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Diseases, Genes & Mutations
Diseases
Bladder Cancer
ATM
all mutations
ATR
no-mutation in ATR
Beta-Catenin (CTNNB1)
all mutations
BRCA1 and BRCA2
Inherited Germline Mutations
Sporadic Somatic Mutations
ERBB2 (HER2)
Gene Amplification
Overexpression
FGFR 1, 2, 3 and 4
All Genetic Alterations
HRAS
Activating Mutations
IDH1
PIK3CA
activating mutations
PTEN
Loss of Function
TP53
All Mutations
Brain Tumors
ATM
all mutations
ATR
no-mutation in ATR
NF2
all inactivating mutations
PTCH (Patched)
Inactivating Mutations
SMO (Smoothened)
P641A (pro641ala)
activating mutations
L412F (leu412phe)
S278I (ser278Ile)
S533N (Ser533Asn)
T534P (Thr534Pro)
W535L (trp535leu)
EGFR
Gene Amplification
FGFR 1, 2, 3 and 4
All Genetic Alterations
IDH1
R132C (c.394C>T)
R132G (c.394C>G)
R132H (c.395G>A)
R132L (c.395G>T)
R132S (c.394C>A)
IDH2
R140L (c.419G>T)
R140Q (c.419G>A)
R140W (c.418C>T)
R172G (c.514A>G)
R172K (c.515G>A)
R172M (c.515G>T)
R172W (c.514A>T)
MET
Gene Amplification
PIK3CA
E542K (c.1624G>A)
E542Q (c.1624G>C)
E545A (c.1634A>C)
E545G (c.1634A>G)
E545K (c.1633G>A)
E545Q (c.1633G>C)
E545V (c.1634A>T)
G1049R (c.3145G>C)
G1049S (c.3145G>A)
H1047L (c.3140A>T)
H1047R (c.3140A>G)
H1047Y (c.3139C>T)
Q546E (c.1636C>G)
Q546K (c.1636C>A)
Q546L (c.1637A>T)
Q546P (c.1637A>C)
Q546R (c.1637A>G)
R88Q (c.263G>A)
PTEN
K267fs*9 (c.799delA)
K267fs*9 (c.800delA)
R130G (c.388C>G)
R130X (c.388C>T)
R173C (c.517C>T)
R233X (c.697C>T)
TP53
All Mutations
TRK 1,2,3
alternative splicing
gene fusion
in-frame deletion
mutation
Breast Cancer
ATM
all mutations
ATR
no-mutation in ATR
BRAF
activating mutation
V600A (c.1799T>C)
V600E (c.1799T>A)
V600G (c.1799T>G)
V600K (c.1798_1799GT>AA)
V600M (c.1798G>A)
V600R (c.1798_1799GT>AG)
BRCA1 and BRCA2
Inherited Germline Mutations
Sporadic Somatic Mutations
ERBB2 (HER2)
Gene Amplification
ERBB3 (HER3)
amplification, overexpression, mutation
ESR1
Gene Amplification
Overexpression
FGFR 1, 2, 3 and 4
All Genetic Alterations
PIK3CA
activating mutations
E542K (c.1624G>A)
E542Q (c.1624G>C)
E545A (c.1634A>C)
E545G (c.1634A>G)
E545K (c.1633G>A)
E545Q (c.1633G>C)
E545V (c.1634A>T)
G1049R (c.3145G>C)
G1049S (c.3145G>A)
H1047L (c.3140A>T)
H1047R (c.3140A>G)
H1047Y (c.3139C>T)
Q546E (c.1636C>G)
Q546K (c.1636C>A)
Q546L (c.1637A>T)
Q546P (c.1637A>C)
Q546R (c.1637A>G)
R88Q (c.263G>A)
PTEN
Loss of Function
TP53
All Mutations
Colorectal Cancer
AKT1
Activating Mutations
E17K (c.49G>A)
ALK
Activating mutations
APC
mutation (insertion, deletion, mutation)
ATM
all mutations
ATR
no-mutation in ATR
FGFR 1, 2, 3 and 4
All Genetic Alterations
HDM2/MDM2
amplification
MET
Gene Amplification
ROS1
Gene Translocation
SMO (Smoothened)
activating mutations
BRAF
activating mutation
V600E (c.1799T>A)
Beta-Catenin (CTNNB1)
all mutations
EGFR
Activating Mutations
Gene Amplification
Exon 19 Deletion
Exon 20 Insertion
T790M (c.2369C>T)
ERBB2 (HER2)
Gene Amplification
KRAS
Activating Mutations
G12C (c.34G>T)
G13C (c.37G>T)
NRAS
Activating Mutations
G12C (c.34G>T)
