • Jilin Cancer Hosptial /ID# 210563 Changchun, Jilin, China, 130000
  • China, Shanghai
    • Fudan University Shanghai Cancer Center /Id# 210084 Shanghai, Shanghai, China, 200032
  • China, Xinjiang
    • The Affiliated Cancer Hospital of Xinjiang Medical university /ID# 227244 Urumqi, Xinjiang, China, 830000
  • China, Zhejiang
    • The First Affiliated Hospital, College of Medicine, Zhejiang University /Id# 211154 Hangzhou, Zhejiang, China, 310003
    • Zhejiang Cancer Hospital /ID# 210085 Hangzhou, Zhejiang, China, 310022
  • China,
    • Beijing Cancer Hospital /ID# 210133 Beijing, , China, 100142
    • West China Hospital, Sichuan University /ID# 210022 Chengdu, , China, 610041
    • Chongqing University Cancer Hospital /ID# 231507 Chongqing, , China, 400030
    • Shanghai Chest Hospital /ID# 210930 Shanghai, , China, 200030
  • Czechia,
    • Vseobecna Fakultni Nemocnice /ID# 229797 Prague, , Czechia, 128 08
    • NH Hospital a.s. /ID# 228953 Praha, , Czechia, 155 00
  • France, Bouches-du-Rhone
    • CHU Hopital Nord /ID# 209854 Marseille, Bouches-du-Rhone, France, 13915
  • France, Gironde
    • Institut Bergonie /ID# 216207 Bordeaux, Gironde, France, 33000
  • France, Ile-de-France
    • Institut Curie /ID# 207046 Paris CEDEX 05, Ile-de-France, France, 75248
  • France, Rhone
    • Centre Leon Berard /ID# 205107 Lyon CEDEX 08, Rhone, France, 69373
  • France, Val-de-Marne
    • Centre Hosp Intercommunal de Creteil /ID# 227108 Creteil, Val-de-Marne, France, 94000
    • Institut Gustave Roussy /ID# 205149 Villejuif Cedex, Val-de-Marne, France, 94805
  • France,
    • Hopital Louis Pradel /ID# 216209 Bron, , France, 69500
    • CHRU de Lille - Hopital Albert Calmette /ID# 205105 Lille, , France, 59037
    • Nouvel Hopital Civil (NHC) /ID# 208080 Strasbourg, , France, 67091
  • Germany, Baden-Wuerttemberg
    • Universitatsklinikum Mannheim /ID# 228798 Mannheim, Baden-Wuerttemberg, Germany, 68167
  • Germany, Sachsen-Anhalt
    • Krankenhaus Martha-Maria Halle-Doelau /ID# 205442 Halle (Saale), Sachsen-Anhalt, Germany, 06120
  • Germany,
    • Vivantes Klinikum Neukoelln /ID# 205928 Berlin, , Germany, 12351
    • Asklepios Fachkliniken Muenchen-Gauting /ID# 207789 Gauting, , Germany, 82131
    • Evangelisches Krankenhaus Hamm /ID# 208043 Hamm, , Germany, 59063
    • Klinikum Kassel /ID# 205443 Kassel, , Germany, 34125
    • Pius-Hospital Oldenburg /ID# 211615 Oldenburg, , Germany, 26121
  • Greece, Attiki
    • General Hospital of Chest Diseases of Athens SOTIRIA /ID# 205528 Athens, Attiki, Greece, 11527
    • Metropolitan Hospital /ID# 205529 Piraeus, Attiki, Greece, 18547
  • Greece,
    • University General Hospital of Heraklion PA.G.N.I /ID# 205530 Heraklion, , Greece, 71110
    • Bioclinic Thessaloniki /ID# 227261 Thessaloniki, , Greece, 54622
    • Euromedica General Clinic /ID# 227264 Thessaloniki, , Greece, 54645
  • Hungary, Borsod-Abauj-Zemplen
    • CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 204878 Miskolc, Borsod-Abauj-Zemplen, Hungary, 3529
  • Hungary, Pest
    • Torokbalinti Tudogyogyintezet /ID# 204883 Budapest, Pest, Hungary, 2045
  • Hungary,
    • Semmelweis Egyetem /ID# 204434 Budapest, , Hungary, 1085
    • Veszprem Megyei Tudogyogyintez /ID# 213950 Farkasgyepu, , Hungary, 8582
