Clinical Trial - NCT02003222

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

Recruiting

Sponsor: National Cancer Institute (NCI)

Collaborators: Canadian Cancer Trials Group

Information provided by (Responsible party): Sponsor

ClinicalTrials.gov Identifier: NCT02003222

Protocol Info

Short Description: E1910: Phase III of Blinatumomab for Newly Diagnosed BCR-ABL-Negative B Lineage ALL in Adults
Long Description: E1910: A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia in Adults
MGH Status: Open
Sponsor: Coop/ECOG
Disease Program: Leukemia

Next Steps


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Purpose

This randomized phase III trial studies combination chemotherapy with blinatumomab to see how well it works compared to induction chemotherapy alone in treating patients with newly diagnosed breakpoint cluster region (BCR)-c-abl oncogene 1, non-receptor tyrosine kinase (ABL)-negative B lineage acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as blinatumomab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread It is not yet known whether combination chemotherapy is more effective with or without blinatumomab in treating newly diagnosed acute lymphoblastic leukemia.
Condition Title Intervention Phase
Acute Lymphoblastic Leukemia B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative BCR/ABL1 Fusion Protein Negative Untreated Adult Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation Blinatumomab Cyclophosphamide Cytarabine Daunorubicin Hydrochloride Dexamethasone Etoposide Laboratory Biomarker Analysis Mercaptopurine Methotrexate Pegaspargase Prednisone Rituximab Vincristine Sulfate Phase 3
Study Type Interventional
Official Title A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia in Adults

Primary Outcome Measures

Overall survival [Time Frame: Time between randomization and death from any cause, assessed up to 10 years] [Designated as safety issue: ]


Secondary Outcome Measures

Relapse-free survival [Time Frame: Time from randomization to relapse or death without documentation of relapse, assessed up to 10 years] [Designated as safety issue: ]

Minimal residual disease status [Time Frame: Up to 32 weeks] [Designated as safety issue: ]

Incidence of adverse events, per the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 [Time Frame: Up to 10 years] [Designated as safety issue: ]

Estimated Enrollment: 488
Study Start Date: December 2013
Estimated Study Completion Date:
Estimated Primary Completion Date: June 2021
Arms Assigned Interventions

Experimental:Arm I (blinatumomab, chemotherapy)

See Detailed Description
Drug:Vincristine Sulfate
Given IV

Active Comparator:Arm II (chemotherapy)

See Detailed Description

Eligibility

Ages Eligible for Study: 70 Years-70 Years

Genders Eligible for Study: All

Accepts Healthly Volunteers: Accepts Healthy Volunteers

Inclusion Criteria:

  • PRE-REGISTRATION
  • Diagnostic bone marrow and peripheral blood specimens must be submitted for immunophenotyping and selected molecular testing, and the establishment of BCR/ABL status; testing will be performed by the Eastern Cooperative Oncology Group (ECOG)-American College of Radiation Imaging Network (ACRIN) Leukemia Translational Research Laboratory (LTRL) and reported to the institution
  • NOTE: IT IS ESSENTIAL THAT A SAMPLE CONTAINING SUFFICIENT BLAST CELLS BE SUBMITTED TO THE ECOG-ACRIN LTRL AT BASELINE SO THAT SUBSEQUENT BONE MARROW ASSESSMENTS OF MRD CAN BE DONE; IN ADDITION TO ALLOWING THE LTRL TO CONFIRM ELIGIBILITY BASED ON BLAST CELL IMMUNOPHENOTYPE AND BCR/ABL STATUS, IT IS ALSO IMPERATIVE THAT AN ADEQUATE NUMBER OF BLASTS BE BANKED FOR ANALYSIS BY DRS MULLIGHAN/WILLMAN. WITHOUT ADEQUATE BASELINE SAMPLES, PATIENTS WILL NOT BE ABLE TO BE TREATED AND RANDOMIZED ON THIS PROTOCOL; IF A BONE MARROW ASPIRATE IS NOT AVAILABLE FOR LTRL SUBMISSION AT BASELINE, IT IS IMPERATIVE THAT DR PAIETTA FROM THE LTRL IS CALLED TO DISCUSS THE PERIPHERAL BLOOD WBC AND BLAST COUNT BEFORE BLOOD ONLY IS SUBMITTED
  • NOTE: Hydroxyurea can be given for up to 5 days prior to initiation of protocol therapy for control of leukocyte count and/or other symptoms or signs; corticosteroids can be given after pre-registration to the protocol and submission of baseline marrow and blood samples for control of leukocyte count and/or other symptoms or signs prior to initiation of protocol therapy if needed; if corticosteroids are given prior to pre-registration, contact the study chair as the patient may still be eligible to participate
  • INDUCTION ELIGIBILITY CRITERIA-STEP 1
  • New diagnosis of B lineage ALL must be made upon bone marrow or peripheral blood immunophenotyping; cases with myeloid antigen expression, but unequivocal lymphoid immunophenotype, are eligible
  • Mature B ALL (Burkitt's-like leukemia) is excluded from enrollment in this trial; pre-study bone marrow biopsy and aspirate must be completed =< 1 week prior to registration
  • Negativity for the Philadelphia chromosome must be established by conventional cytogenetics, fluorescence in situ hybridization (FISH) and/or polymerase chain reaction (PCR); patients who are negative for the Philadelphia chromosome by conventional cytogenetics must have FISH or PCR performed for BCR/ABL to exclude occult translocations
  • Cytogenetic analysis must be performed from diagnostic bone marrow (preferred) or if adequate number of circulating blasts from peripheral blood; FISH testing for common B-lineage ALL abnormalities including t(9;22) (BCR/ABL1), t(12;21) (ETS-variant gene 6 [ETV6]/runt-related transcription factor 1 [RUNX1]), t(1;19) (pre-B-cell leukemia homeobox 1 [PBX1]/transcription factor 3 [TCF3]), +4,+10,+17, (centromeric [Cen]4/Cen10/Cen17), t(11q23;var), (myeloid/lymphoid or mixed lineage leukemia [MLL]), deletion (del)(9p) (cyclin-dependent kinase inhibitor 2A [CDKN2A]/Cen9), and t(14;var) (immunoglobulin heavy chain [IGH] is encouraged); if there are few or no circulating blasts and an adequate marrow sample cannot be obtained for cytogenetic analysis, the patient may still enroll on the trial
  • Patient must not have a concurrent active malignancy for which they are receiving treatment
  • Serum direct bilirubin < 2 mg/dl or serum total bilirubin =< 3 (obtained =< 48 hours prior to registration); NOTE: the above stipulation for normal hepatic function does not apply if liver dysfunction is due to leukemia infiltration
  • Serum creatinine < 2 mg/dl (obtained =< 48 hours prior to registration); NOTE: the above stipulation for normal hepatic function does not apply if liver dysfunction is due to leukemia infiltration
  • Patient should be human leukocyte antigen (HLA) typed (A, B, C, DR and DQ) during induction therapy phase or a written explanation for not undergoing HLA typing on the flow sheet
  • Patient must not have intercurrent organ damage or medical problems that will jeopardize the outcome of therapy (i.e., psychiatric disorder, drug abuse, pregnancy)
  • Patients with known human immunodeficiency virus (HIV) infection are eligible if they meet all of the following criteria:
  • No history of acquired immune deficiency syndrome (AIDS)-related complications other than a history of low CD4+ T-cell count (< 200/mm^3) prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to leukemia and should not be used as an exclusion criterion if low
  • Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the leukemia
  • Patient must have serum HIV viral load of < 200 copies/mm^3
  • Patient must be on combination antiretroviral therapy with minimal pharmacokinetic interactions with study therapy and minimal overlapping clinical toxicity with protocol therapy
  • Patient must not be receiving protease inhibitors or once daily formulations containing cobicistat, stavudine, or on regimens containing stavudine or zidovudine
  • It is recommended to utilize a regimen of the integrase inhibitor, dolutegravir, combined with either disoproxil fumarate/emtricitabine or dolutegravir combined with tenofovir alafenamide/emtricitabine
  • Patient must not have an antecedent hematologic disorder
  • Patient must have no history of recent myocardial infarction (within three months), uncontrolled congestive heart failure, or uncontrolled cardiac arrhythmia
  • Patient must not have a history or presence of clinically relevant central nervous system (CNS) pathology such as epilepsy, seizure, paresis, aphasia, stroke, severe brain injuries, dementia; Parkinson's disease, cerebellar disease, organic brain syndrome, psychosis, or other significant CNS abnormalities
  • Patient must have a normal cardiac ejection fraction by pretreatment multigated acquisition scan (MUGA) or echocardiogram within 4 weeks prior to registration (resting ejection fraction >= 40% or >= 5% increase with exercise), shortening fraction by echocardiogram >= 24%, or to within the normal range of values for the institution
  • Patient must not have an active uncontrolled infection
  • Women must not be pregnant or breast-feeding and must not become pregnant or breastfeed during protocol therapy and for at least 3 months after protocol therapy; woman of childbearing potential must abstain from sexual activity or be willing to use 2 highly effective forms of contraception throughout protocol therapy and for at least an additional 3 months after the last dose of protocol-specified therapy; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: has not undergone a hysterectomy or bilateral oophorectomy; or has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Men who have a female partner of childbearing potential must be willing to use 2 highly effective forms of contraception throughout protocol therapy and for at least an additional 3 months after the last dose of protocol-specified therapy; men who have a pregnant partner must be willing to use a condom during sexual activity throughout protocol therapy and for 3 months after the last dose of protocol-specified therapy
  • ECOG performance score 0-3
  • Patient must have given written informed consent
  • POST-INDUCTION THERAPY ELIGIBILITY CRITERIA (PRIOR TO INTENSIFICATION-STEP 2)
  • ECOG performance status 0-2
  • Patients must have achieved a CR or CRi
  • Patients who have achieved a CR or CRi must have maintained peripheral blood evidence of a CR or CRi
  • Patient must be CNS (cerebrospinal fluid [CSF]) negative for leukemia
  • Patients must have resolved any serious infectious complications related to induction
  • Any significant medical complications related to induction must have resolved
  • Serum creatinine =< 2.0 mg/dl (obtained =< 48 hours prior to registration)
  • Serum direct bilirubin < 2 mg/dL or serum total bilirubin =< 3 (obtained =< 48 hours prior to registration)
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN) (obtained =< 48 hours prior to registration)
  • RANDOMIZATION TO BLINATUMOMAB OR NO BLINATUMOMAB-STEP 3
  • Patients must have an ECOG performance status of 0-2
  • Patients must have maintained peripheral blood evidence of a remission and must have a CR or CRi, confirmed on restaging bone marrow (BM) aspirate and biopsy
  • Patients must have resolved any serious infectious complications related to therapy
  • Any significant medical complications related to therapy must have resolved
  • Direct or total bilirubin < 1.5 x ULN (unless related to Gilbert's or Meulengracht's syndrome); the values must be obtained within 48 hours prior to randomization
  • Serum creatinine < 1.5 x ULN; the values must be obtained within 48 hours prior to randomization
  • Bone marrow aspirates must be submitted for centralized minimal residual disease (MRD) assessment performed by the ECOG-ACRIN Leukemia Translational Research Laboratory
  • MRD results will be reported to the submitting institution
  • NOTE: FOR MRD ASSESSMENTS, AN ASPIRATE FROM A SEPARATE BONE MARROW ASPIRATION SITE MUST BE SUBMITTED (THE NEEDLE CAN BE RE-DIRECTED THROUGH THE SAME SKIN PUNCTURE SITE); ONLY SUBMIT ASPIRATES FROM THE FIRST PULL OF AN ASPIRATION SITE FOR MRD TESTING; DO NOT SUBMIT SAMPLES FROM THE SECOND OR THIRD PULL OF THE SAME ASPIRATION SITE
  • In B-lineage ALL, MRD levels in peripheral blood or from a dilute marrow aspiration can be 300% lower, on average, than those in bone marrow at a given time point; submitting a first pull from a separate aspiration site will ensure that MRD determinations used in randomization and trial interpretation are accurate
  • NOTE: failure to submit bone marrow aspirates will result in a major violation at the time of an audit
  • CRITERIA FOR ALLOGENEIC TRANSPLANTATION
  • A suitable donor must be identified; there are no restrictions on donor type and can include a matched sibling, a matched or mismatched unrelated donor, a family haplotype matched donor or a cord blood donor (single or double)
  • Patients should meet the eligibility criteria for RANDOMIZATION TO BLINATUMOMAB OR NO BLINATUMOMAB-STEP 3
  • Patients must be considered reliable enough to comply with the medication regimen and follow-up, and have social support necessary to allow this compliance
  • CRITERIA FOR MAINTENANCE THERAPY-STEP 4: Patients must have an ECOG performance status of 0-3
  • CRITERIA FOR MAINTENANCE THERAPY-STEP 4: Patients must have maintained peripheral blood evidence of a remission and must have a CR or CRi, confirmed on restaging BM aspirate and biopsy
  • CRITERIA FOR MAINTENANCE THERAPY-STEP 4: Patients must have resolved any serious infectious complications related to therapy
  • CRITERIA FOR MAINTENANCE THERAPY-STEP 4: Any significant medical complications related to therapy must have resolved

