Clinical Trial - NCT01872975

Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

Recruiting

Sponsor: NSABP Foundation Inc

Collaborators: National Cancer Institute (NCI), Radiation Therapy Oncology Group

Information provided by (Responsible party): Sponsor

ClinicalTrials.gov Identifier: NCT01872975

Protocol Info

Short Description: Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery
Long Description: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
MGH Status: Open
Sponsor: NRG Oncology
Disease Program: Breast

Next Steps


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Purpose

This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet known whether comprehensive radiation therapy is more effective than standard radiation therapy in treating patients with breast cancer
Condition Title Intervention Phase
Stage IB Breast Cancer Stage II Breast Cancer regional nodal XRT chestwall XRT WBI N/A
Study Type Interventional
Official Title A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

Primary Outcome Measures

IBC-RFI [Time Frame: Time from randomization until invasive local, regional, or distant recurrence, or death from breast cancer, assessed up to 10 years] [Designated as safety issue: ]


Secondary Outcome Measures

OS [Time Frame: Time from randomization to death from any cause, assessed up to 10 years] [Designated as safety issue: ]

LRRFI [Time Frame: Time from randomization to recurrence of primary cancer w/in breast or lymph nodes in ipsilateral axilla, infraclavicular fossa, or ipsilateral internal mammary chain w/out evidence distant disease, or death due to breast cancer, assessed up to 10 years] [Designated as safety issue: ]

DRFI [Time Frame: Time from randomization to the development of tumor in all areas beyond local or regional limits, or death due to breast cancer, assessed up to 10 years] [Designated as safety issue: ]

DFS-DCIS [Time Frame: Time from randomization to local recurrence post-mastectomy/in ipsilateral breast post-lumpectomy, regional/distant recurrence, contralateral disease, second primary cancer, or death from any cause prior to recurrence or SPC, assessed up to 10 years] [Designated as safety issue: ]

Time to SPC [Time Frame: Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 10 years] [Designated as safety issue: ]

Effect of radiation therapy on cosmetic outcome in mastectomy and lumpectomy patients as assessed by quality of life questionnaire [Time Frame: Assessed prior to randomization, 3 months or at end of RT, and 6, 12, and 24 months from randomization] [Designated as safety issue: ]

Frequencies of adverse events graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [Time Frame: Up to 30 days after completion of study treatment] [Designated as safety issue: ]

Molecular predictors of recurrence [Time Frame: Tissue samples collected within 90 days after randomization] [Designated as safety issue: ]

Estimated Enrollment: 1636
Study Start Date: August 2013
Estimated Study Completion Date: August 2028
Estimated Primary Completion Date: July 2023
Arms Assigned Interventions

Active Comparator:Group 1A Lumpectomy: no regional nodal XRT with WBI

Lumpectomy patients undergo whole breast radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.
Radiation:WBI

No Intervention:Group 1B Mastectomy: No regional nodal or chestwall XRT

Mastectomy patients do not undergo radiation therapy.

Experimental:Group 2A lumpectomy: Regional nodal XRT with WBI

Lumpectomy patients undergo regional nodal radiation therapy with whole breast radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.
Radiation:regional nodal XRT

Experimental:Group 2B Mastectomy: Regional nodal XRT and chestwall XRT

Mastectomy patients undergo regional nodal radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks.
Radiation:chestwall XRT

Eligibility

Ages Eligible for Study: N/A-N/A

Genders Eligible for Study: Female

Accepts Healthly Volunteers: No

Inclusion Criteria:

  • The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
  • The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • Patient must have clinically T1-3, N1 breast cancer at the time of diagnosis (before neoadjuvant therapy); clinical axillary nodal involvement can be assessed by palpation, ultrasound, CT scan, magnetic resonance imaging (MRI), positron emission tomography (PET) scan, or PET/CT scan
  • Patient must have had pathologic confirmation of axillary nodal involvement at presentation (before neoadjuvant therapy) based on either a positive fine needle aspirate (FNA) (demonstrating malignant cells) or positive core needle biopsy (demonstrating invasive adenocarcinoma); the FNA or core needle biopsy can be performed either by palpation or by image guidance; documentation of axillary nodal positivity by sentinel node biopsy (before neoadjuvant therapy) is not permitted
  • Patients must have had estrogen receptor (ER) analysis performed on the primary breast tumor before neoadjuvant therapy according to current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for hormone receptor testing; if negative for ER, assessment of progesterone receptor (PgR) must also be performed according to current ASCO/CAP guideline recommendations for hormone receptor testing (http://www.asco.org)
  • Patients must have had HER2 testing performed on the primary breast tumor before neoadjuvant chemotherapy according to the current ASCO/CAP guideline recommendations for human epidermal growth factor receptor 2 testing in Breast Cancer (http://www.asco.org); patients who have a primary tumor that is either HER2-positive or HER2-negative are eligible
  • Patient must have completed a minimum of 8 weeks of standard neoadjuvant chemotherapy consisting of an anthracycline and/or taxane-based regimen
  • For patients who receive adjuvant chemotherapy after surgery, a maximum of 12 weeks of intended chemotherapy may be administered but must be completed before randomization; (if treatment delays occur, chemotherapy must be completed within 14 weeks); the dose and schedule of the adjuvant chemotherapy are at the investigator's discretion; Note: It is preferred that all intended chemotherapy be administered in the neoadjuvant setting
  • Patients with HER2-positive tumors must have received neoadjuvant anti-HER2 therapy (either with all or with a portion of the neoadjuvant chemotherapy regimen), unless medically contraindicated
  • At the time of definitive surgery, all removed axillary nodes must be histologically free from cancer; acceptable procedures for assessment of axillary nodal status at the time of surgery include:
  • Axillary node dissection
  • Sentinel node biopsy alone or
  • Sentinel node biopsy followed by axillary node dissection
  • Note: Patients are eligible whether there is residual invasive carcinoma in the surgical breast specimen or whether there is evidence of pathologic complete response; patients who are found to be pathologically node-positive at the time of surgery, based on sentinel node biopsy alone, are candidates for A011202, a study developed by the Alliance in Oncology, an NCI Cooperative Group; if A011202 is open at the investigator's institution, patients should be approached about participating in the A011202 study
  • Patients with pathologic staging of ypN0(i+) or ypN0(mol+) are eligible (Note: Postneoadjuvant therapy is designated with a "yp" prefix.)
  • Patient who have undergone either a total mastectomy or a lumpectomy are eligible
  • For patients who undergo lumpectomy, the margins of the resected specimen or re-excision must be histologically free of invasive tumor and DCIS as determined by the local pathologist; additional operative procedures may be performed to obtain clear margins; if tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible; (patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection)
  • For patients who undergo mastectomy, the margins must be histologically free of residual (microscopic or gross) tumor
  • The interval between the last surgery for breast cancer (including re-excision of margins) and randomization must be no more than 70 days; also, if adjuvant chemotherapy was administered, the interval between the last chemotherapy treatment and randomization must be no more than 70 days
  • The patient must have recovered from surgery with the incision completely healed and no signs of infection
  • If adjuvant chemotherapy was administered, chemotherapy-related toxicity that may interfere with delivery of radiation therapy should have resolved