    • Matrahaza Gyogyintezet /ID# 204432 Kékesteto, , Hungary, 3233
  • Ireland, Dublin
    • St. James's Hospital /ID# 205104 Dublin 8, Dublin, Ireland, D08 E9P6
  • Ireland,
    • Cork University Hospital /ID# 205103 Cork, , Ireland, T12 E8YV
    • Mater Misericordiae University Hospital /ID# 231466 Dublin 7, , Ireland, D07 R2WY
    • St Vincent's University Hosp /ID# 205102 Dublin, , Ireland, D04 T6F4
    • University Hospital Limerick /ID# 229873 Limerick, , Ireland, V94F858
  • Israel, HaDarom
    • Soroka Medical Center /ID# 204898 Be'er Sheva, HaDarom, Israel, 84101
  • Israel,
    • Rambam Health Care Campus /ID# 204866 Haifa, , Israel, 3109601
    • Meir Medical Center /ID# 204255 Kfar Saba, , Israel, 4428164
    • Rabin Medical Center /ID# 215322 Petakh Tikva, , Israel, 4941492
    • Sheba Medical Center /ID# 204254 Ramat Gan, , Israel, 5239424
  • Italy, Emilia-Romagna
    • A.O.U. Policlinico S.Orsola-Malpighi /ID# 216153 Bologna, Emilia-Romagna, Italy, 40138
    • IRST IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori /ID# 205601 Meldola, Emilia-Romagna, Italy, 47014
  • Italy, Lazio
    • Policlinico Universitario Campus Bio-Medico /ID# 215918 Rome, Lazio, Italy, 00128
    • Azienda Ospedaliera San Camillo Forlanini /ID# 205163 Rome, Lazio, Italy, 00152
  • Italy,
    • AO San Giuseppe Moscati /ID# 204707 Avellino, , Italy, 83100
    • A.O.U. San Luigi Gonzaga /ID# 204706 Orbassano, , Italy, 10043
    • Azienda Ospedaliero Uni Parma /ID# 204983 Parma, , Italy, 43100
    • IFO Istituto Nazionale Tumori /ID# 227011 Rome, , Italy, 00144
  • Japan, Aichi
    • Aichi Cancer Center Hospital /ID# 207790 Nagoya-shi, Aichi, Japan, 464-8681
  • Japan, Fukuoka
    • National Hospital Organization Kyushu Cancer Center /ID# 206061 Fukuoka-shi, Fukuoka, Japan, 811-1395
    • Kurume University Hospital /ID# 227776 Kurume-shi, Fukuoka, Japan, 830-0011
  • Japan, Hyogo
    • Himeji Medical Center /ID# 227777 Himeji-shi, Hyogo, Japan, 670-0012
  • Japan, Kanagawa
    • Kanagawa Cancer Center /ID# 205068 Yokohama-shi, Kanagawa, Japan, 241-8515
  • Japan, Mie
    • Matsusaka Municipal Hospital /ID# 230219 Matsusaka-shi, Mie, Japan, 515-8544
  • Japan, Miyagi
    • Sendai Kousei Hospital /ID# 216460 Sendai-shi, Miyagi, Japan, 980-0873
  • Japan, Niigata
    • Niigata Cancer Center Hospital /ID# 216462 Niigata-shi, Niigata, Japan, 951-8566
  • Japan, Okayama
    • Okayama University Hospital /ID# 227851 Okayama-shi, Okayama, Japan, 700-8558
  • Japan, Osaka
    • Osaka International Cancer Institute /ID# 210735 Osaka-shi, Osaka, Japan, 541-8567
    • Kinki-Chuo Chest Medical Center /ID# 216461 Sakai-shi, Osaka, Japan, 591-8555
  • Japan, Shizuoka
    • Shizuoka Cancer Center /ID# 205065 Sunto-gun, Shizuoka, Japan, 411-8777
  • Japan, Tokyo
    • National Cancer Center Hospital /ID# 205066 Chuo-ku, Tokyo, Japan, 104-0045
    • The Cancer Institute Hospital Of JFCR /ID# 216463 Koto-ku, Tokyo, Japan, 135-8550
  • Japan, Yamaguchi
    • Yamaguchi - Ube Medical Center /ID# 227778 Ube-shi, Yamaguchi, Japan, 755-0241
  • Japan,
    • Hiroshima Citizens Hospital /ID# 218087 Hiroshima, , Japan, 730-8518
  • Korea, Republic of, Gyeonggido
    • National Cancer Center /ID# 204241 Goyang, Gyeonggido, Korea, Republic of, 10408
