Clinical Trial - NCT02176967

Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma

Recruiting

Sponsor: Children's Oncology Group

Collaborators: National Cancer Institute (NCI)

Information provided by (Responsible party): Sponsor

ClinicalTrials.gov Identifier: NCT02176967

Protocol Info

Short Description: COG ANBL1232: Non-High Risk Neuroblastoma
Long Description: COG ANBL1232: Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma
MGH Status: Open
Sponsor: Coop/COG
Disease Program: Pediatrics

Next Steps


If you are interested in this protocol or in other treatment options at Massachusetts General Hospital, please Request a Consultation.




Purpose

This phase III trial studies how well response and biology-based risk factor-guided therapy works in treating younger patients with non-high risk neuroblastoma. Sometimes a tumor may not need treatment until it progresses. In this case, observation may be sufficient. Measuring biomarkers in tumor cells may help plan when effective treatment is necessary and what the best treatment is. Response and biology-based risk factor-guided therapy may be effective in treating patients with non-high risk neuroblastoma and may help to avoid some of the risks and side effects related to standard treatment.
Condition Title Intervention Phase
Ganglioneuroblastoma Localized Resectable Neuroblastoma Localized Unresectable Neuroblastoma Neuroblastoma Carboplatin Clinical Observation Cyclophosphamide Doxorubicin Hydrochloride Etoposide Laboratory Biomarker Analysis Pharmacological Study Phase 3
Study Type Interventional
Official Title Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients With Non-High-Risk Neuroblastoma

Primary Outcome Measures

Overall survival (OS) (Strata 1-4) [Time Frame: 3 years] [Designated as safety issue: ]


Secondary Outcome Measures

Estimated Enrollment: 621
Study Start Date: July 2014
Estimated Study Completion Date:
Estimated Primary Completion Date: September 2025
Arms Assigned Interventions

Experimental:Group A (clinical observation)

Patients undergo clinical observation for 96 weeks in the absence of disease progression.
Other:Pharmacological Study
Optional correlative studies

Experimental:Group B (clinical observation, first-line chemotherapy)

Patients undergo clinical observation for 3 years in the absence of disease progression. Upon disease progression, patients undergo surgery or receive first-line chemotherapy comprising carboplatin IV over 1 hour on day 1 (courses 1, 2, 4, 6, and 7), etoposide IV over 1 hour on days 1-3 (courses 1, 3, 4, 5, and 7), cyclophosphamide IV over 1 hour on day 1 (courses 2, 3, 5, 6, and 8), and doxorubicin hydrochloride IV over 15 minutes on day 1 (courses 2, 4, 6 and 8). Treatment with chemotherapy repeats every 21 days for 2-8 courses in the absence of disease progression or unacceptable toxicity. Once a PR or better is achieved, patients undergo clinical observation for 3 years.
Drug:Etoposide
Given IV

Experimental:Group C (clinical observation, first-line chemotherapy)

Patients at high risk for deterioration and a poor outcome immediately receive first-line chemotherapy as in Group B. All other patients undergo clinical observation for 3 years in the absence of disease progression. Upon disease progression, patients receive first-line chemotherapy as in Group B. Once a PR or better is achieved, patients undergo clinical observation for 3 years.

Eligibility

Ages Eligible for Study: 18 Months-18 Months

Genders Eligible for Study: All

Accepts Healthly Volunteers: No

Inclusion Criteria:

