Clinical Trial - NCT02595424

Cisplatin, Carboplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients With Neuroendocrine Carcinoma of the Gastrointestinal Tract or Pancreas That Is Metastatic or Cannot Be Removed by Surgery

Recruiting

Sponsor: ECOG-ACRIN Cancer Research Group

Collaborators: National Cancer Institute (NCI)

Information provided by (Responsible party): Sponsor

ClinicalTrials.gov Identifier: NCT02595424

Protocol Info

Short Description: ECOG-ACRIN EA2142 COMPARATIVE THERAPIES IN GEP-NEC
Long Description: Randomized Phase II Study of Cisplatin and Etoposide versus Temozolomide and Capecitabine in Patients with Advanced G3 Non-Small Cell Gastroenteropancreatic Neuroendocrine Carcinomas
MGH Status: Open
Sponsor: Coop/ECOG
Disease Program: GI

Next Steps


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Purpose

This randomized phase II trial studies how well temozolomide and capecitabine work compared to standard treatment with cisplatin or carboplatin and etoposide in treating patients with neuroendocrine carcinoma of the gastrointestinal tract or pancreas that has spread to other parts of the body (metastatic) or cannot be removed by surgery. Drugs used in chemotherapy, such as temozolomide, capecitabine, cisplatin, carboplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Certain types of neuroendocrine carcinomas may respond better to treatments other than the current standard treatment of cisplatin and etoposide. It is not yet known whether temozolomide and capecitabine may work better than cisplatin or carboplatin and etoposide in treating patients with this type of neuroendocrine carcinoma, called non-small cell neuroendocrine carcinoma.
Condition Title Intervention Phase
Gastric Neuroendocrine Carcinoma Intestinal Neuroendocrine Carcinoma Pancreatic Neuroendocrine Carcinoma Capecitabine Carboplatin Cisplatin Etoposide Laboratory Biomarker Analysis Temozolomide Phase 2
Study Type Interventional
Official Title Randomized Phase II Study of Cisplatin and Etoposide Versus Temozolomide and Capecitabine in Patients With Advanced G3 Non-small Cell Gastroenteropancreatic Neuroendocrine Carcinomas

Primary Outcome Measures

PFS [Time Frame: Time from randomization to documented progression or death without progression, assessed up to 1 year] [Designated as safety issue: ]


Secondary Outcome Measures

Incidence of toxicity, graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 [Time Frame: Up to 30 days after last dose of protocol therapy] [Designated as safety issue: ]

OS [Time Frame: Time from randomization to death from any cause, assessed up to 5 years] [Designated as safety issue: ]

Response rate (complete response or partial response) by RECIST 1.1 [Time Frame: Up to 5 years] [Designated as safety issue: ]

Estimated Enrollment: 126
Study Start Date: November 2015
Estimated Study Completion Date: January 2029
Estimated Primary Completion Date: January 2024
Arms Assigned Interventions

Experimental:Arm A (capecitabine, temozolomide)

Patients receive capecitabine PO BID on days 1-14 and temozolomide PO QD on days 10-14. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Drug:Temozolomide
Given PO

Active Comparator:Arm B (cisplatin, carboplatin, etoposide)

Patients receive cisplatin IV on days 1-3 or carboplatin IV on day 1. Patients also receive etoposide IV on days 1-3. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug:Etoposide
Given IV

Eligibility

Ages Eligible for Study: N/A-N/A

Genders Eligible for Study: All

Accepts Healthly Volunteers: No

Inclusion Criteria:

  • Patients must have a locally advanced and unresectable or metastatic gastroenteropancreatic neuroendocrine carcinoma that is either known or suspected to be of gastrointestinal (GI) origin; primary tumors arising from the lung, gynecologic organs or prostate are not permitted
  • Patients must have pathologically/histologically confirmed tumor of non-small cell histology
  • Patients must have a Ki-67 proliferative index of 20-100% OR at least 10 mitotic figures per 10 high powered fields
  • Patients must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease must be obtained within 4 weeks prior to randomization and must be acquired by multiphasic computed tomography (CT) or contrast magnetic resonance imaging (MRI)
  • NOTE: positron emission tomography (PET)-CT scans are allowed provided the CT portion of the exam is equivalent to a diagnostic CT scan and includes both oral and IV contrast
  • Patients may not have had any prior systemic treatment for this malignancy (for example chemotherapy or somatostatin analogues); prior palliative radiation is permitted but radiated lesions may not be used for measurement
  • Patients may not have received any of the protocol agents within 5 years prior to randomization
  • Any prior surgeries must have been completed at least 4 weeks prior to randomization
  • Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
  • Patients may not be receiving any other investigational agents while on study treatment
  • Patients may not be receiving Coumadin while on treatment; other anticoagulants are allowed
  • Leukocytes >= 3,000/mm^3
  • Absolute neutrophil count >= 1,500/mm^3
  • Hemoglobin >= 9 g/dL
  • Platelets >= 100,000/mm^3
  • Total bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 X institutional ULN (if the patient has liver metastases)
  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 X institutional ULN or (=< 5 X institutional ULN if the patient has liver metastases)
  • Serum creatinine =< 1.5 X institutional ULN and creatinine clearance >= 60 ml/min
  • NOTE: creatinine clearance must be calculated using the Cockcroft-Gault equation
  • Patients must have a life expectancy of >= 12 weeks as determined clinically by the treating physician
  • Patients with brain metastases (either remote or current) or presence of carcinomatous meningitis are not eligible
  • Patients with known dihydropyrimidine dehydrogenase (DPD) deficiency will be excluded
  • Patients must NOT have active or uncontrolled infection, symptomatic heart failure, unstable angina pectoris, cardiac arrhythmia or a serious psychiatric illness/social situation that would limit compliance with study requirements
  • Patients with impaired decision making capacity may participate in the study if a legal authorized representative is available to consent
  • Patients must NOT have a history of allergic reactions attributed to compounds of similar chemical or biochemical composition to cisplatin, carboplatin, etoposide, temozolomide or capecitabine
  • Patients must NOT have absorption issues that would limit the ability to absorb study agents
  • Patients with a history of the following within =< 12 months of study entry are not eligible:
  • Arterial thromboembolic events
  • Unstable angina
  • Myocardial Infarction
  • Patients with symptomatic peripheral vascular disease are not eligible
  • Patients must NOT have previous or concurrent malignancy; exceptions are made for patients who meet any of the following conditions:
  • Non-melanoma skin cancer, in situ cervical cancer, superficial bladder cancer, or breast cancer in situ OR
  • Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR
  • Prior malignancy cured by non-surgical modalities and patient has been continuously disease free for > 5 years
  • Women must not be pregnant or breast-feeding
  • All females of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy
  • A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study
  • Patients must be able to swallow pills
  • Patients must be able to tolerate CT or magnetic resonance (MR) imaging including contrast agents as required for the treatment and the protocol
  • Patients who are known to have human immunodeficiency virus (HIV) or are on combination antiretroviral therapy are ineligible