Exclusion Criteria:

  • Definitive clinical or radiologic evidence of metastatic disease
  • T4 tumors including inflammatory breast cancer
  • Documentation of axillary nodal positivity before neoadjuvant therapy by sentinel node biopsy alone
  • N2 or N3 disease detected clinically or by imaging
  • Patients with histologically positive axillary nodes post neoadjuvant therapy
  • Patients with microscopic positive margins after definitive surgery
  • Synchronous or previous contralateral invasive breast cancer or DCIS; (patients with synchronous and/or previous contralateral LCIS are eligible)
  • Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy; (patients with synchronous or previous ipsilateral LCIS are eligible)
  • History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
  • Any radiation therapy for the currently diagnosed breast cancer prior to randomization
  • Any continued use of sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy; patients are eligible if these medications are discontinued prior to randomization
  • Prior breast or thoracic radiation therapy (RT) for any condition
  • Active collagen vascular disease, specifically dermatomyositis with a creatinine phosphokinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma
  • Pregnancy or lactation at the time of study entry; (Note: Pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
  • Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up
  • Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01872975

Locations

  • United States, Alabama
    • University of Alabama at Birmingham Cancer Center Birmingham, Alabama, United States, 35233
    • University of South Alabama Mitchell Cancer Institute Mobile, Alabama, United States, 36688
  • United States, Alaska
    • Providence Alaska Medical Center Anchorage, Alaska, United States, 99508
  • United States, Arizona
    • Arizona Breast Cancer Specialists-Gilbert Gilbert, Arizona, United States, 85297
    • Arizona Center for Cancer Care-Peoria Peoria, Arizona, United States, 85381
    • Arizona Breast Cancer Specialists-Phoenix Phoenix, Arizona, United States, 85027
    • Arizona Breast Cancer Specialists-Scottsdale Scottsdale, Arizona, United States, 85258
    • Arizona Center for Cancer Care-Surprise Surprise, Arizona, United States, 85374
    • Arizona Oncology Associates-West Orange Grove Tucson, Arizona, United States, 85704
    • The University of Arizona Medical Center-University Campus Tucson, Arizona, United States, 85724
  • United States, Arkansas
    • University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205
  • United States, California
    • Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn, California, United States, 95603
    • Mills - Peninsula Hospitals Burlingame, California, United States, 94010
    • Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park, California, United States, 95682
    • Eden Hospital Medical Center Castro Valley, California, United States, 94546
    • City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010
    • Epic Care-Dublin Dublin, California, United States, 94568
    • Epic Care Partners in Cancer Care Emeryville, California, United States, 94608
    • California Cancer Center - North Fresno Fresno, California, United States, 93720
    • UC San Diego Moores Cancer Center La Jolla, California, United States, 92093
    • City of Hope Antelope Valley Lancaster, California, United States, 93534
    • Loma Linda University Medical Center Loma Linda, California, United States, 92354
    • Los Angeles County-USC Medical Center Los Angeles, California, United States, 90033
    • USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033
    • Cedars-Sinai Medical Center Los Angeles, California, United States, 90048
    • Hoag Memorial Hospital Newport Beach, California, United States, 92663
    • Alta Bates Summit Medical Center - Summit Campus Oakland, California, United States, 94609
    • Kaiser Permanente Oakland-Broadway Oakland, California, United States, 94611
    • Saint Joseph Hospital - Orange Orange, California, United States, 92868
    • UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California, United States, 92868
    • Desert Regional Medical Center Palm Springs, California, United States, 92262
    • Stanford Cancer Institute Palo Alto, California, United States, 94304
    • Huntington Memorial Hospital Pasadena, California, United States, 91105
    • Pomona Valley Hospital Medical Center Pomona, California, United States, 91767
    • Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova, California, United States, 95670
    • Rohnert Park Cancer Center Rohnert Park, California, United States, 94928
    • Kaiser Permanente-Roseville Roseville, California, United States, 95661
    • Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville, California, United States, 95661
    • Sutter Roseville Medical Center Roseville, California, United States, 95661
    • The Permanente Medical Group-Roseville Radiation Oncology Roseville, California, United States, 95678
    • Sutter General Hospital Sacramento, California, United States, 95816
    • University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817
    • Saint Helena Hospital Saint Helena, California, United States, 94574
    • Naval Medical Center -San Diego San Diego, California, United States, 92134
    • Kaiser Permanente Medical Center - Santa Clara Santa Clara, California, United States, 95051
    • City of Hope South Pasadena South Pasadena, California, United States, 91030
    • Kaiser Permanente Cancer Treatment Center South San Francisco, California, United States, 94080
    • Kaiser Permanente-South San Francisco South San Francisco, California, United States, 94080
    • Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee, California, United States, 96161
    • Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville, California, United States, 95687
    • Sutter Solano Medical Center/Cancer Center Vallejo, California, United States, 94589
  • United States, Colorado
    • Rocky Mountain Cancer Centers-Aurora Aurora, Colorado, United States, 80012
    • University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045