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT02003222

Locations

  • United States, Alabama
    • University of Alabama at Birmingham Cancer Center Birmingham, Alabama, United States, 35233
  • United States, Alaska
    • Anchorage Associates in Radiation Medicine Anchorage, Alaska, United States, 98508
    • Anchorage Radiation Therapy Center Anchorage, Alaska, United States, 99504
    • Alaska Breast Care and Surgery LLC Anchorage, Alaska, United States, 99508
    • Alaska Oncology and Hematology LLC Anchorage, Alaska, United States, 99508
    • Alaska Regional Hospital Anchorage, Alaska, United States, 99508
    • Alaska Women's Cancer Care Anchorage, Alaska, United States, 99508
    • Anchorage Oncology Centre Anchorage, Alaska, United States, 99508
    • Katmai Oncology Group Anchorage, Alaska, United States, 99508
    • Providence Alaska Medical Center Anchorage, Alaska, United States, 99508
  • United States, Arizona
    • Banner University Medical Center - Tucson Tucson, Arizona, United States, 85719
    • University of Arizona Cancer Center-North Campus Tucson, Arizona, United States, 85719
  • United States, Arkansas
    • Mercy Hospital Fort Smith Fort Smith, Arkansas, United States, 72903
    • University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205
  • United States, California
    • PCR Oncology Arroyo Grande, California, United States, 93420
    • Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank, California, United States, 91505
    • Community Cancer Institute Clovis, California, United States, 93611
    • University Oncology Associates Clovis, California, United States, 93611
    • UC San Diego Moores Cancer Center La Jolla, California, United States, 92093
    • UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California, United States, 92868
    • Stanford Cancer Institute Palo Alto Palo Alto, California, United States, 94304
  • United States, Colorado
    • Rocky Mountain Cancer Centers-Aurora Aurora, Colorado, United States, 80012
    • The Medical Center of Aurora Aurora, Colorado, United States, 80012
    • Boulder Community Hospital Boulder, Colorado, United States, 80301
    • Rocky Mountain Cancer Centers-Boulder Boulder, Colorado, United States, 80304
    • National Jewish Health-Main Campus Denver, Colorado, United States, 80206
    • The Women's Imaging Center Denver, Colorado, United States, 80209
    • Colorado Blood Cancer Institute Denver, Colorado, United States, 80218
    • Presbyterian - Saint Lukes Medical Center - Health One Denver, Colorado, United States, 80218
    • Rocky Mountain Cancer Centers-Midtown Denver, Colorado, United States, 80218
    • SCL Health Saint Joseph Hospital Denver, Colorado, United States, 80218
    • Rocky Mountain Cancer Centers-Rose Denver, Colorado, United States, 80220
    • Rose Medical Center Denver, Colorado, United States, 80220
    • Western Surgical Care Denver, Colorado, United States, 80220
    • Comprehensive Cancer Care and Research Institute of Colorado LLC Englewood, Colorado, United States, 80113
    • Swedish Medical Center Englewood, Colorado, United States, 80113
    • National Jewish Health-Western Hematology Oncology Golden, Colorado, United States, 80401
    • Saint Mary's Hospital and Regional Medical Center Grand Junction, Colorado, United States, 81501
    • Grand Valley Oncology Grand Junction, Colorado, United States, 81505
    • North Colorado Medical Center Greeley, Colorado, United States, 80631
    • Good Samaritan Medical Center Lafayette, Colorado, United States, 80026
    • Rocky Mountain Cancer Centers-Littleton Littleton, Colorado, United States, 80120
    • Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado, United States, 80124
    • Sky Ridge Medical Center Lone Tree, Colorado, United States, 80124
    • McKee Medical Center Loveland, Colorado, United States, 80539
    • National Jewish Health-Northern Hematology Oncology Thornton, Colorado, United States, 80260
    • SCL Health Lutheran Medical Center Wheat Ridge, Colorado, United States, 80033
  • United States, Connecticut
    • Smilow Cancer Hospital Care Center at Saint Francis Hartford, Connecticut, United States, 06105
    • Yale University New Haven, Connecticut, United States, 06520
    • Smilow Cancer Hospital-Torrington Care Center Torrington, Connecticut, United States, 06790
  • United States, District of Columbia
    • Sibley Memorial Hospital Washington, District of Columbia, United States, 20016
  • United States, Florida
    • UM Sylvester Comprehensive Cancer Center at Coral Springs Coral Springs, Florida, United States, 33065
    • UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach, Florida, United States, 33442
    • UM Sylvester Comprehensive Cancer Center at Hollywood Hollywood, Florida, United States, 33021
    • Baptist MD Anderson Cancer Center Jacksonville, Florida, United States, 32207
    • University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida, United States, 33136
    • UM Sylvester Comprehensive Cancer Center at Kendall Miami, Florida, United States, 33176
    • UM Sylvester Comprehensive Cancer Center at Plantation Plantation, Florida, United States, 33324
    • Cleveland Clinic-Weston Weston, Florida, United States, 33331
  • United States, Georgia
    • Emory University Hospital/Winship Cancer Institute Atlanta, Georgia, United States, 30322
    • Northside Hospital Atlanta, Georgia, United States, 30342
  • United States, Idaho
    • Saint Alphonsus Cancer Care Center-Boise Boise, Idaho, United States, 83706
    • Saint Luke's Mountain States Tumor Institute Boise, Idaho, United States, 83712
    • Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho, United States, 83605
    • Kootenai Medical Center Coeur d'Alene, Idaho, United States, 83814
    • Walter Knox Memorial Hospital Emmett, Idaho, United States, 83617
    • Saint Luke's Mountain States Tumor Institute - Fruitland Fruitland, Idaho, United States, 83619
    • Idaho Urologic Institute-Meridian Meridian, Idaho, United States, 83642
    • Saint Luke's Mountain States Tumor Institute - Meridian Meridian, Idaho, United States, 83642
    • Saint Alphonsus Medical Center-Nampa Nampa, Idaho, United States, 83686
    • Saint Luke's Mountain States Tumor Institute - Nampa Nampa, Idaho, United States, 83686
    • Kootenai Cancer Center Post Falls, Idaho, United States, 83854
    • Kootenai Cancer Clinic Sandpoint, Idaho, United States, 83864
    • Saint Luke's Mountain States Tumor Institute-Twin Falls Twin Falls, Idaho, United States, 83301
  • United States, Illinois
    • Saint Joseph Medical Center Bloomington, Illinois, United States, 61701
    • Illinois CancerCare-Bloomington Bloomington, Illinois, United States, 61704
    • Illinois CancerCare-Canton Canton, Illinois, United States, 61520
    • Memorial Hospital of Carbondale Carbondale, Illinois, United States, 62902
    • SIH Cancer Institute Carterville, Illinois, United States, 62918
    • Illinois CancerCare-Carthage Carthage, Illinois, United States, 62321
    • Centralia Oncology Clinic Centralia, Illinois, United States, 62801
    • Mount Sinai Hospital Medical Center Chicago, Illinois, United States, 60608
    • Northwestern University Chicago, Illinois, United States, 60611
    • University of Illinois Chicago, Illinois, United States, 60612
    • University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637