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT02595424

Locations

  • United States, Arizona
    • Kingman Regional Medical Center Kingman, Arizona, United States, 86401
  • United States, Arkansas
    • Mercy Hospital Fort Smith Fort Smith, Arkansas, United States, 72903
    • CHI Saint Vincent Cancer Center Hot Springs Hot Springs, Arkansas, United States, 71913
  • United States, California
    • Kaiser Permanente-Deer Valley Medical Center Antioch, California, United States, 94531
    • PCR Oncology Arroyo Grande, California, United States, 93420
    • Sutter Auburn Faith Hospital Auburn, California, United States, 95602
    • Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn, California, United States, 95603
    • Alta Bates Summit Medical Center-Herrick Campus Berkeley, California, United States, 94704
    • Mills-Peninsula Medical Center Burlingame, California, United States, 94010
    • Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park, California, United States, 95682
    • Eden Hospital Medical Center Castro Valley, California, United States, 94546
    • Sutter Davis Hospital Davis, California, United States, 95616
    • Kaiser Permanente Dublin Dublin, California, United States, 94568
    • Kaiser Permanente-Fremont Fremont, California, United States, 94538
    • Palo Alto Medical Foundation-Fremont Fremont, California, United States, 94538
    • Kaiser Permanente-Fresno Fresno, California, United States, 93720
    • Los Angeles County-USC Medical Center Los Angeles, California, United States, 90033
    • USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033
    • Cedars Sinai Medical Center Los Angeles, California, United States, 90048
    • Memorial Medical Center Modesto, California, United States, 95355
    • Kaiser Permanente-Modesto Modesto, California, United States, 95356
    • Palo Alto Medical Foundation-Camino Division Mountain View, California, United States, 94040
    • Palo Alto Medical Foundation-Gynecologic Oncology Mountain View, California, United States, 94040
    • USC Norris Oncology/Hematology-Newport Beach Newport Beach, California, United States, 92663
    • Sutter Cancer Research Consortium Novato, California, United States, 94945
    • Kaiser Permanente-Oakland Oakland, California, United States, 94611
    • Palo Alto Medical Foundation Health Care Palo Alto, California, United States, 94301
    • Stanford Cancer Institute Palo Alto Palo Alto, California, United States, 94304
    • Keck Medical Center of USC Pasadena Pasadena, California, United States, 91105
    • Eisenhower Medical Center Rancho Mirage, California, United States, 92270
    • Kaiser Permanente-Redwood City Redwood City, California, United States, 94063
    • Kaiser Permanente-Richmond Richmond, California, United States, 94801
    • Kaiser Permanente-Roseville Roseville, California, United States, 95661
    • Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville, California, United States, 95661
    • Sutter Roseville Medical Center Roseville, California, United States, 95661
    • Kaiser Permanente Downtown Commons Sacramento, California, United States, 95814
    • Sutter Medical Center Sacramento Sacramento, California, United States, 95816
    • Kaiser Permanente-South Sacramento Sacramento, California, United States, 95823
    • Kaiser Permanente - Sacramento Sacramento, California, United States, 95825
    • California Pacific Medical Center-Pacific Campus San Francisco, California, United States, 94115
    • Kaiser Permanente-San Francisco San Francisco, California, United States, 94115
    • UCSF Medical Center-Mission Bay San Francisco, California, United States, 94158
    • Kaiser Permanente-Santa Teresa-San Jose San Jose, California, United States, 95119
    • Kaiser Permanente San Leandro San Leandro, California, United States, 94577
    • Kaiser Permanente-San Rafael San Rafael, California, United States, 94903
    • Kaiser San Rafael-Gallinas San Rafael, California, United States, 94903
    • Kaiser Permanente Medical Center - Santa Clara Santa Clara, California, United States, 95051
    • Palo Alto Medical Foundation-Santa Cruz Santa Cruz, California, United States, 95065
    • Kaiser Permanente-Santa Rosa Santa Rosa, California, United States, 95403
    • Sutter Pacific Medical Foundation Santa Rosa, California, United States, 95403
    • Kaiser Permanente-South San Francisco South San Francisco, California, United States, 94080
    • Kaiser Permanente-Stockton Stockton, California, United States, 95210
    • Palo Alto Medical Foundation-Sunnyvale Sunnyvale, California, United States, 94086
    • Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville, California, United States, 95687
    • Kaiser Permanente Medical Center-Vacaville Vacaville, California, United States, 95688
    • Kaiser Permanente-Vallejo Vallejo, California, United States, 94589
    • Sutter Solano Medical Center/Cancer Center Vallejo, California, United States, 94589
    • Kaiser Permanente-Walnut Creek Walnut Creek, California, United States, 94596
  • United States, Colorado
    • University of Colorado Hospital Aurora, Colorado, United States, 80045
    • Penrose-Saint Francis Healthcare Colorado Springs, Colorado, United States, 80907
    • Rocky Mountain Cancer Centers-Penrose Colorado Springs, Colorado, United States, 80907
    • Porter Adventist Hospital Denver, Colorado, United States, 80210
    • Mercy Medical Center Durango, Colorado, United States, 81301
    • Southwest Oncology PC Durango, Colorado, United States, 81301
    • Mountain Blue Cancer Care Center Golden, Colorado, United States, 80401
    • Rocky Mountain Cancer Centers-Lakewood Lakewood, Colorado, United States, 80228
    • Saint Anthony Hospital Lakewood, Colorado, United States, 80228
    • Littleton Adventist Hospital Littleton, Colorado, United States, 80122
    • Longmont United Hospital Longmont, Colorado, United States, 80501
    • Rocky Mountain Cancer Centers-Longmont Longmont, Colorado, United States, 80501
    • Parker Adventist Hospital Parker, Colorado, United States, 80138
    • Rocky Mountain Cancer Centers-Parker Parker, Colorado, United States, 80138
    • Saint Mary Corwin Medical Center Pueblo, Colorado, United States, 81004
    • Rocky Mountain Cancer Centers - Pueblo Pueblo, Colorado, United States, 81008
    • Rocky Mountain Cancer Centers-Thornton Thornton, Colorado, United States, 80260
  • United States, Delaware
    • Beebe Medical Center Lewes, Delaware, United States, 19958
    • Christiana Gynecologic Oncology LLC Newark, Delaware, United States, 19713
    • Delaware Clinical and Laboratory Physicians PA Newark, Delaware, United States, 19713
    • Helen F Graham Cancer Center Newark, Delaware, United States, 19713
    • Medical Oncology Hematology Consultants PA Newark, Delaware, United States, 19713
    • Christiana Care Health System-Christiana Hospital Newark, Delaware, United States, 19718
    • Beebe Health Campus Rehoboth Beach, Delaware, United States, 19971
    • Nanticoke Memorial Hospital Seaford, Delaware, United States, 19973
    • Christiana Care Health System-Wilmington Hospital Wilmington, Delaware, United States, 19801
  • United States, District of Columbia
    • MedStar Washington Hospital Center Washington, District of Columbia, United States, 20010
    • Sibley Memorial Hospital Washington, District of Columbia, United States, 20016
  • United States, Florida
    • Holy Cross Hospital Fort Lauderdale, Florida, United States, 33308
  • United States, Georgia
    • Grady Health System Atlanta, Georgia, United States, 30303
    • Emory University Hospital Midtown Atlanta, Georgia, United States, 30308
    • Emory University Hospital/Winship Cancer Institute Atlanta, Georgia, United States, 30322
    • Emory Saint Joseph's Hospital Atlanta, Georgia, United States, 30342
    • Emory Johns Creek Hospital Johns Creek, Georgia, United States, 30097