    • Rocky Mountain Cancer Centers-Boulder Boulder, Colorado, United States, 80304
    • Penrose-Saint Francis Healthcare Colorado Springs, Colorado, United States, 80907
    • Memorial Hospital Colorado Springs Colorado Springs, Colorado, United States, 80909
    • Porter Adventist Hospital Denver, Colorado, United States, 80210
    • The Shaw Regional Cancer Center Edwards, Colorado, United States, 81632
    • Poudre Valley Hospital Fort Collins, Colorado, United States, 80524
    • Rocky Mountain Cancer Centers-Littleton Littleton, Colorado, United States, 80120
    • Saint Mary Corwin Medical Center Pueblo, Colorado, United States, 81004
    • Rocky Mountain Cancer Centers-Thornton Thornton, Colorado, United States, 80260
    • SCL Health Lutheran Medical Center Wheat Ridge, Colorado, United States, 80033
  • United States, Connecticut
    • Hartford Hospital Hartford, Connecticut, United States, 06102
    • Middlesex Hospital Middletown, Connecticut, United States, 06457
    • The Hospital of Central Connecticut New Britain, Connecticut, United States, 06050
    • Yale-New Haven Hospital Saint Raphael Campus New Haven, Connecticut, United States, 06511
    • Yale University New Haven, Connecticut, United States, 06520
  • United States, District of Columbia
    • MedStar Georgetown University Hospital Washington, D.C., District of Columbia, United States, 20007
    • MedStar Washington Hospital Center Washington, D.C., District of Columbia, United States, 20010
    • Sibley Memorial Hospital Washington, D.C., District of Columbia, United States, 20016
  • United States, Florida
    • Florida Hospital Cancer Institute Altamonte Altamonte Springs, Florida, United States, 32701
    • John Fitzgerald Kennedy Medical Center Atlantis, Florida, United States, 33462
    • Morton Plant Hospital Clearwater, Florida, United States, 33756
    • UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach, Florida, United States, 33442
    • University of Florida Gainesville, Florida, United States, 32610
    • Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood, Florida, United States, 33021
    • Jackson Memorial Hospital-Holtz Children's Hospital Miami, Florida, United States, 33136
    • University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida, United States, 33136
    • South Miami Hospital Miami, Florida, United States, 33143
    • Baptist Hospital of Miami Miami, Florida, United States, 33176
    • Florida Hospital Orlando Orlando, Florida, United States, 32803
    • UF Cancer Center at Orlando Health Orlando, Florida, United States, 32806
    • 21st Century Oncology-Palatka Palatka, Florida, United States, 32177
    • Saint Joseph's Hospital/Children's Hospital-Tampa Tampa, Florida, United States, 33607
    • Moffitt Cancer Center Tampa, Florida, United States, 33612
  • United States, Georgia
    • Grady Health System Atlanta, Georgia, United States, 30303
    • Emory University Hospital Midtown Atlanta, Georgia, United States, 30308
    • Piedmont Hospital Atlanta, Georgia, United States, 30309
    • Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322
    • Saint Joseph's Hospital of Atlanta Atlanta, Georgia, United States, 30342
    • Tanner Medical Center/Carrollton Carrollton, Georgia, United States, 30117
    • Dekalb Medical Center Decatur, Georgia, United States, 30033
    • Memorial University Medical Center Savannah, Georgia, United States, 31404
    • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah, Georgia, United States, 31405
  • United States, Hawaii
    • The Cancer Center of Hawaii-Leeward 'Ewa Beach, Hawaii, United States, 96706
    • Queen's Medical Center Honolulu, Hawaii, United States, 96813
    • The Cancer Center of Hawaii-Liliha Honolulu, Hawaii, United States, 96817
  • United States, Idaho
    • Saint Alphonsus Cancer Care Center-Boise Boise, Idaho, United States, 83706
    • Kootenai Cancer Center Post Falls, Idaho, United States, 83854
  • United States, Illinois
    • Mount Sinai Hospital Medical Center Chicago, Illinois, United States, 60608
    • Northwestern University Chicago, Illinois, United States, 60611
    • John H Stroger Jr Hospital of Cook County Chicago, Illinois, United States, 60612
    • University of Illinois Chicago, Illinois, United States, 60612
    • University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637
    • Advocate Illinois Masonic Medical Center Chicago, Illinois, United States, 60657
    • Decatur Memorial Hospital Decatur, Illinois, United States, 62526
    • AMITA Health Alexian Brothers Medical Center Elk Grove Village, Illinois, United States, 60007
    • Elmhurst Memorial Hospital Elmhurst, Illinois, United States, 60126
    • NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201
    • NorthShore University HealthSystem-Glenbrook Hospital Glenview, Illinois, United States, 60026
    • Advocate South Suburban Hospital Hazel Crest, Illinois, United States, 60429
    • NorthShore University HealthSystem-Highland Park Hospital Highland Park, Illinois, United States, 60035
    • Presence Saint Mary's Hospital Kankakee, Illinois, United States, 60901
    • Condell Memorial Hospital Libertyville, Illinois, United States, 60048
    • Loyola University Medical Center Maywood, Illinois, United States, 60153
    • Edward Hospital/Cancer Center Naperville, Illinois, United States, 60540
    • UC Comprehensive Cancer Center at Silver Cross New Lenox, Illinois, United States, 60451
    • Advocate Christ Medical Center Oak Lawn, Illinois, United States, 60453-2699
    • Advocate Lutheran General Hospital Park Ridge, Illinois, United States, 60068
    • Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615
    • OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria, Illinois, United States, 61615
    • OSF Saint Francis Medical Center Peoria, Illinois, United States, 61637
    • Edward Hospital/Cancer Center?Plainfield Plainfield, Illinois, United States, 60585
    • SwedishAmerican Regional Cancer Center/ACT Rockford, Illinois, United States, 61114
    • Memorial Medical Center Springfield, Illinois, United States, 62781
    • Carle Cancer Center Urbana, Illinois, United States, 61801
    • Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois, United States, 60555
  • United States, Indiana
    • Saint Vincent Anderson Regional Hospital/Cancer Center Anderson, Indiana, United States, 46016
    • Parkview Hospital Randallia Fort Wayne, Indiana, United States, 46805
    • Goshen Center for Cancer Care Goshen, Indiana, United States, 46526
    • Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202
    • IU Health Methodist Hospital Indianapolis, Indiana, United States, 46202
    • Community Cancer Center East Indianapolis, Indiana, United States, 46219
    • Community Cancer Center South Indianapolis, Indiana, United States, 46227
    • Franciscan Health Indianapolis Indianapolis, Indiana, United States, 46237
    • Community Cancer Center North Indianapolis, Indiana, United States, 46256
    • Saint Vincent Hospital and Health Care Center Indianapolis, Indiana, United States, 46260
    • Memorial Hospital of South Bend South Bend, Indiana, United States, 46601
  • United States, Iowa
    • Mercy Cancer Center-West Lakes Clive, Iowa, United States, 50325
    • Iowa Methodist Medical Center Des Moines, Iowa, United States, 50309
    • Mercy Medical Center - Des Moines Des Moines, Iowa, United States, 50314
    • University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa, United States, 52242
  • United States, Kansas
    • University of Kansas Cancer Center Kansas City, Kansas, United States, 66160
    • University of Kansas Cancer Center-Overland Park Overland Park, Kansas, United States, 66210
    • Via Christi Regional Medical Center Wichita, Kansas, United States, 67214
    • Wesley Medical Center Wichita, Kansas, United States, 67214
    • Wichita NCI Community Oncology Research Program Wichita, Kansas, United States, 67214
  • United States, Kentucky
    • Saint Elizabeth Medical Center South Edgewood, Kentucky, United States, 41017
    • Saint Elizabeth Fort Thomas Fort Thomas, Kentucky, United States, 41075
    • University of Kentucky/Markey Cancer Center Lexington, Kentucky, United States, 40536
    • Norton Hospital Pavilion and Medical Campus Louisville, Kentucky, United States, 40202
    • The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky, United States, 40202
    • Baptist Health Louisville Louisville, Kentucky, United States, 40207
    • Norton Suburban Hospital and Medical Campus Louisville, Kentucky, United States, 40207
    • Owensboro Health Mitchell Memorial Cancer Center Owensboro, Kentucky, United States, 42303
  • United States, Louisiana
    • Baton Rouge General Medical Center Baton Rouge, Louisiana, United States, 70806
    • Mary Bird Perkins Cancer Center Baton Rouge, Louisiana, United States, 70809
    • Woman's Hospital Baton Rouge, Louisiana, United States, 70817
    • Mary Bird Cancer Center/Saint Tammany Parish Covington, Louisiana, United States, 70433
    • Mary Bird Perkins Cancer Center/Terrebonne General Medical Center Houma, Louisiana, United States, 70360
    • Ochsner Medical Center Kenner Kenner, Louisiana, United States, 70065
    • Ochsner Medical Center Jefferson New Orleans, Louisiana, United States, 70121
  • United States, Maine
    • Eastern Maine Medical Center Bangor, Maine, United States, 04401
    • Maine Medical Center- Scarborough Campus Scarborough, Maine, United States, 04074
  • United States, Maryland
    • Anne Arundel Medical Center Annapolis, Maryland, United States, 21401
    • University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201
    • Greater Baltimore Medical Center Baltimore, Maryland, United States, 21204
    • MedStar Franklin Square Medical Center/Weinberg Cancer Institute Baltimore, Maryland, United States, 21237
    • Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287
    • Upper Chesapeake Medical Center Bel Air, Maryland, United States, 21014
    • Central Maryland Radiation Oncology in Howard County Columbia, Maryland, United States, 21044
    • Tate Cancer Center Glen Burnie, Maryland, United States, 21061
  • United States, Massachusetts
    • Boston Medical Center Boston, Massachusetts, United States, 02118
    • Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215
    • Saint Anne's Hospital Fall River, Massachusetts, United States, 02721
    • Lowell General Hospital Lowell, Massachusetts, United States, 01854
    • Baystate Medical Center Springfield, Massachusetts, United States, 01199
  • United States, Michigan
    • University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109
    • Henry Ford Cancer Institute¿Downriver Brownstown Charter Township, Michigan, United States, 48183
    • 21st Century Oncology-Clarkston Clarkston, Michigan, United States, 48346
    • Henry Ford Macomb Hospital-Clinton Township Clinton, Michigan, United States, 48038
    • Beaumont Hospital-Dearborn Dearborn, Michigan, United States, 48124
    • Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201
    • Henry Ford Hospital Detroit, Michigan, United States, 48202
    • Saint John Hospital and Medical Center Detroit, Michigan, United States, 48236
    • Hurley Medical Center Flint, Michigan, United States, 48502
    • Genesys Hurley Cancer Institute Flint, Michigan, United States, 48503
    • McLaren Cancer Institute-Flint Flint, Michigan, United States, 48532
    • Spectrum Health at Butterworth Campus Grand Rapids, Michigan, United States, 49503
    • Sparrow Hospital Lansing, Michigan, United States, 48912
    • McLaren Cancer Institute-Lapeer Region Lapeer, Michigan, United States, 48446
    • McLaren Cancer Institute-Macomb Mount Clemens, Michigan, United States, 48043
    • McLaren Cancer Institute-Central Michigan Mount Pleasant, Michigan, United States, 48858
    • Mercy Health Mercy Campus Muskegon, Michigan, United States, 49444
    • Assarian Cancer Center Novi, Michigan, United States, 48374-1236
    • McLaren Cancer Institute-Owosso Owosso, Michigan, United States, 48867
    • McLaren Cancer Institute-Northern Michigan Petoskey, Michigan, United States, 49770
    • Saint Joseph Mercy Oakland Pontiac, Michigan, United States, 48341
    • William Beaumont Hospital-Royal Oak Royal Oak, Michigan, United States, 48073
    • Providence Hospital-Southfield Cancer Center Southfield, Michigan, United States, 48075