  • Patients must be:
  • < 12 months (< 365 days) of age at diagnosis with INRG stage L1; or
  • < 18 months (< 547 days) of age at diagnosis with INRG stage L2 or stage Ms neuroblastoma/ganglioneuroblastoma
  • Enrollment on ANBL00B1 or APEC14B1 is required for all newly diagnosed patients
  • Patients must have newly diagnosed v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) non-amplified neuroblastoma (International Classification of Diseases for Oncology [ICD-O] morphology 9500/3) or MYCN non-amplified ganglioneuroblastoma verified by histology
  • Patients must meet the specified criteria for one of the treatment groups defined below; genomic features include MYCN gene amplification, segmental chromosome aberrations (somatic copy number loss at 1p, 3p, 4p, or 11q or somatic copy number gain at 1q, 2p, or 17q) and deoxyribonucleic acid (DNA) index
  • ?Favorable? genomic features are defined by one or more whole-chromosome gains or hyperdiploid tumor (DNA index > 1) in the absence of segmental chromosome aberrations as defined above
  • ?Unfavorable? genomic features are defined by the presence of any segmental chromosome aberration (somatic copy number loss at 1p, 3p, 4p, or 11q or somatic copy number gain at 1q, 2p, or 17q) or diploid tumor (DNA index = 1); this includes copy neutral loss of heterozygosity (LOH)
  • Only patients with MYCN non-amplified tumors are eligible for this study
  • Group A: patients < 12 months (< 365 days) of age with newly diagnosed INRG stage L1 neuroblastoma/ganglioneuroblastoma who meet the following criteria:
  • Greatest tumor diameter < 5 cm of adrenal or non-adrenal origin
  • Patients with non-adrenal primaries are eligible, but must have positive uptake on metaiodobenzylguanidine (MIBG) scan or elevated catecholamine metabolites (urine or serum) to support the diagnosis of neuroblastoma
  • No prior tumor resection or biopsy
  • Group A will be further split into two subsets, which are mutually exclusive, for statistical purposes
  • Group A1:
  • > 6 months and < 12 months of age with an adrenal primary tumor < 5 cm in greatest diameter OR
  • Patients less than 6 months of age with an adrenal primary tumor > 3.1 and < 5 cm in greatest diameter OR
  • < 12 months of age with a non-adrenal primary site < 5 cm in greatest diameter
  • Group A2: =< 6 months of age with an adrenal primary site and tumor =< 3.1 cm in greatest diameter.
  • Group B: patients < 18 months (< 547 days) of age with newly diagnosed INRG stage L2 neuroblastoma/ganglioneuroblastoma who meet the following criteria:
  • No life threatening symptoms or no impending neurologic or other organ function compromise (e.g. epidural or intraspinal tumors with existing or impending neurologic impairment, periorbital or calvarial-based lesions with existing or impending cranial nerve impairment, anatomic or mechanical compromise of critical organ function by tumor [abdominal compartment syndrome, urinary obstruction, etc.]); horner syndrome is not considered neurologic compromise
  • No prior tumor resection, tumor biopsy ONLY
  • Only patients with both favorable histology and favorable genomic features will remain on study as part of Group B; the institution will be notified of histologic and genomic results within 3 weeks of specimen submission on ANBL00B1 or APEC14B1
  • Group C: patients < 18 months (< 547 days) of age with newly diagnosed INRG stage Ms neuroblastoma/ganglioneuroblastoma
  • No prior radiotherapy or chemotherapy, with the exception of dexamethasone, which is allowed
  • All patients and/or their parents or legal guardians must sign a written informed consent
  • All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Exclusion Criteria:

  • Patients with MYCN amplified tumors are not eligible
  • Group B and C patients who do not enroll on ANBL1232 within 4 weeks of definitive diagnostic procedure
  • Group A and C patients, not required to undergo tumor biopsy, who do not enroll on ANBL1232 within 4 weeks of confirmatory imaging study