    • Medical Center of Central Georgia Macon, Georgia, United States, 31201
  • United States, Hawaii
    • Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii, United States, 96819
  • United States, Idaho
    • Saint Alphonsus Cancer Care Center-Boise Boise, Idaho, United States, 83706
    • Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho, United States, 83605
    • Kootenai Medical Center Coeur d'Alene, Idaho, United States, 83814
    • Walter Knox Memorial Hospital Emmett, Idaho, United States, 83617
    • Idaho Urologic Institute-Meridian Meridian, Idaho, United States, 83642
    • Saint Alphonsus Medical Center-Nampa Nampa, Idaho, United States, 83686
    • Kootenai Cancer Center Post Falls, Idaho, United States, 83854
    • Kootenai Cancer Clinic Sandpoint, Idaho, United States, 83864
  • United States, Illinois
    • Rush - Copley Medical Center Aurora, Illinois, United States, 60504
    • Saint Joseph Medical Center Bloomington, Illinois, United States, 61701
    • Illinois CancerCare-Bloomington Bloomington, Illinois, United States, 61704
    • Loyola Center for Health at Burr Ridge Burr Ridge, Illinois, United States, 60527
    • Illinois CancerCare-Canton Canton, Illinois, United States, 61520
    • Memorial Hospital of Carbondale Carbondale, Illinois, United States, 62902
    • SIH Cancer Institute Carterville, Illinois, United States, 62918
    • Illinois CancerCare-Carthage Carthage, Illinois, United States, 62321
    • Centralia Oncology Clinic Centralia, Illinois, United States, 62801
    • Northwestern University Chicago, Illinois, United States, 60611
    • Rush University Medical Center Chicago, Illinois, United States, 60612
    • University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637
    • Carle on Vermilion Danville, Illinois, United States, 61832
    • Cancer Care Specialists of Illinois - Decatur Decatur, Illinois, United States, 62526
    • Decatur Memorial Hospital Decatur, Illinois, United States, 62526
    • Northwestern Medicine Cancer Center Kishwaukee DeKalb, Illinois, United States, 60115
    • Illinois CancerCare-Dixon Dixon, Illinois, United States, 61021
    • Carle Physician Group-Effingham Effingham, Illinois, United States, 62401
    • Crossroads Cancer Center Effingham, Illinois, United States, 62401
    • Illinois CancerCare-Eureka Eureka, Illinois, United States, 61530
    • Illinois CancerCare-Galesburg Galesburg, Illinois, United States, 61401
    • Western Illinois Cancer Treatment Center Galesburg, Illinois, United States, 61401
    • Northwestern Medicine Cancer Center Delnor Geneva, Illinois, United States, 60134
    • Illinois CancerCare-Kewanee Clinic Kewanee, Illinois, United States, 61443
    • Northwestern Medicine Lake Forest Hospital Lake Forest, Illinois, United States, 60045
    • Illinois CancerCare-Macomb Macomb, Illinois, United States, 61455
    • Carle Physician Group-Mattoon/Charleston Mattoon, Illinois, United States, 61938
    • Loyola University Medical Center Maywood, Illinois, United States, 60153
    • Marjorie Weinberg Cancer Center at Loyola-Gottlieb Melrose Park, Illinois, United States, 60160
    • Good Samaritan Regional Health Center Mount Vernon, Illinois, United States, 62864
    • UC Comprehensive Cancer Center at Silver Cross New Lenox, Illinois, United States, 60451
    • Cancer Care Center of O'Fallon O'Fallon, Illinois, United States, 62269
    • Loyola Center for Cancer Care and Research Orland Park, Illinois, United States, 60462
    • University of Chicago Medicine-Orland Park Orland Park, Illinois, United States, 60462
    • Illinois CancerCare-Ottawa Clinic Ottawa, Illinois, United States, 61350
    • Radiation Oncology of Northern Illinois Ottawa, Illinois, United States, 61350
    • Illinois CancerCare-Pekin Pekin, Illinois, United States, 61554
    • OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin, Illinois, United States, 61554
    • Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615
    • OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria, Illinois, United States, 61615
    • Methodist Medical Center of Illinois Peoria, Illinois, United States, 61636
    • OSF Saint Francis Medical Center Peoria, Illinois, United States, 61637
    • Illinois CancerCare-Peru Peru, Illinois, United States, 61354
    • Valley Radiation Oncology Peru, Illinois, United States, 61354
    • Illinois CancerCare-Princeton Princeton, Illinois, United States, 61356
    • Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62702
    • Southern Illinois University School of Medicine Springfield, Illinois, United States, 62702
    • Springfield Clinic Springfield, Illinois, United States, 62702
    • Memorial Medical Center Springfield, Illinois, United States, 62781
    • Southwest Illinois Health Services LLP Swansea, Illinois, United States, 62226
    • Carle Cancer Center Urbana, Illinois, United States, 61801
    • The Carle Foundation Hospital Urbana, Illinois, United States, 61801
    • Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois, United States, 60555
    • Rush-Copley Healthcare Center Yorkville, Illinois, United States, 60560
  • United States, Indiana
    • Deaconess Clinic Downtown Evansville, Indiana, United States, 47713
    • Franciscan Saint Anthony Health-Michigan City Michigan City, Indiana, United States, 46360
    • Woodland Cancer Care Center Michigan City, Indiana, United States, 46360
    • Chancellor Center for Oncology Newburgh, Indiana, United States, 47630
    • Reid Health Richmond, Indiana, United States, 47374
  • United States, Iowa
    • Mary Greeley Medical Center Ames, Iowa, United States, 50010
    • McFarland Clinic PC - Ames Ames, Iowa, United States, 50010
    • McFarland Clinic PC-Boone Boone, Iowa, United States, 50036
    • Medical Oncology and Hematology Associates-West Des Moines Clive, Iowa, United States, 50325
    • Mercy Cancer Center-West Lakes Clive, Iowa, United States, 50325
    • Alegent Health Mercy Hospital Council Bluffs, Iowa, United States, 51503
    • Greater Regional Medical Center Creston, Iowa, United States, 50801
    • Medical Oncology and Hematology Associates-Laurel Des Moines, Iowa, United States, 50314
    • Mercy Medical Center - Des Moines Des Moines, Iowa, United States, 50314
    • McFarland Clinic PC-Trinity Cancer Center Fort Dodge, Iowa, United States, 50501
    • McFarland Clinic PC-Jefferson Jefferson, Iowa, United States, 50129
    • McFarland Clinic PC-Marshalltown Marshalltown, Iowa, United States, 50158
    • Siouxland Regional Cancer Center Sioux City, Iowa, United States, 51101
    • Mercy Medical Center-West Lakes West Des Moines, Iowa, United States, 50266
  • United States, Kansas
    • Cancer Center of Kansas - Chanute Chanute, Kansas, United States, 66720
    • Coffeyville Regional Medical Center Coffeyville, Kansas, United States, 67337
    • Cancer Center of Kansas - Dodge City Dodge City, Kansas, United States, 67801
    • Cancer Center of Kansas - El Dorado El Dorado, Kansas, United States, 67042
    • Cancer Center of Kansas - Fort Scott Fort Scott, Kansas, United States, 66701
    • Central Care Cancer Center - Garden City Garden City, Kansas, United States, 67846
    • Central Care Cancer Center - Great Bend Great Bend, Kansas, United States, 67530
    • HaysMed University of Kansas Health System Hays, Kansas, United States, 67601
    • Cancer Center of Kansas-Independence Independence, Kansas, United States, 67301
    • University of Kansas Cancer Center Kansas City, Kansas, United States, 66160
    • Cancer Center of Kansas-Kingman Kingman, Kansas, United States, 67068
    • Lawrence Memorial Hospital Lawrence, Kansas, United States, 66044
    • Kansas Institute of Medicine Cancer and Blood Center Lenexa, Kansas, United States, 66219
    • Minimally Invasive Surgery Hospital Lenexa, Kansas, United States, 66219
    • Cancer Center of Kansas-Liberal Liberal, Kansas, United States, 67905
