Experimental:Abemaciclib with Surgery
Abemaciclib will be administered on a continuous twice daily dosing schedule
Patients who require re-operation will receive a short preoperative course of Abemaciclib
Tissue will be used to investigate the ability of Abemaciclib to pass through the blood brain barrier.
After recovery from surgery, participants will resume Abemaciclib. Each cycle lasts 28 days.