    • Cancer Care Specialists of Illinois - Decatur Decatur, Illinois, United States, 62526
    • Decatur Memorial Hospital Decatur, Illinois, United States, 62526
    • Crossroads Cancer Center Effingham, Illinois, United States, 62401
    • Illinois CancerCare-Eureka Eureka, Illinois, United States, 61530
    • NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201
    • Illinois CancerCare-Galesburg Galesburg, Illinois, United States, 61401
    • Western Illinois Cancer Treatment Center Galesburg, Illinois, United States, 61401
    • NorthShore University HealthSystem-Glenbrook Hospital Glenview, Illinois, United States, 60026
    • Hematology Oncology Associates of Illinois-Highland Park Highland Park, Illinois, United States, 60035
    • NorthShore University HealthSystem-Highland Park Hospital Highland Park, Illinois, United States, 60035
    • Presence Saint Mary's Hospital Kankakee, Illinois, United States, 60901
    • Illinois CancerCare-Kewanee Clinic Kewanee, Illinois, United States, 61443
    • NorthShore Hematology Oncology-Libertyville Libertyville, Illinois, United States, 60048
    • Illinois CancerCare-Macomb Macomb, Illinois, United States, 61455
    • Loyola University Medical Center Maywood, Illinois, United States, 60153
    • Good Samaritan Regional Health Center Mount Vernon, Illinois, United States, 62864
    • Illinois Cancer Specialists-Niles Niles, Illinois, United States, 60714
    • Illinois CancerCare-Ottawa Clinic Ottawa, Illinois, United States, 61350
    • Radiation Oncology of Northern Illinois Ottawa, Illinois, United States, 61350
    • Illinois CancerCare-Pekin Pekin, Illinois, United States, 61554
    • OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin, Illinois, United States, 61554
    • Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615
    • OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria, Illinois, United States, 61615
    • Methodist Medical Center of Illinois Peoria, Illinois, United States, 61636
    • OSF Saint Francis Medical Center Peoria, Illinois, United States, 61637
    • Illinois CancerCare-Peru Peru, Illinois, United States, 61354
    • Valley Radiation Oncology Peru, Illinois, United States, 61354
    • Illinois CancerCare-Princeton Princeton, Illinois, United States, 61356
    • Hematology Oncology Associates of Illinois - Skokie Skokie, Illinois, United States, 60076
    • North Shore Medical Center Skokie, Illinois, United States, 60076
    • Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62702
    • Southern Illinois University School of Medicine Springfield, Illinois, United States, 62702
    • Springfield Clinic Springfield, Illinois, United States, 62702
    • Memorial Medical Center Springfield, Illinois, United States, 62781
    • Cancer Care Specialists of Illinois-Swansea Swansea, Illinois, United States, 62226
    • Southwest Illinois Health Services LLP Swansea, Illinois, United States, 62226
  • United States, Indiana
    • Parkview Hospital Randallia Fort Wayne, Indiana, United States, 46805
    • Parkview Regional Medical Center Fort Wayne, Indiana, United States, 46845
    • Franciscan Health Indianapolis Indianapolis, Indiana, United States, 46237
    • Franciscan Health Mooresville Mooresville, Indiana, United States, 46158
    • Reid Health Richmond, Indiana, United States, 47374
  • United States, Iowa
    • Mary Greeley Medical Center Ames, Iowa, United States, 50010
    • McFarland Clinic PC - Ames Ames, Iowa, United States, 50010
    • McFarland Clinic PC-Boone Boone, Iowa, United States, 50036
    • McFarland Clinic PC-Trinity Cancer Center Fort Dodge, Iowa, United States, 50501
    • McFarland Clinic PC-Jefferson Jefferson, Iowa, United States, 50129
    • McFarland Clinic PC-Marshalltown Marshalltown, Iowa, United States, 50158
  • United States, Kansas
    • Cancer Center of Kansas - Chanute Chanute, Kansas, United States, 66720
    • Cancer Center of Kansas - Dodge City Dodge City, Kansas, United States, 67801
    • Cancer Center of Kansas - El Dorado El Dorado, Kansas, United States, 67042
    • Cancer Center of Kansas - Fort Scott Fort Scott, Kansas, United States, 66701
    • Central Care Cancer Center - Garden City Garden City, Kansas, United States, 67846
    • Central Care Cancer Center - Great Bend Great Bend, Kansas, United States, 67530
    • Cancer Center of Kansas-Independence Independence, Kansas, United States, 67301
    • University of Kansas Cancer Center Kansas City, Kansas, United States, 66160
    • Cancer Center of Kansas-Kingman Kingman, Kansas, United States, 67068
    • Lawrence Memorial Hospital Lawrence, Kansas, United States, 66044
    • Kansas Institute of Medicine Cancer and Blood Center Lenexa, Kansas, United States, 66219
    • Minimally Invasive Surgery Hospital Lenexa, Kansas, United States, 66219
    • Cancer Center of Kansas-Liberal Liberal, Kansas, United States, 67905
    • Cancer Center of Kansas-Manhattan Manhattan, Kansas, United States, 66502
    • Cancer Center of Kansas - McPherson McPherson, Kansas, United States, 67460
    • Cancer Center of Kansas - Newton Newton, Kansas, United States, 67114
    • Olathe Medical Center Olathe, Kansas, United States, 66061
    • Menorah Medical Center Overland Park, Kansas, United States, 66209
    • Saint Luke's South Hospital Overland Park, Kansas, United States, 66213
    • Cancer Center of Kansas - Parsons Parsons, Kansas, United States, 67357
    • Cancer Center of Kansas - Pratt Pratt, Kansas, United States, 67124
    • Cancer Center of Kansas - Salina Salina, Kansas, United States, 67401
    • Cancer Center of Kansas - Wellington Wellington, Kansas, United States, 67152
    • University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas, United States, 66205
    • Associates In Womens Health Wichita, Kansas, United States, 67208
    • Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas, United States, 67208
    • Cancer Center of Kansas - Wichita Wichita, Kansas, United States, 67214
    • Via Christi Regional Medical Center Wichita, Kansas, United States, 67214
    • Wesley Medical Center Wichita, Kansas, United States, 67214
    • Cancer Center of Kansas - Winfield Winfield, Kansas, United States, 67156
  • United States, Kentucky
    • Oncology Hematology Care Inc-Crestview Crestview Hills, Kentucky, United States, 41017
  • United States, Louisiana
    • Ochsner Health Center-Summa Baton Rouge, Louisiana, United States, 70809
    • Medical Center of Baton Rouge Baton Rouge, Louisiana, United States, 70816
    • Ochsner High Grove Baton Rouge, Louisiana, United States, 70836
    • University Health-Conway Monroe, Louisiana, United States, 71202
    • Ochsner Medical Center Jefferson New Orleans, Louisiana, United States, 70121
    • Louisiana State University Health Sciences Center Shreveport Shreveport, Louisiana, United States, 71103
  • United States, Maine
    • Eastern Maine Medical Center Bangor, Maine, United States, 04401
    • Lafayette Family Cancer Center-EMMC Brewer, Maine, United States, 04412
  • United States, Maryland
    • University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201
    • Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287
    • Walter Reed National Military Medical Center Bethesda, Maryland, United States, 20889-5600
  • United States, Massachusetts
    • Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114
    • Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215
    • Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215
  • United States, Michigan
    • Bixby Medical Center Adrian, Michigan, United States, 49221
    • Hickman Cancer Center Adrian, Michigan, United States, 49221
    • Saint Joseph Mercy Hospital Ann Arbor, Michigan, United States, 48106
    • Bronson Battle Creek Battle Creek, Michigan, United States, 49017
    • Henry Ford Cancer Institute-Downriver Brownstown, Michigan, United States, 48183
    • Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan, United States, 48038
    • Beaumont Hospital - Dearborn Dearborn, Michigan, United States, 48124
    • Henry Ford Medical Center-Fairlane Dearborn, Michigan, United States, 48126
    • Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201
    • Henry Ford Hospital Detroit, Michigan, United States, 48202
    • Ascension Saint John Hospital Detroit, Michigan, United States, 48236
    • Green Bay Oncology - Escanaba Escanaba, Michigan, United States, 49829
    • Weisberg Cancer Treatment Center Farmington Hills, Michigan, United States, 48334
    • Beaumont Hospital - Farmington Hills Farmington Hills, Michigan, United States, 48336
    • Genesys Hurley Cancer Institute Flint, Michigan, United States, 48503
    • Hurley Medical Center Flint, Michigan, United States, 48503
    • Helen DeVos Children's Hospital at Spectrum Health Grand Rapids, Michigan, United States, 49503
    • Mercy Health Saint Mary's Grand Rapids, Michigan, United States, 49503
    • Spectrum Health at Butterworth Campus Grand Rapids, Michigan, United States, 49503
    • William Beaumont Hospital-Grosse Point Grosse Pointe, Michigan, United States, 48230
    • Allegiance Health Jackson, Michigan, United States, 49201
    • Bronson Methodist Hospital Kalamazoo, Michigan, United States, 49007
    • West Michigan Cancer Center Kalamazoo, Michigan, United States, 49007
    • Borgess Medical Center Kalamazoo, Michigan, United States, 49048
    • Sparrow Hospital Lansing, Michigan, United States, 48912
    • Saint Mary Mercy Hospital Livonia, Michigan, United States, 48154
    • Mercy Memorial Hospital Monroe, Michigan, United States, 48162
    • Toledo Clinic Cancer Centers-Monroe Monroe, Michigan, United States, 48162
    • Mercy Health Mercy Campus Muskegon, Michigan, United States, 49444
    • Lakeland Hospital Niles Niles, Michigan, United States, 49120
    • Henry Ford Medical Center-Columbus Novi, Michigan, United States, 48377
    • Saint Joseph Mercy Oakland Pontiac, Michigan, United States, 48341
    • Huron Medical Center PC Port Huron, Michigan, United States, 48060
    • Lake Huron Medical Center Port Huron, Michigan, United States, 48060
    • Spectrum Health Reed City Hospital Reed City, Michigan, United States, 49677
    • Michigan Cancer Specialists Roseville, Michigan, United States, 48066
    • Oakland Colon and Rectal Association Royal Oak, Michigan, United States, 48067
    • Cancer Care Associates PC Royal Oak, Michigan, United States, 48073
    • Comprehensive Medical Center PLLC Royal Oak, Michigan, United States, 48073
    • Hematology Oncology Consultants PC Royal Oak, Michigan, United States, 48073
    • Oakland Medical Group Royal Oak, Michigan, United States, 48073
    • William Beaumont Hospital-Royal Oak Royal Oak, Michigan, United States, 48073
    • Ascension Saint Mary's Hospital Saginaw, Michigan, United States, 48601
    • Lakeland Medical Center Saint Joseph Saint Joseph, Michigan, United States, 49085
    • Marie Yeager Cancer Center Saint Joseph, Michigan, United States, 49085
    • Premier Hematology Oncology Care Sterling Heights, Michigan, United States, 48312
    • Mitchell Folbe MD PC Sterling Heights, Michigan, United States, 48314
    • Munson Medical Center Traverse City, Michigan, United States, 49684
    • Michigan Institute of Urology-Town Center Troy, Michigan, United States, 48084
    • Claudia BR Herke MD PC Troy, Michigan, United States, 48085
    • William Beaumont Hospital - Troy Troy, Michigan, United States, 48085
    • Hematology Oncology Consultants PC-Troy Troy, Michigan, United States, 48098
    • Saint John Macomb-Oakland Hospital Warren, Michigan, United States, 48093
    • Henry Ford West Bloomfield Hospital West Bloomfield, Michigan, United States, 48322
    • Metro Health Hospital Wyoming, Michigan, United States, 49519
  • United States, Minnesota
    • Mayo Clinic Rochester, Minnesota, United States, 55905
  • United States, Missouri
    • Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri, United States, 63011
    • Central Care Cancer Center - Bolivar Bolivar, Missouri, United States, 65613
    • Parkland Health Center-Bonne Terre Bonne Terre, Missouri, United States, 63628
    • Cox Cancer Center Branson Branson, Missouri, United States, 65616
    • Saint Francis Medical Center Cape Girardeau, Missouri, United States, 63703
    • Southeast Cancer Center Cape Girardeau, Missouri, United States, 63703
    • Siteman Cancer Center at West County Hospital Creve Coeur, Missouri, United States, 63141
    • Centerpoint Medical Center LLC Independence, Missouri, United States, 64057
    • Capital Region Southwest Campus Jefferson City, Missouri, United States, 65109
    • Freeman Health System Joplin, Missouri, United States, 64804
    • Mercy Hospital Joplin Joplin, Missouri, United States, 64804
    • Saint Luke's Hospital of Kansas City Kansas City, Missouri, United States, 64111
    • Heartland Hematology and Oncology Associates Incorporated Kansas City, Missouri, United States, 64118
    • Research Medical Center Kansas City, Missouri, United States, 64132
    • Saint Luke's East - Lee's Summit Lee's Summit, Missouri, United States, 64086
    • Liberty Radiation Oncology Center Liberty, Missouri, United States, 64068
    • Delbert Day Cancer Institute at PCRMC Rolla, Missouri, United States, 65401
    • Mercy Clinic-Rolla-Cancer and Hematology Rolla, Missouri, United States, 65401
    • Heartland Regional Medical Center Saint Joseph, Missouri, United States, 64507
    • Saint Louis Cancer and Breast Institute-South City Saint Louis, Missouri, United States, 63109
    • Washington University School of Medicine Saint Louis, Missouri, United States, 63110
    • Mercy Hospital South Saint Louis, Missouri, United States, 63128
    • Siteman Cancer Center-South County Saint Louis, Missouri, United States, 63129
    • Missouri Baptist Medical Center Saint Louis, Missouri, United States, 63131
    • Mercy Hospital Saint Louis Saint Louis, Missouri, United States, 63141
    • Siteman Cancer Center at Saint Peters Hospital Saint Peters, Missouri, United States, 63376
    • Sainte Genevieve County Memorial Hospital Sainte Genevieve, Missouri, United States, 63670
    • Mercy Hospital Springfield Springfield, Missouri, United States, 65804
    • CoxHealth South Hospital Springfield, Missouri, United States, 65807
    • Missouri Baptist Sullivan Hospital Sullivan, Missouri, United States, 63080
    • Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills, Missouri, United States, 63127
    • Mercy Hospital Washington Washington, Missouri, United States, 63090
  • United States, Montana
    • Community Hospital of Anaconda Anaconda, Montana, United States, 59711
    • Billings Clinic Cancer Center Billings, Montana, United States, 59101