    • 21st Century Oncology-Troy Troy, Michigan, United States, 48098
    • William Beaumont Hospital - Troy Troy, Michigan, United States, 48098
    • Saint John Macomb-Oakland Hospital Warren, Michigan, United States, 48093
    • Henry Ford West Bloomfield Hospital West Bloomfield Township, Michigan, United States, 48322
    • Metro Health Hospital Wyoming, Michigan, United States, 49519
  • United States, Minnesota
    • Mayo Clinic Health System in Albert Lea Albert Lea, Minnesota, United States, 56007
    • Fairview Ridges Hospital Burnsville, Minnesota, United States, 55337
    • Unity Hospital Fridley, Minnesota, United States, 55432
    • Mayo Clinic Health Systems-Mankato Mankato, Minnesota, United States, 56001
    • Abbott-Northwestern Hospital Minneapolis, Minnesota, United States, 55407
    • Mayo Clinic Radiation Therapy-Northfield Northfield, Minnesota, United States, 55057
    • Mayo Clinic Rochester, Minnesota, United States, 55905
    • Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota, United States, 56303
    • Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota, United States, 55416
    • Regions Hospital Saint Paul, Minnesota, United States, 55101
    • United Hospital Saint Paul, Minnesota, United States, 55102
    • Ridgeview Medical Center Waconia, Minnesota, United States, 55387
  • United States, Mississippi
    • University of Mississippi Medical Center Jackson, Mississippi, United States, 39216
    • Baptist Memorial Hospital-Desoto Southhaven, Mississippi, United States, 38671
  • United States, Missouri
    • Saint Francis Medical Center Cape Girardeau, Missouri, United States, 63703
    • Saint Luke's Hospital Chesterfield, Missouri, United States, 63017
    • University of Missouri - Ellis Fischel Columbia, Missouri, United States, 65212
    • Barnes-Jewish West County Hospital Creve Coeur, Missouri, United States, 63141
    • Saint Luke's Hospital of Kansas City Kansas City, Missouri, United States, 64111
    • North Kansas City Hospital Kansas City, Missouri, United States, 64116
    • The University of Kansas Cancer Center-South Kansas City, Missouri, United States, 64131
    • Research Medical Center Kansas City, Missouri, United States, 64132
    • The University of Kansas Cancer Center-North Kansas City, Missouri, United States, 64154
    • The University of Kansas Cancer Center-Lee's Summit Lee's Summit, Missouri, United States, 64064
    • Saint Luke's East - Lee's Summit Lee's Summit, Missouri, United States, 64086
    • Washington University School of Medicine Saint Louis, Missouri, United States, 63110
    • Saint Anthony's Medical Center Saint Louis, Missouri, United States, 63128
    • Siteman Cancer Center-South County Saint Louis, Missouri, United States, 63129
    • Missouri Baptist Medical Center Saint Louis, Missouri, United States, 63131
    • Siteman Cancer Center - Saint Peters Saint Peters, Missouri, United States, 63376
  • United States, Montana
    • Billings Clinic Cancer Center Billings, Montana, United States, 59101
    • Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana, United States, 59405
    • Kalispell Regional Medical Center Kalispell, Montana, United States, 59901
  • United States, Nebraska
    • CHI Health Saint Francis Grand Island, Nebraska, United States, 68803
    • Alegent Health Bergan Mercy Medical Center Omaha, Nebraska, United States, 68124
    • Alegent Health Lakeside Hospital Omaha, Nebraska, United States, 68130
    • University of Nebraska Medical Center Omaha, Nebraska, United States, 68198
  • United States, Nevada
    • Radiation Oncology Centers of Nevada Central Las Vegas, Nevada, United States, 89106
    • Renown Regional Medical Center Reno, Nevada, United States, 89502
  • United States, New Hampshire
    • Concord Hospital Concord, New Hampshire, United States, 03301
    • Dartmouth Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756
    • Elliot Hospital Manchester, New Hampshire, United States, 03103
  • United States, New Jersey
    • Memorial Sloan Kettering Cancer Center at Basking Ridge Basking Ridge, New Jersey, United States, 07920
    • Ocean Medical Center Bricktown, New Jersey, United States, 08724
    • Cooper Hospital University Medical Center Camden, New Jersey, United States, 08103
    • Englewood Hospital and Medical Center Englewood, New Jersey, United States, 07631
    • Saint Barnabas Medical Center Livingston, New Jersey, United States, 07039
    • Virtua Memorial Mount Holly, New Jersey, United States, 08060
    • Jersey Shore Medical Center Neptune City, New Jersey, United States, 07753
    • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital New Brunswick, New Jersey, United States, 08903
    • The Valley Hospital-Luckow Pavilion Paramus, New Jersey, United States, 07652
    • Capital Health Medical Center-Hopewell Pennington, New Jersey, United States, 08534
    • Riverview Medical Center/Booker Cancer Center Red Bank, New Jersey, United States, 07701
    • Valley Hospital Ridgewood, New Jersey, United States, 07450
    • Robert Wood Johnson University Hospital Somerset Somerville, New Jersey, United States, 08876
    • Sparta Cancer Treatment Center Sparta, New Jersey, United States, 07871
    • MD Anderson Cancer Center at Cooper-Voorhees Voorhees, New Jersey, United States, 08043
    • Virtua Voorhees Voorhees, New Jersey, United States, 08043
    • Valley Health System-Hematology/Oncology Westwood, New Jersey, United States, 07675
  • United States, New Mexico
    • University of New Mexico Cancer Center Albuquerque, New Mexico, United States, 87102
    • Lovelace Radiation Oncology Albuquerque, New Mexico, United States, 87109
    • New Mexico Oncology Hematology Consultants Albuquerque, New Mexico, United States, 87109
    • Memorial Medical Center - Las Cruces Las Cruces, New Mexico, United States, 88011
    • Christus Saint Vincent Regional Cancer Center Santa Fe, New Mexico, United States, 87505
  • United States, New York
    • New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn, New York, United States, 11215
    • Maimonides Medical Center Brooklyn, New York, United States, 11219
    • Putnam Hospital Center Carmel, New York, United States, 10512
