HDM2/MDM2

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Expand Collapse HDM2/MDM2  - General Description HDM2, the human version of mouse MDM2 is a protein that negatively regulates the TP53 tumor suppressor protein. HDM2/MDM2 is one of a family of proteins in the ubiquitin proteolytic pathway that regulate proteins by targeting them for degradation. HDM2/MDM2 binds to and inactivates TP53, which is a tumor suppressor that causes growth arrest when cells suffer trauma or DNA damage. Growth arrest allows cells to repair their DNA prior to resuming growth. In some cancers, HDM2/MDM2 is genetically altered, causing production of more HDM2/MDM2 than is normally in cells. This abundance of HDM2/MDM2 binds to TP53, inducing its degradation, and without TP53, the cell cannot stop growing to repair damaged DNA before continuing to divide. Cell division that continues despite damaged DNA is more likely to lead to cancer. Source: HDM2, the human version of mouse MDM2 is a protein that negatively regulates the TP53 tumor suppressor protein. HDM2/MDM2 is one of a family of proteins in the ubiquitin proteolytic pathway that regulate proteins by targeting them for degradation. HDM2/MDM2 binds to and inactivates TP53, which is a tumor suppressor that causes growth arrest when cells suffer trauma or DNA damage. Growth arrest allows cells to repair their DNA prior to resuming growth. In some cancers, HDM2/MDM2 is genetically altered, causing production of more HDM2/MDM2 than is normally in cells. This abundance of HDM2/MDM2 binds to TP53, inducing its degradation, and without TP53, the cell cannot stop growing to repair damaged DNA before continuing to divide. Cell division that continues despite damaged DNA is more likely to lead to cancer. Source: http://targetedcancercare.massgeneral.org/My-Trial-Guide/Genes/HDM2-MDM2.aspx Gene Accordion Expanded

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HDM2, the human version of mouse MDM2 is a protein that negatively regulates the TP53 tumor suppressor protein. HDM2/MDM2 is one of a family of proteins in the ubiquitin proteolytic pathway that regulate proteins by targeting them for degradation. HDM2/MDM2 binds to and inactivates TP53, which is a tumor suppressor that causes growth arrest when cells suffer trauma or DNA damage. Growth arrest allows cells to repair their DNA prior to resuming growth. In some cancers, HDM2/MDM2 is genetically altered, causing production of more HDM2/MDM2 than is normally in cells. This abundance of HDM2/MDM2 binds to TP53, inducing its degradation, and without TP53, the cell cannot stop growing to repair damaged DNA before continuing to divide. Cell division that continues despite damaged DNA is more likely to lead to cancer.

Source:

HDM2, the human version of mouse MDM2 is a protein that negatively regulates the TP53 tumor suppressor protein. HDM2/MDM2 is one of a family of proteins in the ubiquitin proteolytic pathway that regulate proteins by targeting them for degradation. HDM2/MDM2 binds to and inactivates TP53, which is a tumor suppressor that causes growth arrest when cells suffer trauma or DNA damage. Growth arrest allows cells to repair their DNA prior to resuming growth. In some cancers, HDM2/MDM2 is genetically altered, causing production of more HDM2/MDM2 than is normally in cells. This abundance of HDM2/MDM2 binds to TP53, inducing its degradation, and without TP53, the cell cannot stop growing to repair damaged DNA before continuing to divide. Cell division that continues despite damaged DNA is more likely to lead to cancer.

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