    • Saint Vincent Healthcare Billings, Montana, United States, 59101
    • Saint Vincent Frontier Cancer Center Billings, Montana, United States, 59102
    • Bozeman Deaconess Hospital Bozeman, Montana, United States, 59715
    • Saint James Community Hospital and Cancer Treatment Center Butte, Montana, United States, 59701
    • Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana, United States, 59405
    • Great Falls Clinic Great Falls, Montana, United States, 59405
    • Saint Peter's Community Hospital Helena, Montana, United States, 59601
    • Kalispell Regional Medical Center Kalispell, Montana, United States, 59901
    • Saint Patrick Hospital - Community Hospital Missoula, Montana, United States, 59802
    • Community Medical Hospital Missoula, Montana, United States, 59804
  • United States, Nebraska
    • Nebraska Medicine-Bellevue Bellevue, Nebraska, United States, 68123
    • Nebraska Medicine-Village Pointe Omaha, Nebraska, United States, 68118
    • University of Nebraska Medical Center Omaha, Nebraska, United States, 68198
  • United States, Nevada
    • Carson Tahoe Regional Medical Center Carson City, Nevada, United States, 89703
    • Cancer and Blood Specialists-Henderson Henderson, Nevada, United States, 89052
    • Comprehensive Cancer Centers of Nevada - Henderson Henderson, Nevada, United States, 89052
    • Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson, Nevada, United States, 89052
    • Las Vegas Cancer Center-Henderson Henderson, Nevada, United States, 89052
    • OptumCare Cancer Care at Seven Hills Henderson, Nevada, United States, 89052
    • 21st Century Oncology-Henderson Henderson, Nevada, United States, 89074
    • Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson, Nevada, United States, 89074
    • Desert West Surgery Las Vegas, Nevada, United States, 89102
    • University Medical Center of Southern Nevada Las Vegas, Nevada, United States, 89102
    • Hope Cancer Care of Nevada Las Vegas, Nevada, United States, 89103
    • Cancer and Blood Specialists-Shadow Las Vegas, Nevada, United States, 89106
    • OptumCare Cancer Care at Oakey Las Vegas, Nevada, United States, 89106
    • Radiation Oncology Centers of Nevada Central Las Vegas, Nevada, United States, 89106
    • 21st Century Oncology Las Vegas, Nevada, United States, 89109
    • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas, Nevada, United States, 89109
    • Sunrise Hospital and Medical Center Las Vegas, Nevada, United States, 89109
    • HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas, Nevada, United States, 89113
    • Radiation Oncology Centers of Nevada Southeast Las Vegas, Nevada, United States, 89119
    • Cancer Therapy and Integrative Medicine Las Vegas, Nevada, United States, 89121
    • 21st Century Oncology-Vegas Tenaya Las Vegas, Nevada, United States, 89128
    • Ann M Wierman MD LTD Las Vegas, Nevada, United States, 89128
    • Cancer and Blood Specialists-Tenaya Las Vegas, Nevada, United States, 89128
    • Comprehensive Cancer Centers of Nevada - Northwest Las Vegas, Nevada, United States, 89128
    • HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas, Nevada, United States, 89128
    • OptumCare Cancer Care at MountainView Las Vegas, Nevada, United States, 89128
    • Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada, United States, 89135
    • Comprehensive Cancer Centers of Nevada - Town Center Las Vegas, Nevada, United States, 89144
    • Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas, Nevada, United States, 89144
    • Summerlin Hospital Medical Center Las Vegas, Nevada, United States, 89144
    • Las Vegas Cancer Center-Medical Center Las Vegas, Nevada, United States, 89148-2405
    • 21st Century Oncology-Fort Apache Las Vegas, Nevada, United States, 89148
    • Comprehensive Cancer Centers of Nevada Las Vegas, Nevada, United States, 89148
    • OptumCare Cancer Care at Fort Apache Las Vegas, Nevada, United States, 89148
    • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas, Nevada, United States, 89149
    • Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas, Nevada, United States, 89169
    • University Cancer Center Las Vegas, Nevada, United States, 89169
    • Hope Cancer Care of Nevada-Pahrump Pahrump, Nevada, United States, 89048
    • Renown Regional Medical Center Reno, Nevada, United States, 89502
    • Saint Mary's Regional Medical Center Reno, Nevada, United States, 89503
    • Radiation Oncology Associates Reno, Nevada, United States, 89509
  • United States, New Hampshire
    • Dartmouth Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756
  • United States, New Jersey
    • Memorial Sloan Kettering Basking Ridge Basking Ridge, New Jersey, United States, 07920
    • Memorial Sloan Kettering Monmouth Middletown, New Jersey, United States, 07748
    • Memorial Sloan Kettering Bergen Montvale, New Jersey, United States, 07645
    • Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903
  • United States, New York
    • Montefiore Medical Center-Einstein Campus Bronx, New York, United States, 10461
    • Montefiore Medical Center-Weiler Hospital Bronx, New York, United States, 10461
    • Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467
    • Roswell Park Cancer Institute Buffalo, New York, United States, 14263
    • Memorial Sloan Kettering Commack Commack, New York, United States, 11725
    • Memorial Sloan Kettering Westchester Harrison, New York, United States, 10604
    • Northwell Health/Center for Advanced Medicine Lake Success, New York, United States, 11042
    • North Shore University Hospital Manhasset, New York, United States, 11030
    • Long Island Jewish Medical Center New Hyde Park, New York, United States, 11040
    • Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065
    • University of Rochester Rochester, New York, United States, 14642
    • Stony Brook University Medical Center Stony Brook, New York, United States, 11794
    • Memorial Sloan Kettering Nassau Uniondale, New York, United States, 11553
  • United States, North Carolina
    • AdventHealth Infusion Center Asheville Asheville, North Carolina, United States, 28803
    • UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599
    • AdventHealth Infusion Center Haywood Clyde, North Carolina, United States, 28721
    • AdventHealth Hendersonville Hendersonville, North Carolina, United States, 28792
    • Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157
  • United States, Ohio
    • Indu and Raj Soin Medical Center Beavercreek, Ohio, United States, 45431
    • Saint Elizabeth Boardman Hospital Boardman, Ohio, United States, 44512
    • Toledo Clinic Cancer Centers-Bowling Green Bowling Green, Ohio, United States, 43402
    • Dayton Physicians LLC-Miami Valley South Centerville, Ohio, United States, 45459
    • Miami Valley Hospital South Centerville, Ohio, United States, 45459
    • Oncology Hematology Care Inc-Eden Park Cincinnati, Ohio, United States, 45202
    • Oncology Hematology Care Inc-Mercy West Cincinnati, Ohio, United States, 45211
    • University of Cincinnati/Barrett Cancer Center Cincinnati, Ohio, United States, 45219
    • Oncology Hematology Care Inc - Anderson Cincinnati, Ohio, United States, 45230
    • Oncology Hematology Care Inc-Kenwood Cincinnati, Ohio, United States, 45236
    • Oncology Hematology Care Inc-Blue Ash Cincinnati, Ohio, United States, 45242