    • Memorial Sloan Kettering Commack Commack, New York, United States, 11725
    • Mary Imogene Bassett Hospital Cooperstown, New York, United States, 13326
    • Vassar Brothers Fishkill Radiation Oncology Center Fishkill, New York, United States, 12524
    • Memorial Sloan Kettering Westchester Harrison, New York, United States, 10604
    • Ulster Radiation Oncology Center Kingston, New York, United States, 12401
    • Columbia University/Herbert Irving Cancer Center New York, New York, United States, 10032
    • Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065
    • Vassar Brothers Medical Center Poughkeepsie, New York, United States, 12601
    • Rochester General Hospital Rochester, New York, United States, 14621
    • Pluta Cancer Center Rochester, New York, United States, 14623
    • Memorial Sloan Kettering Rockville Centre Rockville Centre, New York, United States, 11570
    • Memorial Sloan Kettering Sleepy Hollow Sleepy Hollow, New York, United States, 10591
    • State University of New York Upstate Medical University Syracuse, New York, United States, 13210
    • Montefiore Medical Center - Moses Campus The Bronx, New York, United States, 10467-2490
  • United States, North Carolina
    • UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599
    • Carolinas Medical Center/Levine Cancer Institute Charlotte, North Carolina, United States, 28203
    • Novant Health Presbyterian Medical Center Charlotte, North Carolina, United States, 28204
    • Carolinas Medical Center/Levine Cancer Institute-Pineville Charlotte, North Carolina, United States, 28210
    • Carolinas Medical Center/Levine Cancer Institute-University Charlotte, North Carolina, United States, 28262
    • Carolinas HealthCare System NorthEast Concord, North Carolina, United States, 28025
    • Duke University Medical Center Durham, North Carolina, United States, 27710
    • CaroMont Regional Medical Center Gastonia, North Carolina, United States, 28054
    • Cone Health Cancer Center Greensboro, North Carolina, United States, 27403
    • East Carolina University Greenville, North Carolina, United States, 27858
    • Matthews Radiation Oncology Center Matthews, North Carolina, United States, 28105
    • Carolinas HealthCare System Union Monroe, North Carolina, United States, 28112
    • South Atlantic Radiation Oncology Supply, North Carolina, United States, 28462
    • Coastal Carolina Radiation Oncology Wilmington, North Carolina, United States, 28401
  • United States, North Dakota
    • Sanford Bismarck Medical Center Bismarck, North Dakota, United States, 58501
  • United States, Ohio
    • Summa Akron City Hospital/Cooper Cancer Center Akron, Ohio, United States, 44304
    • Akron General Medical Center Akron, Ohio, United States, 44307
    • Summa Barberton Hospital Barberton, Ohio, United States, 44203
    • UHHS-Chagrin Highlands Medical Center Beachwood, Ohio, United States, 44122
    • Aultman Health Foundation Canton, Ohio, United States, 44710
    • Geaugra Hospital Chardon, Ohio, United States, 44024
    • University of Cincinnati/Barrett Cancer Center Cincinnati, Ohio, United States, 45219
    • Good Samaritan Hospital - Cincinnati Cincinnati, Ohio, United States, 45220
    • Bethesda North Hospital Cincinnati, Ohio, United States, 45242
    • Case Western Reserve University Cleveland, Ohio, United States, 44106
    • Cleveland Clinic Cancer Center/Fairview Hospital Cleveland, Ohio, United States, 44111
    • Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195
    • Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210
    • The Mark H Zangmeister Center Columbus, Ohio, United States, 43219
    • Mount Carmel Health Center West Columbus, Ohio, United States, 43222
    • Delaware Radiation Oncology Delaware, Ohio, United States, 43015
    • Cleveland Clinic Cancer Center Independence Independence, Ohio, United States, 44131
    • Hillcrest Hospital Cancer Center Mayfield Heights, Ohio, United States, 44124
    • Summa Health Center at Lake Medina Medina, Ohio, United States, 44256
    • Lake University Ireland Cancer Center Mentor, Ohio, United States, 44060
    • Southwest General Health Center Ireland Cancer Center Middleburg Heights, Ohio, United States, 44130
    • University Hospitals Parma Medical Center Parma, Ohio, United States, 44129
    • North Coast Cancer Care Sandusky, Ohio, United States, 44870
    • Cleveland Clinic Cancer Center Strongsville Strongsville, Ohio, United States, 44136
    • University Pointe West Chester, Ohio, United States, 45069
    • UHHS-Westlake Medical Center Westlake, Ohio, United States, 44145
    • Cleveland Clinic Wooster Family Health and Surgery Center Wooster, Ohio, United States, 44691
  • United States, Oklahoma
    • Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma, United States, 73505
    • University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, United States, 73104
    • Mercy Hospital Oklahoma City Oklahoma City, Oklahoma, United States, 73120
    • Natalie Warren Bryant Cancer Center at Saint Francis Tulsa, Oklahoma, United States, 74136
  • United States, Oregon
    • Willamette Valley Cancer Center Eugene, Oregon, United States, 97401
    • Legacy Mount Hood Medical Center Gresham, Oregon, United States, 97030
    • Compass Oncology Rose Quarter Portland, Oregon, United States, 97227
    • Kaiser Permanente Northwest Portland, Oregon, United States, 97227
    • Mid-Columbia Medical Center/Celilo Cancer Center The Dalles, Oregon, United States, 97058
  • United States, Pennsylvania
    • Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania, United States, 18103
    • UPMC-Heritage Valley Health System Beaver Beaver, Pennsylvania, United States, 15009
    • Saint Luke's University Hospital-Bethlehem Campus Bethlehem, Pennsylvania, United States, 18015
    • Northeast Radiation Oncology Center Dunmore, Pennsylvania, United States, 18512
    • Ephrata Cancer Center Ephrata, Pennsylvania, United States, 17522
    • The Regional Cancer Center Erie, Pennsylvania, United States, 16505
    • Fox Chase Cancer Center Buckingham Furlong, Pennsylvania, United States, 18925
    • Adams Cancer Center Gettysburg, Pennsylvania, United States, 17325
    • UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg, Pennsylvania, United States, 15601
    • PinnacleHealth Cancer Center-Community Campus Harrisburg, Pennsylvania, United States, 17109
    • Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850
    • Lancaster General Hospital Lancaster, Pennsylvania, United States, 17604
    • Holy Redeemer Hospital and Medical Center Meadowbrook, Pennsylvania, United States, 19046
    • Intercommunity Cancer Center Monroeville, Pennsylvania, United States, 15146
    • UPMC-Coraopolis/Heritage Valley Radiation Oncology Moon, Pennsylvania, United States, 15108
    • Allegheny Valley Hospital Natrona Heights, Pennsylvania, United States, 15065
    • University of Pennsylvania/Abramson Cancer Center Philadelphia, Pennsylvania, United States, 19104
    • Pennsylvania Hospital Philadelphia, Pennsylvania, United States, 19107
    • Thomas Jefferson University Hospital Philadelphia, Pennsylvania, United States, 19107
    • Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111
    • Temple University Hospital Philadelphia, Pennsylvania, United States, 19140
    • Allegheny General Hospital Pittsburgh, Pennsylvania, United States, 15212
    • UPMC-Magee Womens Hospital Pittsburgh, Pennsylvania, United States, 15213
    • UPMC-Saint Margaret Pittsburgh, Pennsylvania, United States, 15215
    • UPMC-Shadyside Hospital Pittsburgh, Pennsylvania, United States, 15232
    • Reading Hospital West Reading, Pennsylvania, United States, 19611
    • Wexford Health and Wellness Pavilion Wexford, Pennsylvania, United States, 15090
    • WellSpan Health-York Hospital York, Pennsylvania, United States, 17403
  • United States, Rhode Island
    • Rhode Island Hospital Providence, Rhode Island, United States, 02903
    • Radiation Oncology Associates Incorporated Providence, Rhode Island, United States, 02904
    • Women and Infants Hospital Providence, Rhode Island, United States, 02905
    • Kent County Hospital Warwick, Rhode Island, United States, 02886
  • United States, South Carolina
    • Roper Hospital Charleston, South Carolina, United States, 29401
    • Bon Secours Saint Francis Hospital Charleston, South Carolina, United States, 29414
    • Medical University of South Carolina Charleston, South Carolina, United States, 29425
    • Georgetown Hospital System Georgetown, South Carolina, United States, 29440
    • Greenville Health System Cancer Institute-Andrews Greenville, South Carolina, United States, 29605
    • Greenville Health System Cancer Institute-Faris Greenville, South Carolina, United States, 29605
    • Saint Francis Cancer Center Greenville, South Carolina, United States, 29607
    • Greenville Health System Cancer Institute-Eastside Greenville, South Carolina, United States, 29615
    • Greenville Health System Cancer Institute-Greer Greer, South Carolina, United States, 29650
    • Gibbs Cancer Center-Pelham Greer, South Carolina, United States, 29651
    • The Radiation Oncology Center-Hilton Head/Bluffton Hilton Head Island, South Carolina, United States, 29926
    • Greenville Health System Cancer Institute-Seneca Seneca, South Carolina, United States, 29672
    • Spartanburg Medical Center Spartanburg, South Carolina, United States, 29303
    • Greenville Health System Cancer Institute-Spartanburg Spartanburg, South Carolina, United States, 29307
    • Lexington Medical Center West Columbia, South Carolina, United States, 29169
  • United States, South Dakota
    • Avera Cancer Institute Sioux Falls, South Dakota, United States, 57105
    • Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota, United States, 57117-5134
  • United States, Tennessee
    • The West Clinic - Wolf River Germantown, Tennessee, United States, 38138
    • Thompson Cancer Survival Center Knoxville, Tennessee, United States, 37916
    • Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee, United States, 38120
    • Vanderbilt University/Ingram Cancer Center Nashville, Tennessee, United States, 37232
  • United States, Texas
    • Texas Cancer Center Abilene, Texas, United States, 79606
    • The Don and Sybil Harrington Cancer Center Amarillo, Texas, United States, 79106
    • Texas Oncology-Arlington South Arlington, Texas, United States, 76014
    • Texas Oncology-Austin Midtown Austin, Texas, United States, 78705
    • Texas Oncology - Central Austin Cancer Center Austin, Texas, United States, 78731
    • Texas Oncology - South Austin Cancer Center Austin, Texas, United States, 78745
    • Texas Oncology Bedford Bedford, Texas, United States, 76022
    • Parkland Memorial Hospital Dallas, Texas, United States, 75235
    • UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas, United States, 75390
    • Texas Oncology-Flower Mound Flower Mound, Texas, United States, 75028
    • The Klabzuba Cancer Center Fort Worth, Texas, United States, 76104
    • Memorial Hermann Memorial City Medical Center Houston, Texas, United States, 77024
    • M D Anderson Cancer Center Houston, Texas, United States, 77030
    • The Methodist Hospital System Houston, Texas, United States, 77030
    • MD Anderson Regional Care Center-Katy Houston, Texas, United States, 77094
    • Doctor's Hospital of Laredo Laredo, Texas, United States, 78041
    • Covenant Medical Center-Lakeside Lubbock, Texas, United States, 79410
    • University Medical Center Lubbock, Texas, United States, 79415
    • Texas Tech University Health Sciences Center-Lubbock Lubbock, Texas, United States, 79430
    • MD Anderson Regional Care Center-Bay Area Nassau Bay, Texas, United States, 77058
    • Texas Oncology-Plano West Plano, Texas, United States, 75093
    • Scott and White Healthcare Round Rock Round Rock, Texas, United States, 78665
    • Texas Oncology - Round Rock Cancer Center Round Rock, Texas, United States, 78681
    • University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229
    • Texas Cancer Center-Sherman Sherman, Texas, United States, 75090
    • MD Anderson Regional Care Center-Sugar Land Sugar Land, Texas, United States, 77478
    • Texas Oncology Cancer Center Sugar Land Sugar Land, Texas, United States, 77479
    • Scott and White Memorial Hospital Temple, Texas, United States, 76508