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT02176967

Locations

  • United States, Alabama
    • Children's Hospital of Alabama Birmingham, Alabama, United States, 35233
    • USA Health Strada Patient Care Center Mobile, Alabama, United States, 36604
  • United States, Alaska
    • Providence Alaska Medical Center Anchorage, Alaska, United States, 99508
  • United States, Arizona
    • Cardon Children's Medical Center Mesa, Arizona, United States, 85202
    • Phoenix Childrens Hospital Phoenix, Arizona, United States, 85016
    • Banner University Medical Center - Tucson Tucson, Arizona, United States, 85719
  • United States, Arkansas
    • Arkansas Children's Hospital Little Rock, Arkansas, United States, 72202-3591
  • United States, California
    • Kaiser Permanente Downey Medical Center Downey, California, United States, 90242
    • City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010
    • Loma Linda University Medical Center Loma Linda, California, United States, 92354
    • Miller Children's and Women's Hospital Long Beach Long Beach, California, United States, 90806
    • Children's Hospital Los Angeles Los Angeles, California, United States, 90027
    • Cedars Sinai Medical Center Los Angeles, California, United States, 90048
    • Valley Children's Hospital Madera, California, United States, 93636
    • Children's Hospital and Research Center at Oakland Oakland, California, United States, 94609-1809
    • Kaiser Permanente-Oakland Oakland, California, United States, 94611
    • Children's Hospital of Orange County Orange, California, United States, 92868
    • Lucile Packard Children's Hospital Stanford University Palo Alto, California, United States, 94304
    • Sutter Medical Center Sacramento Sacramento, California, United States, 95816
    • University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817
    • Rady Children's Hospital - San Diego San Diego, California, United States, 92123
    • Naval Medical Center -San Diego San Diego, California, United States, 92134
    • UCSF Medical Center-Mission Bay San Francisco, California, United States, 94158
    • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance, California, United States, 90502
  • United States, Colorado
    • Children's Hospital Colorado Aurora, Colorado, United States, 80045
    • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center Denver, Colorado, United States, 80218
  • United States, Connecticut
    • Connecticut Children's Medical Center Hartford, Connecticut, United States, 06106
    • Yale University New Haven, Connecticut, United States, 06520
  • United States, Delaware
    • Alfred I duPont Hospital for Children Wilmington, Delaware, United States, 19803
  • United States, District of Columbia
    • MedStar Georgetown University Hospital Washington, District of Columbia, United States, 20007
    • Children's National Medical Center Washington, District of Columbia, United States, 20010
  • United States, Florida
    • Broward Health Medical Center Fort Lauderdale, Florida, United States, 33316
    • Golisano Children's Hospital of Southwest Florida Fort Myers, Florida, United States, 33908
    • University of Florida Health Science Center - Gainesville Gainesville, Florida, United States, 32610
    • Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood, Florida, United States, 33021
    • Nemours Children's Clinic-Jacksonville Jacksonville, Florida, United States, 32207
    • University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida, United States, 33136
    • Nicklaus Children's Hospital Miami, Florida, United States, 33155
    • Miami Cancer Institute Miami, Florida, United States, 33176
    • AdventHealth Orlando Orlando, Florida, United States, 32803
    • Arnold Palmer Hospital for Children Orlando, Florida, United States, 32806
    • Nemours Children's Hospital Orlando, Florida, United States, 32827
    • Nemours Children's Clinic - Pensacola Pensacola, Florida, United States, 32504
    • Sacred Heart Hospital Pensacola, Florida, United States, 32504
    • Johns Hopkins All Children's Hospital Saint Petersburg, Florida, United States, 33701
    • Tampa General Hospital Tampa, Florida, United States, 33606
    • Saint Joseph's Hospital/Children's Hospital-Tampa Tampa, Florida, United States, 33607
    • Saint Mary's Hospital West Palm Beach, Florida, United States, 33407
  • United States, Georgia
    • Children's Healthcare of Atlanta - Egleston Atlanta, Georgia, United States, 30322
    • Augusta University Medical Center Augusta, Georgia, United States, 30912
    • Memorial Health University Medical Center Savannah, Georgia, United States, 31404
  • United States, Hawaii
    • Kapiolani Medical Center for Women and Children Honolulu, Hawaii, United States, 96826
    • Tripler Army Medical Center Honolulu, Hawaii, United States, 96859
  • United States, Idaho
    • Saint Luke's Mountain States Tumor Institute Boise, Idaho, United States, 83712
  • United States, Illinois