    • Seoul National University Bundang Hospital /ID# 204237 Seongnam, Gyeonggido, Korea, Republic of, 13620
    • The Catholic University Of Korea St. Vincent's Hospital /ID# 229647 Suwon, Gyeonggido, Korea, Republic of, 16247
  • Korea, Republic of,
    • Chungbuk National Univ Hosp /ID# 205680 Cheongju, , Korea, Republic of, 28644
    • Chonnam National University Hwasun Hospital /ID# 206951 Jeonnam, , Korea, Republic of, 58128
    • Asan Medical Center /ID# 204236 Seoul, , Korea, Republic of, 05505
    • Samsung Medical Center /ID# 227083 Seoul, , Korea, Republic of, 06351
  • Netherlands, Noord-Holland
    • Antoni van Leeuwenhoek /ID# 216657 Amsterdam, Noord-Holland, Netherlands, 1066 CX
  • Netherlands,
    • Meander Medisch Centrum /ID# 217756 Amersfoort, , Netherlands, 3813 TZ
    • Ziekenhuis St. Jansdal /ID# 216658 Harderwijk, , Netherlands, 3844 DG
  • Poland, Lodzkie
    • Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej /ID# 231476 Lodz, Lodzkie, Poland, 90-549
  • Poland, Mazowieckie
    • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 230595 Warsaw, Mazowieckie, Poland, 02-781
  • Poland, Wielkopolskie
    • Med Polonia Sp. z o. o. /ID# 229908 Poznan, Wielkopolskie, Poland, 60-693
  • Puerto Rico,
    • VA Caribbean Healthcare System /ID# 206336 San Juan, , Puerto Rico, 00921-3201
    • Puerto Rico Hematology Oncolog /ID# 206337 San Juan, , Puerto Rico, 00959
  • Romania, Dolj
    • S.C. Centrul de Oncologie Sf. Nectarie S.R.L. /ID# 227623 Craiova, Dolj, Romania, 200347
  • Romania,
    • Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti /ID# 227216 Bucharest, , Romania, 022328
    • Coltea Clinical Hospital /ID# 227241 Bucharest, , Romania, 030171
    • S.C. Gral Medical Srl /Id# 227215 Bucharest, , Romania, 031422
    • Institutul Oncologic /ID# 206320 Cluj Napoca, , Romania, 400015
    • Spitalul Municipal Ploiesti /ID# 229097 Ploiesti, , Romania, 100337
    • Oncomed SRL /ID# 205616 Timisoara, , Romania, 300239
  • Russian Federation, Novosibirskaya Oblast
    • Avicenna medical center /ID# 212397 Novosibirsk, Novosibirskaya Oblast, Russian Federation, 630099
  • Russian Federation, Tatarstan, Respublika
    • Tatarstan Cancer Center /ID# 206463 Kazan, Tatarstan, Respublika, Russian Federation, 420029
  • Russian Federation, Volgogradskaya Oblast
    • Volgograd Regional Clinical Oncology Dispensary /ID# 206520 Volgograd, Volgogradskaya Oblast, Russian Federation, 400138
  • Russian Federation,
    • Arkhangelsk Clinical Oncology Dispensary /ID# 216418 Arkhangelsk, , Russian Federation, 163045
    • LLC Evimed /ID# 216473 Chelyabinsk, , Russian Federation, 454048
    • Kostroma region oncology center /ID# 231317 Kostroma, , Russian Federation, 156005
    • Univercity Headache Clynic,LTD /ID# 212080 Moscow, , Russian Federation, 109028
    • Hadassah Medical Moscow /ID# 232066 Moscow, , Russian Federation, 121205
    • VitaMed LLC /ID# 228957 Moscow, , Russian Federation, 121309
    • Medical Radiological Res Ctr /ID# 231263 Obninsk, , Russian Federation, 249036
    • PMI Euromedservice /ID# 206390 Pushkin, , Russian Federation, 196603
    • LLC Novaya Clinica /ID# 216262 Pyatigorsk, , Russian Federation, 357502
    • St.Petersburg City Cancer Center /ID# 206405 Sankt-Peterburg, , Russian Federation, 198218