    • Cancer Center of Kansas-Manhattan Manhattan, Kansas, United States, 66502
    • Cancer Center of Kansas - McPherson McPherson, Kansas, United States, 67460
    • Cancer Center of Kansas - Newton Newton, Kansas, United States, 67114
    • Olathe Health Cancer Center Olathe, Kansas, United States, 66061
    • Menorah Medical Center Overland Park, Kansas, United States, 66209
    • Cancer Center of Kansas - Parsons Parsons, Kansas, United States, 67357
    • Ascension Via Christi - Pittsburg Pittsburg, Kansas, United States, 66762
    • Cancer Center of Kansas - Pratt Pratt, Kansas, United States, 67124
    • Cancer Center of Kansas - Salina Salina, Kansas, United States, 67401
    • Salina Regional Health Center Salina, Kansas, United States, 67401
    • University of Kansas Health System Saint Francis Campus Topeka, Kansas, United States, 66606
    • Cancer Center of Kansas - Wellington Wellington, Kansas, United States, 67152
    • University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas, United States, 66205
    • Associates In Womens Health Wichita, Kansas, United States, 67208
    • Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas, United States, 67208
    • Ascension Via Christi Hospitals Wichita Wichita, Kansas, United States, 67214
    • Cancer Center of Kansas - Wichita Wichita, Kansas, United States, 67214
    • Cancer Center of Kansas - Winfield Winfield, Kansas, United States, 67156
  • United States, Kentucky
    • Flaget Memorial Hospital Bardstown, Kentucky, United States, 40004
    • Commonwealth Cancer Center-Corbin Corbin, Kentucky, United States, 40701
    • Oncology Hematology Care Inc-Crestview Crestview Hills, Kentucky, United States, 41017
    • Saint Joseph Radiation Oncology Resource Center Lexington, Kentucky, United States, 40504
    • Saint Joseph Hospital East Lexington, Kentucky, United States, 40509
    • University of Kentucky/Markey Cancer Center Lexington, Kentucky, United States, 40536
    • Saint Joseph London London, Kentucky, United States, 40741
    • Jewish Hospital Louisville, Kentucky, United States, 40202
    • Saints Mary and Elizabeth Hospital Louisville, Kentucky, United States, 40215
    • Jewish Hospital Medical Center Northeast Louisville, Kentucky, United States, 40245
    • Jewish Hospital Medical Center South Shepherdsville, Kentucky, United States, 40165
  • United States, Louisiana
    • Christus Saint Frances Cabrini Hospital Alexandria, Louisiana, United States, 71301
    • Ochsner Health Center-Summa Baton Rouge, Louisiana, United States, 70809
    • Medical Center of Baton Rouge Baton Rouge, Louisiana, United States, 70816
    • Ochsner High Grove Baton Rouge, Louisiana, United States, 70836
    • Ochsner Medical Center Kenner Kenner, Louisiana, United States, 70065
    • Ochsner LSU Health Monroe Medical Center Monroe, Louisiana, United States, 71202
    • Ochsner Medical Center Jefferson New Orleans, Louisiana, United States, 70121
    • LSU Health Sciences Center at Shreveport Shreveport, Louisiana, United States, 71103
  • United States, Maryland
    • Sinai Hospital of Baltimore Baltimore, Maryland, United States, 21215
    • Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287
    • Northwest Hospital Center Randallstown, Maryland, United States, 21133
    • William E Kahlert Regional Cancer Center/Sinai Hospital Westminster, Maryland, United States, 21157
  • United States, Massachusetts
    • Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114
    • Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215
    • Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215
    • Mercy Medical Center Springfield, Massachusetts, United States, 01104
  • United States, Michigan
    • Saint Joseph Mercy Hospital Ann Arbor, Michigan, United States, 48106
    • University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109
    • Bronson Battle Creek Battle Creek, Michigan, United States, 49017
    • IHA Hematology Oncology Consultants-Brighton Brighton, Michigan, United States, 48114
    • Saint Joseph Mercy Brighton Brighton, Michigan, United States, 48114
    • Henry Ford Cancer Institute-Downriver Brownstown, Michigan, United States, 48183
    • IHA Hematology Oncology Consultants-Canton Canton, Michigan, United States, 48188
    • Saint Joseph Mercy Canton Canton, Michigan, United States, 48188
    • Caro Cancer Center Caro, Michigan, United States, 48723
    • IHA Hematology Oncology Consultants-Chelsea Chelsea, Michigan, United States, 48118
    • Saint Joseph Mercy Chelsea Chelsea, Michigan, United States, 48118
    • Hematology Oncology Consultants-Clarkston Clarkston, Michigan, United States, 48346
    • Newland Medical Associates-Clarkston Clarkston, Michigan, United States, 48346
    • Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan, United States, 48038
    • Henry Ford Medical Center-Fairlane Dearborn, Michigan, United States, 48126
    • Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201
    • Henry Ford Hospital Detroit, Michigan, United States, 48202
    • Ascension Saint John Hospital Detroit, Michigan, United States, 48236
    • Great Lakes Cancer Management Specialists-Doctors Park East China Township, Michigan, United States, 48054
    • Weisberg Cancer Treatment Center Farmington Hills, Michigan, United States, 48334
    • Genesee Cancer and Blood Disease Treatment Center Flint, Michigan, United States, 48503
    • Genesee Hematology Oncology PC Flint, Michigan, United States, 48503
    • Genesys Hurley Cancer Institute Flint, Michigan, United States, 48503
    • Hurley Medical Center Flint, Michigan, United States, 48503
    • Helen DeVos Children's Hospital at Spectrum Health Grand Rapids, Michigan, United States, 49503
    • Mercy Health Saint Mary's Grand Rapids, Michigan, United States, 49503
    • Spectrum Health at Butterworth Campus Grand Rapids, Michigan, United States, 49503
    • Academic Hematology Oncology Specialists Grosse Pointe Woods, Michigan, United States, 48236
    • Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods, Michigan, United States, 48236
    • Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods, Michigan, United States, 48236
    • Allegiance Health Jackson, Michigan, United States, 49201
    • Bronson Methodist Hospital Kalamazoo, Michigan, United States, 49007
    • West Michigan Cancer Center Kalamazoo, Michigan, United States, 49007
    • Borgess Medical Center Kalamazoo, Michigan, United States, 49048
    • Sparrow Hospital Lansing, Michigan, United States, 48912
    • Hope Cancer Clinic Livonia, Michigan, United States, 48154
    • Saint Mary Mercy Hospital Livonia, Michigan, United States, 48154
    • Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb, Michigan, United States, 48044
    • Michigan Breast Specialists-Macomb Township Macomb, Michigan, United States, 48044
    • Saint Mary's Oncology/Hematology Associates of Marlette Marlette, Michigan, United States, 48453
    • Monroe Cancer Center Monroe, Michigan, United States, 48162
    • Mercy Health Mercy Campus Muskegon, Michigan, United States, 49444
    • Lakeland Hospital Niles Niles, Michigan, United States, 49120
    • Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores, Michigan, United States, 49444
    • Henry Ford Medical Center-Columbus Novi, Michigan, United States, 48377
    • 21st Century Oncology-Pontiac Pontiac, Michigan, United States, 48341
    • Hope Cancer Center Pontiac, Michigan, United States, 48341
    • Newland Medical Associates-Pontiac Pontiac, Michigan, United States, 48341
    • Saint Joseph Mercy Oakland Pontiac, Michigan, United States, 48341
    • Huron Medical Center PC Port Huron, Michigan, United States, 48060
    • Lake Huron Medical Center Port Huron, Michigan, United States, 48060
    • Spectrum Health Reed City Hospital Reed City, Michigan, United States, 49677
    • Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills, Michigan, United States, 48309