    • Lurie Children's Hospital-Chicago Chicago, Illinois, United States, 60611
    • University of Illinois Chicago, Illinois, United States, 60612
    • University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637
    • Loyola University Medical Center Maywood, Illinois, United States, 60153
    • Advocate Children's Hospital-Oak Lawn Oak Lawn, Illinois, United States, 60453
    • Advocate Children's Hospital-Park Ridge Park Ridge, Illinois, United States, 60068
    • Saint Jude Midwest Affiliate Peoria, Illinois, United States, 61637
    • Southern Illinois University School of Medicine Springfield, Illinois, United States, 62702
  • United States, Indiana
    • Riley Hospital for Children Indianapolis, Indiana, United States, 46202
    • Saint Vincent Hospital and Health Care Center Indianapolis, Indiana, United States, 46260
  • United States, Iowa
    • Blank Children's Hospital Des Moines, Iowa, United States, 50309
    • University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa, United States, 52242
  • United States, Kentucky
    • University of Kentucky/Markey Cancer Center Lexington, Kentucky, United States, 40536
    • Norton Children's Hospital Louisville, Kentucky, United States, 40202
  • United States, Louisiana
    • Children's Hospital New Orleans New Orleans, Louisiana, United States, 70118
    • Ochsner Medical Center Jefferson New Orleans, Louisiana, United States, 70121
  • United States, Maine
    • Eastern Maine Medical Center Bangor, Maine, United States, 04401
    • Maine Children's Cancer Program Scarborough, Maine, United States, 04074
  • United States, Maryland
    • Sinai Hospital of Baltimore Baltimore, Maryland, United States, 21215
    • Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287
    • Walter Reed National Military Medical Center Bethesda, Maryland, United States, 20889-5600
  • United States, Massachusetts
    • Floating Hospital for Children at Tufts Medical Center Boston, Massachusetts, United States, 02111
    • Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114
    • Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215
    • Baystate Medical Center Springfield, Massachusetts, United States, 01199
    • UMass Memorial Medical Center - University Campus Worcester, Massachusetts, United States, 01655
  • United States, Michigan
    • C S Mott Children's Hospital Ann Arbor, Michigan, United States, 48109
    • Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201
    • Ascension Saint John Hospital Detroit, Michigan, United States, 48236
    • Michigan State University Clinical Center East Lansing, Michigan, United States, 48824-7016
    • Hurley Medical Center Flint, Michigan, United States, 48503
    • Helen DeVos Children's Hospital at Spectrum Health Grand Rapids, Michigan, United States, 49503
    • Spectrum Health at Butterworth Campus Grand Rapids, Michigan, United States, 49503
    • Bronson Methodist Hospital Kalamazoo, Michigan, United States, 49007
    • West Michigan Cancer Center Kalamazoo, Michigan, United States, 49007
    • Beaumont Children's Hospital-Royal Oak Royal Oak, Michigan, United States, 48073
  • United States, Minnesota
    • Children's Hospitals and Clinics of Minnesota - Minneapolis Minneapolis, Minnesota, United States, 55404
    • University of Minnesota/Masonic Cancer Center Minneapolis, Minnesota, United States, 55455
    • Mayo Clinic Rochester, Minnesota, United States, 55905
  • United States, Mississippi
    • University of Mississippi Medical Center Jackson, Mississippi, United States, 39216
  • United States, Missouri
    • Columbia Regional Columbia, Missouri, United States, 65201
    • Children's Mercy Hospitals and Clinics Kansas City, Missouri, United States, 64108
    • Cardinal Glennon Children's Medical Center Saint Louis, Missouri, United States, 63104
    • Washington University School of Medicine Saint Louis, Missouri, United States, 63110
    • Mercy Hospital Saint Louis Saint Louis, Missouri, United States, 63141
  • United States, Nebraska
    • Children's Hospital and Medical Center of Omaha Omaha, Nebraska, United States, 68114
    • University of Nebraska Medical Center Omaha, Nebraska, United States, 68198
  • United States, Nevada
    • University Medical Center of Southern Nevada Las Vegas, Nevada, United States, 89102
    • Sunrise Hospital and Medical Center Las Vegas, Nevada, United States, 89109
    • Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada, United States, 89135
    • Summerlin Hospital Medical Center Las Vegas, Nevada, United States, 89144
  • United States, New Hampshire
    • Dartmouth Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756
  • United States, New Jersey
    • Hackensack University Medical Center Hackensack, New Jersey, United States, 07601
    • Morristown Medical Center Morristown, New Jersey, United States, 07960
    • Saint Peter's University Hospital New Brunswick, New Jersey, United States, 08901
    • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital New Brunswick, New Jersey, United States, 08903
    • Newark Beth Israel Medical Center Newark, New Jersey, United States, 07112
    • Saint Joseph's Regional Medical Center Paterson, New Jersey, United States, 07503
  • United States, New Mexico
    • University of New Mexico Cancer Center Albuquerque, New Mexico, United States, 87102
  • United States, New York
    • Albany Medical Center Albany, New York, United States, 12208
    • Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467
    • Roswell Park Cancer Institute Buffalo, New York, United States, 14263
    • NYU Winthrop Hospital Mineola, New York, United States, 11501
    • The Steven and Alexandra Cohen Children's Medical Center of New York New Hyde Park, New York, United States, 11040
    • Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York, United States, 10016
    • Mount Sinai Hospital New York, New York, United States, 10029
    • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York, New York, United States, 10032
    • University of Rochester Rochester, New York, United States, 14642
    • State University of New York Upstate Medical University Syracuse, New York, United States, 13210
    • New York Medical College Valhalla, New York, United States, 10595
  • United States, North Carolina
    • Mission Hospital Asheville, North Carolina, United States, 28801
    • UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599
    • Carolinas Medical Center/Levine Cancer Institute Charlotte, North Carolina, United States, 28203
    • Novant Health Presbyterian Medical Center Charlotte, North Carolina, United States, 28204
    • Duke University Medical Center Durham, North Carolina, United States, 27710
    • East Carolina University Greenville, North Carolina, United States, 27834
    • Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157
  • United States, North Dakota
    • Sanford Broadway Medical Center Fargo, North Dakota, United States, 58122
  • United States, Ohio
    • Children's Hospital Medical Center of Akron Akron, Ohio, United States, 44308
    • Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229
    • Rainbow Babies and Childrens Hospital Cleveland, Ohio, United States, 44106
    • Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195
    • Nationwide Children's Hospital Columbus, Ohio, United States, 43205
    • Dayton Children's Hospital Dayton, Ohio, United States, 45404
    • The Toledo Hospital/Toledo Children's Hospital Toledo, Ohio, United States, 43606
  • United States, Oklahoma
    • University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, United States, 73104
  • United States, Oregon
    • Legacy Emanuel Children's Hospital Portland, Oregon, United States, 97227
    • Oregon Health and Science University Portland, Oregon, United States, 97239
  • United States, Pennsylvania
    • Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania, United States, 18103
    • Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania, United States, 18017
    • Geisinger Medical Center Danville, Pennsylvania, United States, 17822
    • Penn State Children's Hospital Hershey, Pennsylvania, United States, 17033
    • Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104
    • Saint Christopher's Hospital for Children Philadelphia, Pennsylvania, United States, 19134
    • Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224
  • United States, Rhode Island
    • Rhode Island Hospital Providence, Rhode Island, United States, 02903
  • United States, South Carolina
    • Medical University of South Carolina Charleston, South Carolina, United States, 29425
    • Prisma Health Richland Hospital Columbia, South Carolina, United States, 29203
    • BI-LO Charities Children's Cancer Center Greenville, South Carolina, United States, 29605
  • United States, South Dakota
    • Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota, United States, 57117-5134
  • United States, Tennessee
    • T C Thompson Children's Hospital Chattanooga, Tennessee, United States, 37403
    • East Tennessee Childrens Hospital Knoxville, Tennessee, United States, 37916
    • St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105
    • The Children's Hospital at TriStar Centennial Nashville, Tennessee, United States, 37203
    • Vanderbilt University/Ingram Cancer Center Nashville, Tennessee, United States, 37232
  • United States, Texas
    • Dell Children's Medical Center of Central Texas Austin, Texas, United States, 78723
    • Driscoll Children's Hospital Corpus Christi, Texas, United States, 78411
    • Medical City Dallas Hospital Dallas, Texas, United States, 75230
    • UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas, United States, 75390
    • El Paso Children's Hospital El Paso, Texas, United States, 79905
    • Cook Children's Medical Center Fort Worth, Texas, United States, 76104
    • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston, Texas, United States, 77030
