Experimental:Gallium PET/MR Imaging
Siemens PET/MR scanner at Martinos Center for Biomedical Imaging will be use.
Standard Siemens software will be used to perform image analysis and measure parameters such as SUVmean, SUVmax and MTV.
Standard LAR Octreotide will be administered.
Ga-68-DOTA-TOC that will be administered prior to PET/MR imaging at 7 days after standard LAR octreotide administration and again at 28 day.
Ga-68-DOTA-TOC will be administered as a single intravenous dose at a pre-determine dosage.
LAR octreotide is a man-made protein that is similar to a hormone in the body called somatostatin. LAR Octreotide lowers many substances in the body such as insulin and glucagon, growth hormone, and chemicals that affect digestion. LAR octreotide is used to treat a variety of clinical conditions but most importantly to reduce flushing episodes and watery diarrhea caused by cancerous tumors such as neuroendocrine tumors.