    • Ascension Saint Mary's Hospital Saginaw, Michigan, United States, 48601
    • Oncology Hematology Associates of Saginaw Valley PC Saginaw, Michigan, United States, 48604
    • Lakeland Medical Center Saint Joseph Saint Joseph, Michigan, United States, 49085
    • Marie Yeager Cancer Center Saint Joseph, Michigan, United States, 49085
    • Henry Ford Macomb Health Center - Shelby Township Shelby, Michigan, United States, 48315
    • Bhadresh Nayak MD PC-Sterling Heights Sterling Heights, Michigan, United States, 48312
    • Ascension Saint Joseph Hospital Tawas City, Michigan, United States, 48764
    • Munson Medical Center Traverse City, Michigan, United States, 49684
    • Advanced Breast Care Center PLLC Warren, Michigan, United States, 48088
    • Great Lakes Cancer Management Specialists-Macomb Professional Building Warren, Michigan, United States, 48093
    • Macomb Hematology Oncology PC Warren, Michigan, United States, 48093
    • Michigan Breast Specialists-Warren Warren, Michigan, United States, 48093
    • Saint John Macomb-Oakland Hospital Warren, Michigan, United States, 48093
    • Henry Ford West Bloomfield Hospital West Bloomfield, Michigan, United States, 48322
    • Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan, United States, 48661
    • Metro Health Hospital Wyoming, Michigan, United States, 49519
    • Huron Gastroenterology PC Ypsilanti, Michigan, United States, 48106
    • IHA Hematology Oncology Consultants-Ann Arbor Ypsilanti, Michigan, United States, 48197
  • United States, Minnesota
    • Sanford Joe Lueken Cancer Center Bemidji, Minnesota, United States, 56601
    • Fairview Ridges Hospital Burnsville, Minnesota, United States, 55337
    • Cambridge Medical Center Cambridge, Minnesota, United States, 55008
    • Mercy Hospital Coon Rapids, Minnesota, United States, 55433
    • Fairview Southdale Hospital Edina, Minnesota, United States, 55435
    • Unity Hospital Fridley, Minnesota, United States, 55432
    • Fairview Clinics and Surgery Center Maple Grove Maple Grove, Minnesota, United States, 55369
    • Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota, United States, 55109
    • Saint John's Hospital - Healtheast Maplewood, Minnesota, United States, 55109
    • Abbott-Northwestern Hospital Minneapolis, Minnesota, United States, 55407
    • Hennepin County Medical Center Minneapolis, Minnesota, United States, 55415
    • Health Partners Inc Minneapolis, Minnesota, United States, 55454
    • Monticello Cancer Center Monticello, Minnesota, United States, 55362
    • New Ulm Medical Center New Ulm, Minnesota, United States, 56073
    • Fairview Northland Medical Center Princeton, Minnesota, United States, 55371
    • North Memorial Medical Health Center Robbinsdale, Minnesota, United States, 55422
    • Mayo Clinic Rochester, Minnesota, United States, 55905
    • Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota, United States, 55416
    • Regions Hospital Saint Paul, Minnesota, United States, 55101
    • United Hospital Saint Paul, Minnesota, United States, 55102
    • Saint Francis Regional Medical Center Shakopee, Minnesota, United States, 55379
    • Lakeview Hospital Stillwater, Minnesota, United States, 55082
    • Sanford Thief River Falls Medical Center Thief River Falls, Minnesota, United States, 56701
    • Ridgeview Medical Center Waconia, Minnesota, United States, 55387
    • Rice Memorial Hospital Willmar, Minnesota, United States, 56201
    • Minnesota Oncology Hematology PA-Woodbury Woodbury, Minnesota, United States, 55125
    • Sanford Cancer Center Worthington Worthington, Minnesota, United States, 56187
    • Fairview Lakes Medical Center Wyoming, Minnesota, United States, 55092
  • United States, Missouri
    • Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri, United States, 63011
    • Central Care Cancer Center - Bolivar Bolivar, Missouri, United States, 65613
    • Parkland Health Center-Bonne Terre Bonne Terre, Missouri, United States, 63628
    • Cox Cancer Center Branson Branson, Missouri, United States, 65616
    • Saint Francis Medical Center Cape Girardeau, Missouri, United States, 63703
    • Southeast Cancer Center Cape Girardeau, Missouri, United States, 63703
    • Siteman Cancer Center at West County Hospital Creve Coeur, Missouri, United States, 63141
    • Parkland Health Center - Farmington Farmington, Missouri, United States, 63640
    • Centerpoint Medical Center LLC Independence, Missouri, United States, 64057
    • Capital Region Southwest Campus Jefferson City, Missouri, United States, 65109
    • Freeman Health System Joplin, Missouri, United States, 64804
    • Mercy Hospital Joplin Joplin, Missouri, United States, 64804
    • Truman Medical Centers Kansas City, Missouri, United States, 64108
    • Research Medical Center Kansas City, Missouri, United States, 64132
    • Delbert Day Cancer Institute at PCRMC Rolla, Missouri, United States, 65401
    • Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri, United States, 65401
    • Heartland Regional Medical Center Saint Joseph, Missouri, United States, 64506
    • Saint Louis Cancer and Breast Institute-South City Saint Louis, Missouri, United States, 63109
    • Washington University School of Medicine Saint Louis, Missouri, United States, 63110
    • Mercy Hospital South Saint Louis, Missouri, United States, 63128
    • Siteman Cancer Center-South County Saint Louis, Missouri, United States, 63129
    • Missouri Baptist Medical Center Saint Louis, Missouri, United States, 63131
    • Siteman Cancer Center at Christian Hospital Saint Louis, Missouri, United States, 63136
    • Mercy Hospital Saint Louis Saint Louis, Missouri, United States, 63141
    • Siteman Cancer Center at Saint Peters Hospital Saint Peters, Missouri, United States, 63376
    • Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri, United States, 63670
    • Mercy Hospital Springfield Springfield, Missouri, United States, 65804
    • CoxHealth South Hospital Springfield, Missouri, United States, 65807
    • Missouri Baptist Sullivan Hospital Sullivan, Missouri, United States, 63080
    • Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills, Missouri, United States, 63127
    • Mercy Hospital Washington Washington, Missouri, United States, 63090
  • United States, Montana
    • Community Hospital of Anaconda Anaconda, Montana, United States, 59711
    • Billings Clinic Cancer Center Billings, Montana, United States, 59101
    • Saint Vincent Healthcare Billings, Montana, United States, 59101
    • Bozeman Deaconess Hospital Bozeman, Montana, United States, 59715
    • Saint James Community Hospital and Cancer Treatment Center Butte, Montana, United States, 59701
    • Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana, United States, 59405
    • Great Falls Clinic Great Falls, Montana, United States, 59405
    • Saint Peter's Community Hospital Helena, Montana, United States, 59601
    • Kalispell Regional Medical Center Kalispell, Montana, United States, 59901
    • Saint Patrick Hospital - Community Hospital Missoula, Montana, United States, 59802
    • Community Medical Hospital Missoula, Montana, United States, 59804
  • United States, Nebraska
    • CHI Health Saint Francis Grand Island, Nebraska, United States, 68803
    • Heartland Hematology and Oncology Kearney, Nebraska, United States, 68845
    • CHI Health Good Samaritan Kearney, Nebraska, United States, 68847
    • Saint Elizabeth Regional Medical Center Lincoln, Nebraska, United States, 68510
    • Alegent Health Immanuel Medical Center Omaha, Nebraska, United States, 68122
    • Hematology and Oncology Consultants PC Omaha, Nebraska, United States, 68122
    • Alegent Health Bergan Mercy Medical Center Omaha, Nebraska, United States, 68124
    • Alegent Health Lakeside Hospital Omaha, Nebraska, United States, 68130
    • Creighton University Medical Center Omaha, Nebraska, United States, 68131