    • Children's Hospital of San Antonio San Antonio, Texas, United States, 78207
    • Methodist Children's Hospital of South Texas San Antonio, Texas, United States, 78229
    • University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229
    • Scott and White Memorial Hospital Temple, Texas, United States, 76508
  • United States, Utah
    • Primary Children's Hospital Salt Lake City, Utah, United States, 84113
  • United States, Vermont
    • University of Vermont and State Agricultural College Burlington, Vermont, United States, 05405
  • United States, Virginia
    • University of Virginia Cancer Center Charlottesville, Virginia, United States, 22908
    • Inova Fairfax Hospital Falls Church, Virginia, United States, 22042
    • Children's Hospital of The King's Daughters Norfolk, Virginia, United States, 23507
    • Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298
    • Carilion Clinic Children's Hospital Roanoke, Virginia, United States, 24014
  • United States, Washington
    • Seattle Children's Hospital Seattle, Washington, United States, 98105
    • Providence Sacred Heart Medical Center and Children's Hospital Spokane, Washington, United States, 99204
    • Mary Bridge Children's Hospital and Health Center Tacoma, Washington, United States, 98405
    • Madigan Army Medical Center Tacoma, Washington, United States, 98431
  • United States, West Virginia
    • West Virginia University Charleston Division Charleston, West Virginia, United States, 25304
    • West Virginia University Healthcare Morgantown, West Virginia, United States, 26506
  • United States, Wisconsin
    • University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792
    • Marshfield Medical Center-Marshfield Marshfield, Wisconsin, United States, 54449
    • Children's Hospital of Wisconsin Milwaukee, Wisconsin, United States, 53226
  • Australia, New South Wales
    • John Hunter Children's Hospital Hunter Regional Mail Centre, New South Wales, Australia, 2310
    • Sydney Children's Hospital Randwick, New South Wales, Australia, 2031
    • The Children's Hospital at Westmead Westmead, New South Wales, Australia, 2145
  • Australia, Queensland
    • Queensland Children's Hospital South Brisbane, Queensland, Australia, 4101
  • Australia, South Australia
    • Women's and Children's Hospital-Adelaide North Adelaide, South Australia, Australia, 5006
  • Australia, Western Australia
    • Princess Margaret Hospital for Children Perth, Western Australia, Australia, 6008
    • Perth Children's Hospital Perth, Western Australia, Australia, 6009
  • Canada, Alberta
    • Alberta Children's Hospital Calgary, Alberta, Canada, T3B 6A8
    • University of Alberta Hospital Edmonton, Alberta, Canada, T6G 2B7
  • Canada, British Columbia
    • British Columbia Children's Hospital Vancouver, British Columbia, Canada, V6H 3V4
  • Canada, Manitoba
    • CancerCare Manitoba Winnipeg, Manitoba, Canada, R3E 0V9
  • Canada, Newfoundland and Labrador
    • Janeway Child Health Centre Saint John's, Newfoundland and Labrador, Canada, A1B 3V6
  • Canada, Nova Scotia
    • IWK Health Centre Halifax, Nova Scotia, Canada, B3K 6R8
  • Canada, Ontario
    • McMaster Children's Hospital at Hamilton Health Sciences Hamilton, Ontario, Canada, L8N 3Z5
    • Kingston Health Sciences Centre Kingston, Ontario, Canada, K7L 2V7
    • Children's Hospital London, Ontario, Canada, N6A 5W9
    • Children's Hospital of Eastern Ontario Ottawa, Ontario, Canada, K1H 8L1
    • Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8
  • Canada, Quebec
    • The Montreal Children's Hospital of the MUHC Montreal, Quebec, Canada, H3H 1P3
    • Centre Hospitalier Universitaire Sainte-Justine Montreal, Quebec, Canada, H3T 1C5
  • Canada, Saskatchewan
    • Saskatoon Cancer Centre Saskatoon, Saskatchewan, Canada, S7N 4H4
  • Canada,
    • Centre Hospitalier Universitaire de Quebec Quebec, , Canada, G1V 4G2
  • New Zealand, Auckland
    • Starship Children's Hospital Grafton, Auckland, New Zealand, 1145
  • New Zealand,
    • Christchurch Hospital Christchurch, , New Zealand, 8011
  • Puerto Rico,
    • San Jorge Children's Hospital San Juan, , Puerto Rico, 00912
    • University Pediatric Hospital San Juan, , Puerto Rico, 00926
  • Saudi Arabia,
    • King Faisal Specialist Hospital and Research Centre Riyadh, , Saudi Arabia, 11211

Sponsors and Collaborators

Children's Oncology Group

National Cancer Institute (NCI)

More Information

No publications provided

Responsible Party: Sponsor
ClinicalTrials.gov Identifier: NCT02176967
Other Study ID Numbers: NCI-2014-00677
Study First Received:
Last Updated:
Health Authority:

Additional relevant MeSH terms:

Neuroblastoma

Ganglioneuroblastoma

Cyclophosphamide

Carboplatin

Doxorubicin

Liposomal doxorubicin

Etoposide

Etoposide phosphate

Next Steps


If you are interested in this protocol or in other treatment options at Massachusetts General Hospital, please Request a Consultation.







ClinicalTrials.gov processed this data on April 09, 2020