    • Center of Palliative Medicine De Vita /ID# 212900 St. Petersburg, , Russian Federation, 197343
  • Spain, A Coruna
    • Hospital Clínico Universitario de Santiago-CHUS /ID# 204367 Santiago de Compostela, A Coruna, Spain, 15706
  • Spain, Barcelona
    • Instituto Catalan de Oncologia (ICO) Badalona /ID# 216106 Badalona, Barcelona, Spain, 08916
  • Spain, Malaga
    • Hospital Regional de Malaga /ID# 216081 Málaga, Malaga, Spain, 29010
  • Spain,
    • Hospital Universitario Vall d'Hebron /ID# 206997 Barcelona, , Spain, 08035
    • Hospital Universitario Ramon y Cajal /ID# 203922 Madrid, , Spain, 28034
    • Hospital Universitario HM Sanchinarro /ID# 203913 Madrid, , Spain, 28050
    • Hospital Universitario Virgen del Rocio /ID# 216058 Sevilla, , Spain, 41013
    • Hospital Universitario y Politecnico La Fe /ID# 203862 Valencia, , Spain, 46026
  • Switzerland, Zuerich
    • Kantonsspital Winterthur /ID# 231284 Winterthur, Zuerich, Switzerland, 8400
  • Switzerland,
    • Universitaetsspital Basel /ID# 230977 Basel, , Switzerland, 4031
  • Taiwan, Tainan
    • National Cheng Kung University Hospital /ID# 205307 Tainan City, Tainan, Taiwan, 70403
  • Taiwan, Taipei
    • National Taiwan University Hospital /ID# 205100 Taipei City, Taipei, Taiwan, 100
  • Taiwan,
    • Dalin Tzu Chi General Hospital /ID# 205309 Dalin Township, , Taiwan, 622
    • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 205831 Kaohsiung, , Taiwan, 80708
    • Kaohsiung Chang Gung Memorial Hospital /ID# 205423 Kaohsiung, , Taiwan, 833
    • Taipei Med Univ Shuang Ho Hosp /ID# 215356 New Taipei City, , Taiwan, 23561
    • Taichung Veterans General Hosp /ID# 205308 Taichung City, , Taiwan, 40705
    • Koo Foundation Sun Yat-Sen Cancer Center /ID# 227336 Taipei, , Taiwan, 112
    • Linkou Chang Gung Memorial Ho /ID# 205424 Taoyuan City, , Taiwan, 33305
  • Turkey,
    • Adana Sehir Egitim ve Arastirma Hastanesi /ID# 206000 Adana, , Turkey, 01060
    • Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi /ID# 205243 Ankara, , Turkey, 06200
    • Akdeniz Universitesi Tip Fakul /ID# 205238 Antalya, , Turkey, 07059
    • Trakya University Medical Facu /ID# 205242 Edirne, Istanbul, , Turkey, 22030
    • Prof. Dr. Suleyman Yalcin Sehir Hastanesi /ID# 215082 Istanbul, , Turkey, 34722
    • Dr. Suat Seren Gogus Has /ID# 215083 Izmir, , Turkey, 35110
  • United Kingdom,
    • Heart of England NHS Foundation Trust /ID# 206209 Birmingham, , United Kingdom, B9 5SS
    • Nottingham Univ Hospitals NHS /ID# 231224 Nottingham, , United Kingdom, NG5 1PB
    • Oxford Univ Hosp NHS Trust /ID# 205890 Oxford, , United Kingdom, OX3 7LE

Sponsors and Collaborators

AbbVie

More Information

No publications provided

Responsible Party: Sponsor
ClinicalTrials.gov Identifier: NCT03539536
Other Study ID Numbers: 2018-001772-38
Study First Received:
Last Updated:
Health Authority:

Keywords provided by AbbVie:

Non-small Cell Lung Cancer (NSCLC)

Cancer

Telisotuzumab vedotin

ABBV-399

c-Met, c-Met overexpression

metastatic

MET gene amplification

Additional relevant MeSH terms:

Lung Neoplasms

Carcinoma, Non-Small-Cell Lung

Next Steps


If you are interested in this protocol or in other treatment options at Massachusetts General Hospital, please Request a Consultation.







ClinicalTrials.gov processed this data on June 10, 2021