    • Case Western Reserve University Cleveland, Ohio, United States, 44106
    • Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195
    • Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210
    • Good Samaritan Hospital - Dayton Dayton, Ohio, United States, 45406
    • Miami Valley Hospital Dayton, Ohio, United States, 45409
    • Dayton Physician LLC-Miami Valley Hospital North Dayton, Ohio, United States, 45415
    • Miami Valley Hospital North Dayton, Ohio, United States, 45415
    • Oncology Hematology Care Inc-Healthplex Fairfield, Ohio, United States, 45014
    • Armes Family Cancer Center Findlay, Ohio, United States, 45840
    • Blanchard Valley Hospital Findlay, Ohio, United States, 45840
    • Orion Cancer Care Findlay, Ohio, United States, 45840
    • Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio, United States, 45005-1066
    • Dayton Physicians LLC-Atrium Franklin, Ohio, United States, 45005
    • Dayton Physicians LLC-Wayne Greenville, Ohio, United States, 45331
    • Wayne Hospital Greenville, Ohio, United States, 45331
    • Greater Dayton Cancer Center Kettering, Ohio, United States, 45409
    • First Dayton Cancer Care Kettering, Ohio, United States, 45420
    • Kettering Medical Center Kettering, Ohio, United States, 45429
    • Lima Memorial Hospital Lima, Ohio, United States, 45804
    • Toledo Clinic Cancer Centers-Maumee Maumee, Ohio, United States, 43537
    • Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee, Ohio, United States, 43537
    • Dayton Physicians LLC-Signal Point Middletown, Ohio, United States, 45042
    • Saint Charles Hospital Oregon, Ohio, United States, 43616
    • Toledo Clinic Cancer Centers-Oregon Oregon, Ohio, United States, 43616
    • Dayton Physicians LLC-Wilson Sidney, Ohio, United States, 45365
    • Springfield Regional Cancer Center Springfield, Ohio, United States, 45504
    • Springfield Regional Medical Center Springfield, Ohio, United States, 45505
    • ProMedica Flower Hospital Sylvania, Ohio, United States, 43560
    • Mercy Hospital of Tiffin Tiffin, Ohio, United States, 44883
    • The Toledo Hospital/Toledo Children's Hospital Toledo, Ohio, United States, 43606
    • Saint Vincent Mercy Medical Center Toledo, Ohio, United States, 43608
    • University of Toledo Toledo, Ohio, United States, 43614
    • Toledo Community Hospital Oncology Program CCOP Toledo, Ohio, United States, 43617
    • Mercy Saint Anne Hospital Toledo, Ohio, United States, 43623
    • Toledo Clinic Cancer Centers-Toledo Toledo, Ohio, United States, 43623
    • Dayton Physicians LLC-Upper Valley Troy, Ohio, United States, 45373
    • Upper Valley Medical Center Troy, Ohio, United States, 45373
    • Saint Joseph Warren Hospital Warren, Ohio, United States, 44484
    • Fulton County Health Center Wauseon, Ohio, United States, 43567
    • University Pointe West Chester, Ohio, United States, 45069
    • Wright-Patterson Medical Center Wright-Patterson Air Force Base, Ohio, United States, 45433-5529
    • Saint Elizabeth Youngstown Hospital Youngstown, Ohio, United States, 44501
  • United States, Oklahoma
    • University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, United States, 73104
    • Mercy Hospital Oklahoma City Oklahoma City, Oklahoma, United States, 73120
  • United States, Oregon
    • Saint Alphonsus Medical Center-Baker City Baker City, Oregon, United States, 97814
    • Saint Charles Health System Bend, Oregon, United States, 97701
    • Clackamas Radiation Oncology Center Clackamas, Oregon, United States, 97015
    • Providence Oncology and Hematology Care Southeast Clackamas, Oregon, United States, 97015
    • Bay Area Hospital Coos Bay, Oregon, United States, 97420
    • Providence Newberg Medical Center Newberg, Oregon, United States, 97132
    • Saint Alphonsus Medical Center-Ontario Ontario, Oregon, United States, 97914
    • Providence Willamette Falls Medical Center Oregon City, Oregon, United States, 97045
    • Providence Portland Medical Center Portland, Oregon, United States, 97213
    • Providence Saint Vincent Medical Center Portland, Oregon, United States, 97225
    • Saint Charles Health System-Redmond Redmond, Oregon, United States, 97756
  • United States, Pennsylvania
    • Geisinger Medical Center Danville, Pennsylvania, United States, 17822
    • Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850
    • University of Pennsylvania/Abramson Cancer Center Philadelphia, Pennsylvania, United States, 19104
    • Thomas Jefferson University Hospital Philadelphia, Pennsylvania, United States, 19107
    • Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111
    • University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232
    • Community Medical Center Scranton, Pennsylvania, United States, 18510
  • United States, South Carolina
    • AnMed Health Cancer Center Anderson, South Carolina, United States, 29621
    • Greenville Health System Cancer Institute-Easley Easley, South Carolina, United States, 29640
    • Gibbs Cancer Center-Gaffney Gaffney, South Carolina, United States, 29341
    • Greenville Health System Cancer Institute-Andrews Greenville, South Carolina, United States, 29601
    • Saint Francis Hospital Greenville, South Carolina, United States, 29601
    • Greenville Health System Cancer Institute-Butternut Greenville, South Carolina, United States, 29605
    • Greenville Health System Cancer Institute-Faris Greenville, South Carolina, United States, 29605
    • Greenville Memorial Hospital Greenville, South Carolina, United States, 29605
    • Saint Francis Cancer Center Greenville, South Carolina, United States, 29607
    • Greenville Health System Cancer Institute-Eastside Greenville, South Carolina, United States, 29615
    • Greenville Health System Cancer Institute-Greer Greer, South Carolina, United States, 29650
    • Gibbs Cancer Center-Pelham Greer, South Carolina, United States, 29651
    • Carolina Blood and Cancer Care Associates PA-Lancaster Lancaster, South Carolina, United States, 29720
    • Carolina Blood and Cancer Care Associates PA Rock Hill, South Carolina, United States, 29732
    • Greenville Health System Cancer Institute-Seneca Seneca, South Carolina, United States, 29672
    • Spartanburg Medical Center Spartanburg, South Carolina, United States, 29303
    • Greenville Health System Cancer Institute-Spartanburg Spartanburg, South Carolina, United States, 29307
  • United States, Tennessee
    • Vanderbilt-Ingram Cancer Center Cool Springs Franklin, Tennessee, United States, 37067
    • Vanderbilt Breast Center at One Hundred Oaks Nashville, Tennessee, United States, 37204
    • Vanderbilt University/Ingram Cancer Center Nashville, Tennessee, United States, 37232
  • United States, Texas
    • Parkland Memorial Hospital Dallas, Texas, United States, 75235
    • UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas, United States, 75390
    • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston, Texas, United States, 77030
    • Ben Taub General Hospital Houston, Texas, United States, 77030
  • United States, Utah
    • American Fork Hospital / Huntsman Intermountain Cancer Center American Fork, Utah, United States, 84003
    • Sandra L Maxwell Cancer Center Cedar City, Utah, United States, 84720
    • Farmington Health Center Farmington, Utah, United States, 84025
    • Logan Regional Hospital Logan, Utah, United States, 84321