    • Midlands Community Hospital Papillion, Nebraska, United States, 68046
  • United States, Nevada
    • Carson Tahoe Regional Medical Center Carson City, Nevada, United States, 89703
    • Cancer and Blood Specialists-Henderson Henderson, Nevada, United States, 89052
    • Comprehensive Cancer Centers of Nevada - Henderson Henderson, Nevada, United States, 89052
    • Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson, Nevada, United States, 89052
    • Las Vegas Cancer Center-Henderson Henderson, Nevada, United States, 89052
    • OptumCare Cancer Care at Seven Hills Henderson, Nevada, United States, 89052
    • 21st Century Oncology-Henderson Henderson, Nevada, United States, 89074
    • Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson, Nevada, United States, 89074
    • Las Vegas Urology - Green Valley Henderson, Nevada, United States, 89074
    • Las Vegas Urology - Pebble Henderson, Nevada, United States, 89074
    • Urology Specialists of Nevada - Green Valley Henderson, Nevada, United States, 89074
    • Las Vegas Urology - Pecos Las Vegas, Nevada, United States, 89074
    • Desert West Surgery Las Vegas, Nevada, United States, 89102
    • OptumCare Cancer Care at Oakey Las Vegas, Nevada, United States, 89102
    • University Medical Center of Southern Nevada Las Vegas, Nevada, United States, 89102
    • Hope Cancer Care of Nevada Las Vegas, Nevada, United States, 89103
    • Cancer and Blood Specialists-Shadow Las Vegas, Nevada, United States, 89106
    • Radiation Oncology Centers of Nevada Central Las Vegas, Nevada, United States, 89106
    • Urology Specialists of Nevada - Central Las Vegas, Nevada, United States, 89106
    • 21st Century Oncology Las Vegas, Nevada, United States, 89109
    • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas, Nevada, United States, 89109
    • Sunrise Hospital and Medical Center Las Vegas, Nevada, United States, 89109
    • HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas, Nevada, United States, 89113
    • Las Vegas Prostate Cancer Center Las Vegas, Nevada, United States, 89113
    • Las Vegas Urology - Sunset Las Vegas, Nevada, United States, 89113
    • Radiation Oncology Centers of Nevada Southeast Las Vegas, Nevada, United States, 89119
    • Cancer Therapy and Integrative Medicine Las Vegas, Nevada, United States, 89121
    • 21st Century Oncology-Vegas Tenaya Las Vegas, Nevada, United States, 89128
    • Ann M Wierman MD LTD Las Vegas, Nevada, United States, 89128
    • Cancer and Blood Specialists-Tenaya Las Vegas, Nevada, United States, 89128
    • Comprehensive Cancer Centers of Nevada - Northwest Las Vegas, Nevada, United States, 89128
    • HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas, Nevada, United States, 89128
    • Las Vegas Urology - Cathedral Rock Las Vegas, Nevada, United States, 89128
    • Las Vegas Urology - Smoke Ranch Las Vegas, Nevada, United States, 89128
    • OptumCare Cancer Care at MountainView Las Vegas, Nevada, United States, 89128
    • Urology Specialists of Nevada - Northwest Las Vegas, Nevada, United States, 89128
    • Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada, United States, 89135
    • Comprehensive Cancer Centers of Nevada - Town Center Las Vegas, Nevada, United States, 89144
    • Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas, Nevada, United States, 89144
    • Summerlin Hospital Medical Center Las Vegas, Nevada, United States, 89144
    • Las Vegas Cancer Center-Medical Center Las Vegas, Nevada, United States, 89148-2405
    • 21st Century Oncology-Fort Apache Las Vegas, Nevada, United States, 89148
    • Comprehensive Cancer Centers of Nevada Las Vegas, Nevada, United States, 89148
    • OptumCare Cancer Care at Fort Apache Las Vegas, Nevada, United States, 89148
    • Urology Specialists of Nevada - Southwest Las Vegas, Nevada, United States, 89148
    • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas, Nevada, United States, 89149
    • Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas, Nevada, United States, 89169
    • University Cancer Center Las Vegas, Nevada, United States, 89169
    • Hope Cancer Care of Nevada-Pahrump Pahrump, Nevada, United States, 89048
    • Renown Regional Medical Center Reno, Nevada, United States, 89502
    • Saint Mary's Regional Medical Center Reno, Nevada, United States, 89503
    • Radiation Oncology Associates Reno, Nevada, United States, 89509
  • United States, New Hampshire
    • Dartmouth Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756
  • United States, New Jersey
    • Inspira Medical Center Vineland Vineland, New Jersey, United States, 08360
    • Inspira Medical Center Woodbury Woodbury, New Jersey, United States, 08096
  • United States, New Mexico
    • University of New Mexico Cancer Center Albuquerque, New Mexico, United States, 87102
  • United States, New York
    • Montefiore Medical Center-Einstein Campus Bronx, New York, United States, 10461
    • Montefiore Medical Center-Weiler Hospital Bronx, New York, United States, 10461
    • Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467
    • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York, New York, United States, 10032
  • United States, North Carolina
    • AdventHealth Infusion Center Asheville Asheville, North Carolina, United States, 28803
    • Duke Cancer Institute Cary Cary, North Carolina, United States, 27518
    • Southeastern Medical Oncology Center-Clinton Clinton, North Carolina, United States, 28328
    • AdventHealth Infusion Center Haywood Clyde, North Carolina, United States, 28721
    • Duke University Medical Center Durham, North Carolina, United States, 27710
    • Southeastern Medical Oncology Center-Goldsboro Goldsboro, North Carolina, United States, 27534
    • Wayne Memorial Hospital Goldsboro, North Carolina, United States, 27534
    • AdventHealth Hendersonville Hendersonville, North Carolina, United States, 28792
    • Onslow Memorial Hospital Jacksonville, North Carolina, United States, 28546
    • Southeastern Medical Oncology Center-Jacksonville Jacksonville, North Carolina, United States, 28546
    • Duke Raleigh Hospital Raleigh, North Carolina, United States, 27609
    • Marion L Shepard Cancer Center at Vidant Beaufort Hospital Washington, North Carolina, United States, 27889
  • United States, North Dakota
    • Sanford Bismarck Medical Center Bismarck, North Dakota, United States, 58501
    • Sanford South University Medical Center Fargo, North Dakota, United States, 58103
    • Sanford Broadway Medical Center Fargo, North Dakota, United States, 58122
    • Sanford Clinic North-Fargo Fargo, North Dakota, United States, 58122
    • Sanford Roger Maris Cancer Center Fargo, North Dakota, United States, 58122
  • United States, Ohio
    • UHHS-Chagrin Highlands Medical Center Beachwood, Ohio, United States, 44122
    • Indu and Raj Soin Medical Center Beavercreek, Ohio, United States, 45431
    • Strecker Cancer Center-Belpre Belpre, Ohio, United States, 45714
    • Saint Elizabeth Boardman Hospital Boardman, Ohio, United States, 44512
    • Dayton Physicians LLC-Miami Valley South Centerville, Ohio, United States, 45459
    • Miami Valley Hospital South Centerville, Ohio, United States, 45459
    • Geauga Hospital Chardon, Ohio, United States, 44024
    • Adena Regional Medical Center Chillicothe, Ohio, United States, 45601
    • Oncology Hematology Care Inc-Eden Park Cincinnati, Ohio, United States, 45202
    • Oncology Hematology Care Inc-Mercy West Cincinnati, Ohio, United States, 45211
    • University of Cincinnati/Barrett Cancer Center Cincinnati, Ohio, United States, 45219
    • Good Samaritan Hospital - Cincinnati Cincinnati, Ohio, United States, 45220
    • Oncology Hematology Care Inc-Anderson Cincinnati, Ohio, United States, 45230
    • Oncology Hematology Care Inc-Kenwood Cincinnati, Ohio, United States, 45236
    • Bethesda North Hospital Cincinnati, Ohio, United States, 45242