G13C (c.37G>T)
PIK3CA
activating mutations
PTEN
Loss of Function
TP53
All Mutations
TRK 1,2,3
gene fusion
Endometrial Cancer
ATM
all mutations
ATR
no-mutation in ATR
BRAF
Beta-Catenin (CTNNB1)
all mutations
T41N (c.122C>A)
ERBB2 (HER2)
Gene Amplification
FGFR 1, 2, 3 and 4
All Genetic Alterations
PIK3CA
E542K (c.1624G>A)
E542Q (c.1624G>C)
E545A (c.1634A>C)
E545G (c.1634A>G)
E545K (c.1633G>A)
E545Q (c.1633G>C)
E545V (c.1634A>T)
G1049R (c.3145G>C)
G1049S (c.3145G>A)
H1047L (c.3140A>T)
H1047R (c.3140A>G)
H1047Y (c.3139C>T)
Q546E (c.1636C>G)
Q546K (c.1636C>A)
Q546L (c.1637A>T)
Q546P (c.1637A>C)
Q546R (c.1637A>G)
R88Q (c.263G>A)
PTEN
K267fs*9 (c.799delA)
K267fs*9 (c.800delA)
R130G (c.388C>G)
R130X (c.388C>T)
R173C (c.517C>T)
R233X (c.697C>T)
TP53
All Mutations
Gastric/Esophageal
APC
mutation (insertion, deletion, mutation)
ATM
all mutations
ATR
no-mutation in ATR
Beta-Catenin (CTNNB1)
all mutations
EGFR
Activating Mutations
ERBB2 (HER2)
Gene Amplification
FGFR 1, 2, 3 and 4
All Genetic Alterations
MET
Gene Amplification
TRK 1,2,3
gene fusion
Head & Neck Cancers
ATM
all mutations
ATR
no-mutation in ATR
BRAF
G466A (c.1397G>C)
G466E (c.1397G>A)
G466V (c.1397G>T)
G469A (c.1406G>C)
G469E (c.1406G>A)
G469V (c.1406G>T)
L597Q (c.1790T>A)
L597R (c.1790T>G)
L597S (c.1789_1790CT>TC)
L597V (c.1789C>G)
V600A (c.1799T>C)
V600E (c.1799T>A)
V600G (c.1799T>G)
V600K (c.1798_1799GT>AA)
V600M (c.1798G>A)
V600R (c.1798_1799GT>AG)
Beta-Catenin (CTNNB1)
EGFR
Activating Mutations
E746_A750del (c.2235_2249del15)
E746_A750del (c.2236_2250del15)
Exon 19 Deletion
Exon 20 Insertion
G719A (c.2156G>C)
G719C (c.2155G>T)
G719D (c.2156G>A)
G719S (c.2155G>A)
Gene Amplification
L858R (c.2573T>G)
L861Q (c.2582T>A)
L861R (c.2582T>G)
T790M (c.2369C>T)
ERBB2 (HER2)
Gene Amplification
FGFR 1, 2, 3 and 4
All Genetic Alterations
FGFR 1, 2, 3 and 4
PIK3CA
E542K (c.1624G>A)
E542Q (c.1624G>C)
E545A (c.1634A>C)
E545G (c.1634A>G)
E545K (c.1633G>A)
E545Q (c.1633G>C)
E545V (c.1634A>T)
G1049R (c.3145G>C)
G1049S (c.3145G>A)
H1047L (c.3140A>T)
H1047R (c.3140A>G)
H1047Y (c.3139C>T)
Q546E (c.1636C>G)
Q546K (c.1636C>A)
Q546L (c.1637A>T)
Q546P (c.1637A>C)
Q546R (c.1637A>G)
R88Q (c.263G>A)
TP53
All Mutations
Leukemias
ATM
all mutations
ATR
no-mutation in ATR
HRAS
G12A (c.35G>C)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183G>C)
Q61H (c.183G>T)
Q61K (c.181C>A)
Q61L (c.182_183AG>TA)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61Q (c.183G>A)
Q61R (c.182_183AG>GA)
Q61R (c.182_183AG>GT)
Q61R (c.182A>G)
IDH1
R132C (c.394C>T)
R132G (c.394C>G)
R132H (c.395G>A)
R132L (c.395G>T)
R132S (c.394C>A)
IDH2
R140L (c.419G>T)
R140Q (c.419G>A)
R140W (c.418C>T)
R172G (c.514A>G)
R172K (c.515G>A)
R172M (c.515G>T)
R172W (c.514A>T)
KRAS
A146P (c.436G>C)
A146T (c.436G>A)
A146V (c.437C>T)
G12A (c.35G>C)
G12C (c.34G>T)
G12D (c.35G>A)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13A (c.38G>C)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183A>C)
Q61H (c.183A>T)
Q61K (c.181C>A)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61R (c.182A>G)