    • Intermountain Medical Center Murray, Utah, United States, 84107
    • McKay-Dee Hospital Center Ogden, Utah, United States, 84403
    • Utah Valley Regional Medical Center Provo, Utah, United States, 84604
    • Riverton Hospital Riverton, Utah, United States, 84065
    • Dixie Medical Center Regional Cancer Center Saint George, Utah, United States, 84770
    • Utah Cancer Specialists-Salt Lake City Salt Lake City, Utah, United States, 84106
    • Huntsman Cancer Institute/University of Utah Salt Lake City, Utah, United States, 84112
    • LDS Hospital Salt Lake City, Utah, United States, 84143
    • South Jordan Health Center South Jordan, Utah, United States, 84009
  • United States, Virginia
    • Fredericksburg Oncology Inc Fredericksburg, Virginia, United States, 22401
    • VCU Massey Cancer Center at Stony Point Richmond, Virginia, United States, 23235
    • Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298
  • United States, Washington
    • Providence Regional Cancer System-Aberdeen Aberdeen, Washington, United States, 98520
    • Cancer Care Center at Island Hospital Anacortes, Washington, United States, 98221
    • Swedish Cancer Institute-Eastside Oncology Hematology Bellevue, Washington, United States, 98005
    • PeaceHealth Saint Joseph Medical Center Bellingham, Washington, United States, 98225
    • Providence Regional Cancer System-Centralia Centralia, Washington, United States, 98531
    • Swedish Cancer Institute-Edmonds Edmonds, Washington, United States, 98026
    • Providence Regional Cancer Partnership Everett, Washington, United States, 98201
    • Swedish Cancer Institute-Issaquah Issaquah, Washington, United States, 98029
    • Kadlec Clinic Hematology and Oncology Kennewick, Washington, United States, 99336
    • Providence Regional Cancer System-Lacey Lacey, Washington, United States, 98503
    • PeaceHealth Saint John Medical Center Longview, Washington, United States, 98632
    • Minor and James Medical PLLC Seattle, Washington, United States, 98104
    • Pacific Gynecology Specialists Seattle, Washington, United States, 98104
    • Swedish Medical Center-Ballard Campus Seattle, Washington, United States, 98107
    • Kaiser Permanente Washington Seattle, Washington, United States, 98112
    • Swedish Medical Center-First Hill Seattle, Washington, United States, 98122-4307
    • Swedish Medical Center-Cherry Hill Seattle, Washington, United States, 98122-5711
    • PeaceHealth United General Medical Center Sedro-Woolley, Washington, United States, 98284
    • Providence Regional Cancer System-Shelton Shelton, Washington, United States, 98584
    • Rockwood Clinic Cancer Treatment Center-Valley Spokane Valley, Washington, United States, 99216
    • Rockwood Cancer Treatment Center-DHEC-Downtown Spokane, Washington, United States, 99204
    • Evergreen Hematology and Oncology PS Spokane, Washington, United States, 99218
    • Rockwood North Cancer Treatment Center Spokane, Washington, United States, 99218
    • PeaceHealth Southwest Medical Center Vancouver, Washington, United States, 98664
    • Providence Saint Mary Regional Cancer Center Walla Walla, Washington, United States, 99362
    • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima, Washington, United States, 98902
    • Providence Regional Cancer System-Yelm Yelm, Washington, United States, 98597
  • United States, Wisconsin
    • Marshfield Clinic Cancer Center at Sacred Heart Eau Claire, Wisconsin, United States, 54701
    • Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin, United States, 54701
    • Green Bay Oncology at Saint Vincent Hospital Green Bay, Wisconsin, United States, 54301-3526
    • Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin, United States, 54301
    • Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin, United States, 54303
    • Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin, United States, 54303
    • Gundersen Lutheran Medical Center La Crosse, Wisconsin, United States, 54601
    • University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792
    • Holy Family Memorial Hospital Manitowoc, Wisconsin, United States, 54221
    • Saint Vincent Hospital Cancer Center at Marinette Marinette, Wisconsin, United States, 54143
    • Marshfield Medical Center-Marshfield Marshfield, Wisconsin, United States, 54449
    • Marshfield Medical Center Marshfield, Wisconsin, United States, 54449
    • Froedtert and the Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226
    • Marshfield Clinic-Minocqua Center Minocqua, Wisconsin, United States, 54548
    • Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls, Wisconsin, United States, 54154
    • Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin, United States, 54868
    • HSHS Saint Nicholas Hospital Sheboygan, Wisconsin, United States, 53081
    • Marshfield Clinic Stevens Point Center Stevens Point, Wisconsin, United States, 54482
    • Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay, Wisconsin, United States, 54235-1495
    • Green Bay Oncology - Sturgeon Bay Sturgeon Bay, Wisconsin, United States, 54235
    • Marshfield Clinic-Wausau Center Wausau, Wisconsin, United States, 54401
    • Marshfield Clinic - Weston Center Weston, Wisconsin, United States, 54476
  • United States, Wyoming
    • Rocky Mountain Oncology Casper, Wyoming, United States, 82609
    • Cheyenne Regional Medical Center-West Cheyenne, Wyoming, United States, 82001
    • Big Horn Basin Cancer Center Cody, Wyoming, United States, 82414
    • Billings Clinic-Cody Cody, Wyoming, United States, 82414
    • Welch Cancer Center Sheridan, Wyoming, United States, 82801
  • Canada, Alberta
    • Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2
  • Canada, British Columbia
    • Clinical Research Unit at Vancouver Coastal Health Authority Vancouver, British Columbia, Canada, V5Z 3P1
  • Canada, Nova Scotia
    • QEII Health Sciences Centre/Nova Scotia Health Authority Halifax, Nova Scotia, Canada, B3H 2Y9
  • Canada, Ontario
    • Kingston Health Sciences Centre Kingston, Ontario, Canada, K7L 2V7
  • Canada, Quebec
    • CIUSSSEMTL-Hopital Maisonneuve-Rosemont Montreal, Quebec, Canada, H1T 2M4
  • Canada, Saskatchewan
    • Allan Blair Cancer Centre Regina, Saskatchewan, Canada, S4T 7T1
  • Israel,
    • Rambam Medical Center Haifa, , Israel, 31096
    • Shaare Zedek Medical Center Jerusalem, , Israel, 91031

Sponsors and Collaborators

National Cancer Institute (NCI)

Canadian Cancer Trials Group

More Information

No publications provided

Responsible Party: Sponsor
ClinicalTrials.gov Identifier: NCT02003222
Other Study ID Numbers: NCI-2013-02229
Study First Received:
Last Updated:
Health Authority:

Additional relevant MeSH terms:

Leukemia

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Leukemia, Lymphoid

Philadelphia Chromosome

Dexamethasone

Prednisone

Cortisone

Dexamethasone acetate

Cyclophosphamide

Rituximab

Methotrexate

Etoposide

Cytarabine

Vincristine

Daunorubicin

Asparaginase

Mercaptopurine

Blinatumomab

Pegaspargase

Etoposide phosphate

Podophyllotoxin

Muromonab-CD3

Antibodies

Immunoglobulins

Antibodies, Monoclonal

Antibodies, Bispecific

Visilizumab

Antineoplastic Agents, Immunological

BB 1101

Next Steps


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ClinicalTrials.gov processed this data on May 30, 2019