    • Oncology Hematology Care Inc-Blue Ash Cincinnati, Ohio, United States, 45242
    • TriHealth Cancer Institute-Westside Cincinnati, Ohio, United States, 45247
    • TriHealth Cancer Institute-Anderson Cincinnati, Ohio, United States, 45255
    • Case Western Reserve University Cleveland, Ohio, United States, 44106
    • MetroHealth Medical Center Cleveland, Ohio, United States, 44109
    • Cleveland Clinic Cancer Center/Fairview Hospital Cleveland, Ohio, United States, 44111
    • Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195
    • Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210
    • Mount Carmel East Hospital Columbus, Ohio, United States, 43213
    • Columbus Oncology and Hematology Associates Inc Columbus, Ohio, United States, 43214
    • Riverside Methodist Hospital Columbus, Ohio, United States, 43214
    • Grant Medical Center Columbus, Ohio, United States, 43215
    • The Mark H Zangmeister Center Columbus, Ohio, United States, 43219
    • Mount Carmel Health Center West Columbus, Ohio, United States, 43222
    • Doctors Hospital Columbus, Ohio, United States, 43228
    • Good Samaritan Hospital - Dayton Dayton, Ohio, United States, 45406
    • Miami Valley Hospital Dayton, Ohio, United States, 45409
    • Dayton Physician LLC-Miami Valley Hospital North Dayton, Ohio, United States, 45415
    • Miami Valley Hospital North Dayton, Ohio, United States, 45415
    • Delaware Health Center-Grady Cancer Center Delaware, Ohio, United States, 43015
    • Delaware Radiation Oncology Delaware, Ohio, United States, 43015
    • Grady Memorial Hospital Delaware, Ohio, United States, 43015
    • Dublin Methodist Hospital Dublin, Ohio, United States, 43016
    • Mercy Cancer Center-Elyria Elyria, Ohio, United States, 44035
    • Oncology Hematology Care Inc-Healthplex Fairfield, Ohio, United States, 45014
    • Armes Family Cancer Center Findlay, Ohio, United States, 45840
    • Blanchard Valley Hospital Findlay, Ohio, United States, 45840
    • Orion Cancer Care Findlay, Ohio, United States, 45840
    • Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio, United States, 45005-1066
    • Dayton Physicians LLC-Atrium Franklin, Ohio, United States, 45005
    • Dayton Physicians LLC-Wayne Greenville, Ohio, United States, 45331
    • Wayne Hospital Greenville, Ohio, United States, 45331
    • Mount Carmel Grove City Hospital Grove City, Ohio, United States, 43123
    • Cleveland Clinic Cancer Center Independence Independence, Ohio, United States, 44131
    • Greater Dayton Cancer Center Kettering, Ohio, United States, 45409
    • First Dayton Cancer Care Kettering, Ohio, United States, 45420
    • Kettering Medical Center Kettering, Ohio, United States, 45429
    • Fairfield Medical Center Lancaster, Ohio, United States, 43130
    • OhioHealth Mansfield Hospital Mansfield, Ohio, United States, 44903
    • Marietta Memorial Hospital Marietta, Ohio, United States, 45750
    • OhioHealth Marion General Hospital Marion, Ohio, United States, 43302
    • Hillcrest Hospital Cancer Center Mayfield Heights, Ohio, United States, 44124
    • UH Seidman Cancer Center at Landerbrook Health Center Mayfield Heights, Ohio, United States, 44124
    • UH Seidman Cancer Center at Lake Health Mentor Campus Mentor, Ohio, United States, 44060
    • UH Seidman Cancer Center at Southwest General Hospital Middleburg Heights, Ohio, United States, 44130
    • Dayton Physicians LLC-Signal Point Middletown, Ohio, United States, 45042
    • Knox Community Hospital Mount Vernon, Ohio, United States, 43050
    • Licking Memorial Hospital Newark, Ohio, United States, 43055
    • Newark Radiation Oncology Newark, Ohio, United States, 43055
    • University Hospitals Parma Medical Center Parma, Ohio, United States, 44129
    • Southern Ohio Medical Center Portsmouth, Ohio, United States, 45662
    • North Coast Cancer Care Sandusky, Ohio, United States, 44870
    • UH Seidman Cancer Center at Firelands Regional Medical Center Sandusky, Ohio, United States, 44870
    • Dayton Physicians LLC-Wilson Sidney, Ohio, United States, 45365
    • Springfield Regional Cancer Center Springfield, Ohio, United States, 45504
    • Springfield Regional Medical Center Springfield, Ohio, United States, 45505
    • Cleveland Clinic Cancer Center Strongsville Strongsville, Ohio, United States, 44136
    • ProMedica Flower Hospital Sylvania, Ohio, United States, 43560
    • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo, Ohio, United States, 43606
    • Dayton Physicians LLC-Upper Valley Troy, Ohio, United States, 45373
    • Upper Valley Medical Center Troy, Ohio, United States, 45373
    • University Hospitals Sharon Health Center Wadsworth, Ohio, United States, 44281
    • South Pointe Hospital Warrensville Heights, Ohio, United States, 44122
    • Saint Joseph Warren Hospital Warren, Ohio, United States, 44484
    • University Pointe West Chester, Ohio, United States, 45069
    • Saint Ann's Hospital Westerville, Ohio, United States, 43081
    • UH Seidman Cancer Center at Saint John Medical Center Westlake, Ohio, United States, 44145
    • UHHS-Westlake Medical Center Westlake, Ohio, United States, 44145
    • Cleveland Clinic Wooster Family Health and Surgery Center Wooster, Ohio, United States, 44691
    • Saint Elizabeth Youngstown Hospital Youngstown, Ohio, United States, 44501
    • Genesis Healthcare System Cancer Care Center Zanesville, Ohio, United States, 43701
  • United States, Oklahoma
    • Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma, United States, 73505
    • University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, United States, 73104
    • Mercy Hospital Oklahoma City Oklahoma City, Oklahoma, United States, 73120
  • United States, Oregon
    • Saint Alphonsus Medical Center-Baker City Baker City, Oregon, United States, 97814
    • Saint Alphonsus Medical Center-Ontario Ontario, Oregon, United States, 97914
  • United States, Pennsylvania
    • Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania, United States, 18103
    • UPMC-Heritage Valley Health System Beaver Beaver, Pennsylvania, United States, 15009
    • Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania, United States, 18017
    • Christiana Care Health System-Concord Health Center Chadds Ford, Pennsylvania, United States, 19317
    • Geisinger Medical Center Danville, Pennsylvania, United States, 17822
    • Pocono Medical Center East Stroudsburg, Pennsylvania, United States, 18301
    • UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg, Pennsylvania, United States, 15601
    • Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania, United States, 18201
    • Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania, United States, 18201
    • Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850
    • UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown, Pennsylvania, United States, 15901
    • Geisinger Medical Oncology-Lewisburg Lewisburg, Pennsylvania, United States, 17837
    • Lewistown Hospital Lewistown, Pennsylvania, United States, 17044
    • UPMC Cancer Center at UPMC McKeesport McKeesport, Pennsylvania, United States, 15132
    • UPMC-Coraopolis/Heritage Valley Radiation Oncology Moon, Pennsylvania, United States, 15108
    • University of Pennsylvania/Abramson Cancer Center Philadelphia, Pennsylvania, United States, 19104
    • Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111
    • UPMC-Magee Womens Hospital Pittsburgh, Pennsylvania, United States, 15213
    • UPMC-Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213
    • UPMC-Saint Margaret Pittsburgh, Pennsylvania, United States, 15215
    • University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232
    • UPMC-Shadyside Hospital Pittsburgh, Pennsylvania, United States, 15232
    • UPMC Jefferson Regional Radiation Oncology Pittsburgh, Pennsylvania, United States, 15236
    • UPMC-Passavant Hospital Pittsburgh, Pennsylvania, United States, 15237