NRAS
G12A (c.35G>C)
G12C (c.34G>T)
G12D (c.35G>A)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13A (c.38G>C)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183A>C)
Q61H (c.183A>T)
Q61K (c.181C>A)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61Q (c.183A>G)
Q61R (c.182A>G)
Lung Cancer
ALK
C1156Y
D1203N
D1203N+E1210K
D1203N+F1174C
E1210K
F1174C
G1202del
G1202R
G1269A
I1171N
I1171S
I1171T
L1196M
Gene Translocation
L1198F
ATM
all mutations
ATR
no-mutation in ATR
BRAF
activating mutation
V600E (c.1799T>A)
Beta-Catenin (CTNNB1)
all mutations
EGFR
Activating Mutations
L858R (c.2573T>G)
L861Q (c.2582T>A)
S768I
T790M (c.2369C>T)
ERBB2 (HER2)
All Genetic Alterations
Exon 20 Insertion
Gene Amplification
KRAS
Activating Mutations
G12C (c.34G>T)
G13C (c.37G>T)
MET
All Mutations
Exon 14 Skipping
Gene Amplification
NRAS
Activating Mutations
G12C (c.34G>T)
G13C (c.37G>T)
PIK3CA
activating mutations
PTEN
Loss of Function
RET
Gene Translocation
ROS1
Gene Translocation
TP53
All Mutations
TRK 1,2,3
gene fusion
Gall Bladder and Bile Duct Cancers
ATM
all mutations
ATR
no-mutation in ATR
FGFR 1, 2, 3 and 4
All Genetic Alterations
FGFR2
Gene Fusion
IDH1
all amino acid position R132 mutations
IDH2
all amino acid position R140 mutations
all amino acid position R172 mutations
Prostate Cancer
ATM
all mutations
ATR
no-mutation in ATR
BRAF
BRCA1 and BRCA2
Inherited Germline Mutations
Sporadic Somatic Mutations
FGFR 1, 2, 3 and 4
All Genetic Alterations
PTEN
K267fs*9 (c.799delA)
K267fs*9 (c.800delA)
R130G (c.388C>G)
R130X (c.388C>T)
R173C (c.517C>T)
R233X (c.697C>T)
TP53
All Mutations
Bone and Soft Tissue Sarcoma
ALK
Gene Translocation
ATM
all mutations
ATR
no-mutation in ATR
BRAF
G466A (c.1397G>C)
G466E (c.1397G>A)
G466V (c.1397G>T)
G469A (c.1406G>C)
G469E (c.1406G>A)
G469V (c.1406G>T)
L597Q (c.1790T>A)
L597R (c.1790T>G)
L597S (c.1789_1790CT>TC)
L597V (c.1789C>G)
V600A (c.1799T>C)
V600E (c.1799T>A)
V600G (c.1799T>G)
V600K (c.1798_1799GT>AA)
V600M (c.1798G>A)
V600R (c.1798_1799GT>AG)
Beta-Catenin (CTNNB1)
all mutations
FGFR 1, 2, 3 and 4
All Genetic Alterations
HDM2/MDM2
amplification
KIT
D816A (c.2447A>C)
D816G (c.2447A>G)
D816V (c.2447A>T)
PIK3CA
activating mutations
TP53
All Mutations
Melanoma
ATM
all mutations
ATR
no-mutation in ATR
BRAF
activating mutation
V600A (c.1799T>C)
V600E (c.1799T>A)
V600G (c.1799T>G)
V600K (c.1798_1799GT>AA)
V600M (c.1798G>A)
V600R (c.1798_1799GT>AG)
HDM2/MDM2
amplification
amplification (1)
KIT
Activation mutations in exon 11 and 13
Gene Amplification
MAP2K1 (MEK1)
D67N (c.199G>A)
K57N (c.171G>T)
Q56P (c.167A>C)
NRAS
G12A (c.35G>C)
G12C (c.34G>T)
G12D (c.35G>A)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13A (c.38G>C)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183A>C)
Q61H (c.183A>T)
Q61K (c.181C>A)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61R (c.182A>G)
PTEN
K267fs*9 (c.799delA)
K267fs*9 (c.800delA)
R130G (c.388C>G)
R130X (c.388C>T)
R173C (c.517C>T)
R233X (c.697C>T)
TP53
All Mutations
G245C (c.733G>T)
