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Torisel

       
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Expand Collapse Torisel  - General Description An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.
Chemical Name
42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin
Drug Code Name
CCI-779
Synonyms
cell cycle inhibitor 779; rapamycin analog CCI-779
US Brand Names
Torisel
An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.
Chemical Name
42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin
Drug Code Name
CCI-779
Synonyms
cell cycle inhibitor 779; rapamycin analog CCI-779
US Brand Names
Torisel

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