    • UPMC-Saint Clair Hospital Cancer Center Pittsburgh, Pennsylvania, United States, 15243
    • Geisinger Cancer Services-Pottsville Pottsville, Pennsylvania, United States, 17901
    • Community Medical Center Scranton, Pennsylvania, United States, 18510
    • Geisinger Medical Oncology-Selinsgrove Selinsgrove, Pennsylvania, United States, 17870
    • UPMC Cancer Center at UPMC Northwest Seneca, Pennsylvania, United States, 16346
    • Geisinger Medical Group State College, Pennsylvania, United States, 16801
    • UPMC Uniontown Hospital Radiation Oncology Uniontown, Pennsylvania, United States, 15401
    • UPMC Washington Hospital Radiation Oncology Washington, Pennsylvania, United States, 15301
    • Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre, Pennsylvania, United States, 18711
  • United States, South Carolina
    • AnMed Health Cancer Center Anderson, South Carolina, United States, 29621
    • Medical University of South Carolina Charleston, South Carolina, United States, 29425
    • Prisma Health Cancer Institute - Easley Easley, South Carolina, United States, 29640
    • Prisma Health Cancer Institute - Butternut Greenville, South Carolina, United States, 29605
    • Prisma Health Cancer Institute - Faris Greenville, South Carolina, United States, 29605
    • Prisma Health Greenville Memorial Hospital Greenville, South Carolina, United States, 29605
    • Prisma Health Cancer Institute - Eastside Greenville, South Carolina, United States, 29615
    • Prisma Health Cancer Institute - Greer Greer, South Carolina, United States, 29650
    • Prisma Health Cancer Institute - Seneca Seneca, South Carolina, United States, 29672
    • Prisma Health Cancer Institute - Spartanburg Spartanburg, South Carolina, United States, 29307
  • United States, South Dakota
    • Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota, United States, 57104
    • Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota, United States, 57117-5134
  • United States, Tennessee
    • Memorial Hospital Chattanooga, Tennessee, United States, 37404
    • Pulmonary Medicine Center of Chattanooga-Hixson Hixson, Tennessee, United States, 37343
    • Memorial GYN Plus Ooltewah, Tennessee, United States, 37363
  • United States, Texas
    • Saint Joseph Regional Cancer Center Bryan, Texas, United States, 77802
    • Parkland Memorial Hospital Dallas, Texas, United States, 75235
    • UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas, United States, 75390
    • UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth, Texas, United States, 76104
    • Houston Methodist Hospital Houston, Texas, United States, 77030
    • Methodist Willowbrook Hospital Houston, Texas, United States, 77070
    • UT Southwestern Clinical Center at Richardson/Plano Richardson, Texas, United States, 75080
    • University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229
    • Houston Methodist Sugar Land Hospital Sugar Land, Texas, United States, 77479
  • United States, Utah
    • Farmington Health Center Farmington, Utah, United States, 84025
    • University of Utah Sugarhouse Health Center Salt Lake City, Utah, United States, 84106
    • Huntsman Cancer Institute/University of Utah Salt Lake City, Utah, United States, 84112
  • United States, Washington
    • Overlake Hospital Medical Center Bellevue, Washington, United States, 98004
    • Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton, Washington, United States, 98310
    • Harrison Medical Center Bremerton, Washington, United States, 98310
    • Highline Medical Center-Main Campus Burien, Washington, United States, 98166
    • Saint Elizabeth Hospital Enumclaw, Washington, United States, 98022
    • Saint Francis Hospital Federal Way, Washington, United States, 98003
    • Saint Clare Hospital Lakewood, Washington, United States, 98499
    • Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo, Washington, United States, 98370
    • Valley Medical Center Renton, Washington, United States, 98055
    • Franciscan Research Center-Northwest Medical Plaza Tacoma, Washington, United States, 98405
    • Northwest Medical Specialties PLLC Tacoma, Washington, United States, 98405
  • United States, Wisconsin
    • Aurora Cancer Care-Southern Lakes VLCC Burlington, Wisconsin, United States, 53105
    • Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin, United States, 54729
    • Marshfield Clinic Cancer Center at Sacred Heart Eau Claire, Wisconsin, United States, 54701
    • Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin, United States, 54701
    • Aurora Health Center-Fond du Lac Fond Du Lac, Wisconsin, United States, 54937
    • Aurora Health Care Germantown Health Center Germantown, Wisconsin, United States, 53022
    • Aurora Cancer Care-Grafton Grafton, Wisconsin, United States, 53024
    • Aurora BayCare Medical Center Green Bay, Wisconsin, United States, 54311
    • UW Cancer Center Johnson Creek Johnson Creek, Wisconsin, United States, 53038
    • Aurora Cancer Care-Kenosha South Kenosha, Wisconsin, United States, 53142
    • Marshfield Clinic - Ladysmith Center Ladysmith, Wisconsin, United States, 54848
    • University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792
    • Aurora Bay Area Medical Group-Marinette Marinette, Wisconsin, United States, 54143
    • Bay Area Medical Center Marinette, Wisconsin, United States, 54143
    • Marshfield Medical Center-Marshfield Marshfield, Wisconsin, United States, 54449
    • Aurora Cancer Care-Milwaukee Milwaukee, Wisconsin, United States, 53209
    • Aurora Saint Luke's Medical Center Milwaukee, Wisconsin, United States, 53215
    • Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226
    • Aurora Sinai Medical Center Milwaukee, Wisconsin, United States, 53233
    • Marshfield Clinic-Minocqua Center Minocqua, Wisconsin, United States, 54548
    • Cancer Center of Western Wisconsin New Richmond, Wisconsin, United States, 54017
    • Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin, United States, 54904
    • Aurora Cancer Care-Racine Racine, Wisconsin, United States, 53406
    • Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin, United States, 54868
    • Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin, United States, 53081
    • Ascension Saint Michael's Hospital Stevens Point, Wisconsin, United States, 54481
    • Marshfield Clinic Stevens Point Center Stevens Point, Wisconsin, United States, 54482
    • Aurora Medical Center in Summit Summit, Wisconsin, United States, 53066
    • Vince Lombardi Cancer Clinic-Two Rivers Two Rivers, Wisconsin, United States, 54241
    • Aurora Cancer Care-Waukesha Waukesha, Wisconsin, United States, 53188
    • Marshfield Clinic-Wausau Center Wausau, Wisconsin, United States, 54401
    • Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin, United States, 53226
    • Aurora West Allis Medical Center West Allis, Wisconsin, United States, 53227
    • Marshfield Clinic - Weston Center Weston, Wisconsin, United States, 54476
    • Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin, United States, 54494
  • United States, Wyoming
    • Big Horn Basin Cancer Center Cody, Wyoming, United States, 82414
    • Billings Clinic-Cody Cody, Wyoming, United States, 82414
    • Welch Cancer Center Sheridan, Wyoming, United States, 82801

Sponsors and Collaborators

ECOG-ACRIN Cancer Research Group

National Cancer Institute (NCI)

More Information

No publications provided

Responsible Party: Sponsor
ClinicalTrials.gov Identifier: NCT02595424
Other Study ID Numbers: NCI-2015-00547
Study First Received:
Last Updated:
Health Authority:

Additional relevant MeSH terms:

Carcinoma

Carcinoma, Neuroendocrine

Carcinoma, Islet Cell

Cisplatin

Carboplatin

Capecitabine

Etoposide

Temozolomide

Next Steps


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ClinicalTrials.gov processed this data on February 25, 2021