G245R (c.733G>C)
G245S (c.733G>A)
R175H (c.524G>A)
R175L (c.524G>T)
R248G (c.742C>G)
R248L (c.743G>T)
R248P (c.743G>C)
R248Q (c.743G>A)
R248W (c.742C>T)
R273C (c.817C>T)
R273G (c.817C>G)
R273H (c.818G>A)
R273L (c.818G>T)
R273P (c.818G>C)
R273S (c.817C>A)
R306X (c.916C>T)
Thyroid Tumors
ATM
all mutations
ATR
no-mutation in ATR
BRAF
G466A (c.1397G>C)
G466E (c.1397G>A)
G466V (c.1397G>T)
G469A (c.1406G>C)
G469E (c.1406G>A)
G469V (c.1406G>T)
L597Q (c.1790T>A)
L597R (c.1790T>G)
L597S (c.1789_1790CT>TC)
L597V (c.1789C>G)
V600A (c.1799T>C)
V600E (c.1799T>A)
V600G (c.1799T>G)
V600K (c.1798_1799GT>AA)
V600M (c.1798G>A)
V600R (c.1798_1799GT>AG)
HRAS
G12A (c.35G>C)
G12C (c.34G>T)
G12D (c.35G>A)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183G>C)
Q61H (c.183G>T)
Q61K (c.181C>A)
Q61L (c.182_183AG>TA)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61R (c.182_183AG>GA)
Q61R (c.182_183AG>GT)
Q61R (c.182A>G)
NRAS
G12A (c.35G>C)
G12C (c.34G>T)
G12D (c.35G>A)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13A (c.38G>C)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183A>C)
Q61H (c.183A>T)
Q61K (c.181C>A)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61R (c.182A>G)
PIK3CA
E542K (c.1624G>A)
E542Q (c.1624G>C)
E545A (c.1634A>C)
E545G (c.1634A>G)
E545K (c.1633G>A)
E545Q (c.1633G>C)
E545V (c.1634A>T)
G1049R (c.3145G>C)
G1049S (c.3145G>A)
H1047L (c.3140A>T)
H1047R (c.3140A>G)
H1047Y (c.3139C>T)
Q546E (c.1636C>G)
Q546K (c.1636C>A)
Q546L (c.1637A>T)
Q546P (c.1637A>C)
Q546R (c.1637A>G)
RET
Gene Translocation
M918T (c.2753T>C )
TP53
All Mutations
Genes
AKT1
Activating Mutations
E17K (c.49G>A)
ALK
Activating mutations
C1156Y
D1203N
D1203N+E1210K
D1203N+F1174C
E1210K
F1174C
G1202del
G1202R
G1269A
I1171N
I1171S
I1171T
L1196M
Gene Translocation
L1198F
ATM
all mutations
ATR
no-mutation in ATR
BRCA1 and BRCA2
Inherited Germline Mutations
Sporadic Somatic Mutations
DNA-PKcs
All Mutations
NF2
all inactivating mutations
PTCH (Patched)
Inactivating Mutations
SMO (Smoothened)
activating mutations
L412F (leu412phe)
P641A (pro641ala)
S278I (ser278Ile)
S533N (Ser533Asn)
T534P (Thr534Pro)
W535L (trp535leu)
BRAF
activating mutation
V600A (c.1799T>C)
V600E (c.1799T>A)
V600G (c.1799T>G)
V600K (c.1798_1799GT>AA)
V600M (c.1798G>A)
V600R (c.1798_1799GT>AG)
Beta-Catenin (CTNNB1)
all mutations
EGFR
Activating Mutations
E746_A750del (c.2235_2249del15)
E746_A750del (c.2236_2250del15)
Gene Amplification
Exon 19 Deletion
Exon 20 Insertion
G719A (c.2156G>C)
G719C (c.2155G>T)
G719D (c.2156G>A)
G719S (c.2155G>A)
L858R (c.2573T>G)
L861Q (c.2582T>A)
L861R (c.2582T>G)
S768I
T790M (c.2369C>T)
ERBB2 (HER2)
All Genetic Alterations
Gene Amplification
Overexpression
ERBB3 (HER3)
amplification, overexpression, mutation
HDM2/MDM2
amplification
ESR1
Gene Amplification
Activating Mutations
Overexpression
FGFR 1, 2, 3 and 4
All Genetic Alterations
HRAS
Activating Mutations
G12A (c.35G>C)
G12C (c.34G>T)
G12D (c.35G>A)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183G>C)
Q61H (c.183G>T)
Q61K (c.181C>A)
Q61L (c.182_183AG>TA)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61R (c.182_183AG>GA)
Q61R (c.182_183AG>GT)
Q61R (c.182A>G)
IDH1
all amino acid position R132 mutations
IDH2
all amino acid position R140 mutations
all amino acid position R172 mutations
KIT
Activation mutations in exon 11 and 13
Gene Amplification
D816A (c.2447A>C)
D816G (c.2447A>G)
D816V (c.2447A>T)
KRAS
A146P (c.436G>C)
A146T (c.436G>A)
A146V (c.437C>T)
Activating Mutations
G12A (c.35G>C)
G12C (c.34G>T)
G12D (c.35G>A)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13A (c.38G>C)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183A>C)
Q61H (c.183A>T)
Q61K (c.181C>A)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61R (c.182A>G)
Q61X (c.181C>T)
MAP2K1 (MEK1)
D67N (c.199G>A)
K57N (c.171G>T)
MAP2K1 (MEK) -
Q56P (c.167A>C)
MET
All Mutations
Exon 14 Skipping
Gene Amplification
NOTCH1
NRAS
Activating Mutations
G12A (c.35G>C)
G12C (c.34G>T)
G12D (c.35G>A)
G12R (c.34G>C)
G12S (c.34G>A)
G12V (c.35G>T)
G13A (c.38G>C)
G13C (c.37G>T)
G13D (c.38G>A)
G13R (c.37G>C)
G13S (c.37G>A)
G13V (c.38G>T)
Q61E (c.181C>G)
Q61H (c.183A>C)
Q61H (c.183A>T)
Q61K (c.181C>A)
Q61L (c.182A>T)
Q61P (c.182A>C)
Q61R (c.182A>G)
PIK3CA
activating mutations
E542K (c.1624G>A)
E542Q (c.1624G>C)
E545A (c.1634A>C)
E545G (c.1634A>G)
E545K (c.1633G>A)
E545Q (c.1633G>C)
E545V (c.1634A>T)
G1049R (c.3145G>C)
G1049S (c.3145G>A)
H1047L (c.3140A>T)
H1047R (c.3140A>G)
H1047Y (c.3139C>T)
Q546E (c.1636C>G)
Q546K (c.1636C>A)
Q546L (c.1637A>T)
Q546P (c.1637A>C)
Q546R (c.1637A>G)
R88Q (c.263G>A)
PTEN
Loss of Function
RET
Gene Translocation
M918T (c.2753T>C )
ROS1
Gene Translocation
TP53
All Mutations
wild type
APC
loss of gene
loss of heterozygosity (LOH)
mutation (insertion, deletion, mutation)
TRK 1,2,3
gene fusion
Drugs
ABT-414
AG-120
AG-221
AMG 479
AMG 706
AMG102
AP24534
AP26113
ARN-810
ARQ 197
ARRY-334543
AUY922
AV-203
AV-299
AV-951
AZD0530
AZD4547
AZD6244
BAY 73-4506
BEZ235
BGJ398
BGT226
BIBF 1120
BIBW 2992
BKM120
BLU-554
BMS-582664
BMS-690514
BVD-523
BYL719
CEP32496
CH5424802
CO-1686
DCC-2701
Debio 1347
E7050
E7080
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GDC-0032
GDC-0068
GDC-0941
GDC-0973
GDC-0980
Gleevec
GSK1120212
GSK1363089
GSK2118436
Herceptin
HKI-272
INK1117
INK128
Inlyta
JNJ 54179060
KRX-0401
LDE225
LDK378
LEE011
LGX818
LJM716
LOXO-101
MEDI4736
MEDI-575
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MEK162
MGCD516
MK-1775
MK-8669
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MM-121
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MSC1936369B
MSC2363318A
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PF-00299804
PF-04691502
PF-05212384
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RAF265
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XL147
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Resources
Recent Advances
Osimertinib receives approval for treatment of metastatic NSCLC
Afatinib receives broadened approval for NSCLC
Alectinib approved for ALK positive NSCLC
Dabrafenib and Trametinib Gets Accelerated Approval by FDA for NSCLC treatment
Lartruvo Gets Accelerated Approval by FDA for Sarcoma treatment
Reversal of Crizotinib Resistance
FDA approves crizotinib (Xalkori) for certain NSCLC patients
Exciting Ceritinib study results for ALK-rearranged non-small cell lung cancer (NSCLC) patients who
Breakthrough Therapy Designation Granted to BI 1482694 for the Treatment of Patients with EGFR-mutat
U.S. Food and Drug Administration (FDA) grants accelerated approval to Alecensa (alectinib)
U.S. Food and Drug Administration grants accelerated approval to Osimertinib for Non-Small Cell Lung
U.S. Food and Drug Administration (FDA) approved Iressa (gefitinib)
Crizotinib treatment effective against ROS1-positive lung cancer
U. S. Food and Drug Administration granted accelerated approval to ceritinib
Mutated IDH1 identifies brain tumors that benefit from aggressive surgery
Multi-institutional team finds targetable BRAF mutations in rare brain tumor
U. S. Food and Drug Administration granted accelerated approval to trametinib and dabrafenib
U. S. Food and Drug Administration approved afatinib
MGH-led crizotinib studies shed new light on targeted lung cancer therapy
U. S. Food and Drug Administration approved dabrafenib
U. S. Food and Drug Administration approved trametinib
U. S. Food and Drug Administration approved erlotinib
Next-generation PI3 Kinase Inhibitor Demonstrated Early Efficacy, Safety
U. S. Food and Drug Administration approved regorafenib
BRAF inhibitor treatment causes melanoma cells to shift how they produce energy
Transition in cell type parallels treatment response, disease progression in breast cancer
MGH-led study of dabrafenib and trametinib named among Clinical Research Forum's Top 10 Clinical Res
Cancer Center team identifies potential treatment target for KRAS
Combination of targeted drugs delays resistance in melanoma patients
Mass. General study defines a new genetic subtype of lung cancer
Novel gene mutations associated with bile duct cancer
The path to personalized treatment
New lung cancer pill highlights improved way of treating patients
First credible treatment option for metastatic melanoma
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Our Team
Abbott, Gerald, MD
Ackman, Jeanne, MD
Al-Samkari, Hanny, MD
Arellano, Ronald, MD
Arrillaga-Romany, Isabel, MD, PhD
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Blake, Michael, MD
Boal, Lauren, MD
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Kim, Michelle, MD, PhD
Klempner, Samuel, MD
Knowlton, Sasha, MD
Lin, Jessica, MD
Malcolm, Alys, MD
Maus, Marcela, MD, PhD
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Miller, Adam, MD
Miller, David, MD, PhD
Miller, Julie, MD, PhD
Mooradian, Meghan, MD
Nai, Qiang, MD
Narayan, Rupa, MD
Narayanasami, Uma, MBBS
Newhouse, Amy, MD
Newman, Erik, MD
Nguyen, Anvy, MD
O'Donnell, Elizabeth, MD
Ott, Harald, MD
Parsons, Michael, PhD
Patel, Chirayu, MD, MPH
Perez-Lougee, Giselle, PhD
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