    • MD Anderson Regional Care Center-The Woodlands The Woodlands, Texas, United States, 77384
    • Deke Slayton Cancer Center Webster, Texas, United States, 77598
  • United States, Utah
    • Intermountain Medical Center Murray, Utah, United States, 84107
    • Utah Valley Regional Medical Center Provo, Utah, United States, 84604
    • Huntsman Cancer Institute/University of Utah Salt Lake City, Utah, United States, 84112
    • South Jordan Health Center South Jordan, Utah, United States, 84009
  • United States, Vermont
    • Norris Cotton Cancer Center-North Saint Johnsbury, Vermont, United States, 05819
  • United States, Virginia
    • Inova Alexandria Hospital Alexandria, Virginia, United States, 22304
    • University of Virginia Cancer Center Charlottesville, Virginia, United States, 22908
    • Inova Fairfax Hospital Falls Church, Virginia, United States, 22042
    • Augusta Health Cancer Center Fishersville, Virginia, United States, 22939
    • Mary Washington Hospital Fredericksburg, Virginia, United States, 22401
    • Sentara Cancer Institute at Sentara CarePlex Hospital Hampton, Virginia, United States, 23666
    • Sentara Norfolk General Hospital Norfolk, Virginia, United States, 23507
    • Naval Medical Center - Portsmouth Portsmouth, Virginia, United States, 23708-2197
    • Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298
    • Oncology and Hematology Associates of Southwest Virginia Roanoke, Virginia, United States, 24014
    • Sentara Virginia Beach General Hospital Virginia Beach, Virginia, United States, 23454
  • United States, Washington
    • MultiCare Auburn Medical Center Auburn, Washington, United States, 98001
    • Overlake Hospital Medical Center Bellevue, Washington, United States, 98004
    • Harrison Medical Center Bremerton, Washington, United States, 98310
    • Virginia Mason Federal Way Medical Center Federal Way, Washington, United States, 98002
    • Tacoma/Valley Radiation Oncology Centers-Gig Harbor Gig Harbor, Washington, United States, 98332
    • MultiCare Gig Harbor Medical Park Gig Harbor, Washington, United States, 98335
    • Tri-Cities Cancer Center Kennewick, Washington, United States, 99336
    • Skagit Valley Hospital Regional Cancer Care Center Mount Vernon, Washington, United States, 98273
    • MultiCare Good Samaritan Hospital Puyallup, Washington, United States, 98372
    • Tacoma/Valley Radiation Oncology Centers-Puyallup Puyallup, Washington, United States, 98372
    • Virginia Mason Medical Center Seattle, Washington, United States, 98101
    • Fred Hutchinson Cancer Research Center Seattle, Washington, United States, 98109
    • Seattle Cancer Care Alliance Seattle, Washington, United States, 98109
    • University of Washington Medical Center Seattle, Washington, United States, 98195
    • Cancer Care Northwest - Spokane South Spokane, Washington, United States, 99202
    • Spokane Valley Cancer Center-Mayfair Spokane, Washington, United States, 99208
    • MultiCare Tacoma General Hospital Tacoma, Washington, United States, 98405
    • Northwest Medical Specialties PLLC Tacoma, Washington, United States, 98405
    • Saint Joseph Medical Center Tacoma, Washington, United States, 98405
    • Tacoma/Valley Radiation Oncology Centers-Saint Joe's Tacoma, Washington, United States, 98405
    • Compass Oncology Vancouver Vancouver, Washington, United States, 98684
  • United States, West Virginia
    • West Virginia University Healthcare Morgantown, West Virginia, United States, 26506
  • United States, Wisconsin
    • Langlade Hospital and Cancer Center Antigo, Wisconsin, United States, 54409
    • Fox Valley Surgical Associates Limited Appleton, Wisconsin, United States, 54911
    • Radiology Associates of Appleton/ThedaCare Regional Medical Center Appleton, Wisconsin, United States, 54911
    • ThedaCare Regional Cancer Center Appleton, Wisconsin, United States, 54911
    • Sacred Heart Hospital Eau Claire, Wisconsin, United States, 54701
    • Aurora Cancer Care-Grafton Grafton, Wisconsin, United States, 53024
    • Saint Vincent Hospital Cancer Center Green Bay Green Bay, Wisconsin, United States, 54301
    • Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay, Wisconsin, United States, 54303
    • Aurora BayCare Medical Center Green Bay, Wisconsin, United States, 54311
    • UW Cancer Center Johnson Creek Johnson Creek, Wisconsin, United States, 53038
    • Aurora Cancer Care-Kenosha South Kenosha, Wisconsin, United States, 53142
    • Gundersen Lutheran Medical Center La Crosse, Wisconsin, United States, 54601
    • Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin, United States, 54601
    • University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792
    • Marshfield Clinic Marshfield, Wisconsin, United States, 54449
    • Saint Joseph's Hospital Marshfield, Wisconsin, United States, 54449
    • Community Memorial Hospital Menomonee Falls, Wisconsin, United States, 53051
    • Aurora Saint Luke's Medical Center Milwaukee, Wisconsin, United States, 53215
    • Froedtert and the Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226
    • Aurora Sinai Medical Center Milwaukee, Wisconsin, United States, 53233
    • Marshfield Clinic-Minocqua Center Minocqua, Wisconsin, United States, 54548
    • Surgical Associates of Neenah SC Neenah, Wisconsin, United States, 54956
    • ProHealth Oconomowoc Memorial Hospital Oconomowoc, Wisconsin, United States, 53066
    • Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin, United States, 54904
    • Wheaton Franciscan Cancer Care - All Saints Racine, Wisconsin, United States, 53405
    • Marshfield Clinic-Rice Lake Center Rice Lake, Wisconsin, United States, 54868
    • Saint Michael's Hospital Stevens Point, Wisconsin, United States, 54481
    • Marshfield Clinic Stevens Point Center Stevens Point, Wisconsin, United States, 54482
    • Aurora Medical Center in Summit Summit, Wisconsin, United States, 53066
    • Vince Lombardi Cancer Clinic-Two Rivers Two Rivers, Wisconsin, United States, 54241
    • ProHealth Waukesha Memorial Hospital Waukesha, Wisconsin, United States, 53188
    • UW Cancer Center at ProHealth Care Waukesha, Wisconsin, United States, 53188
    • Aspirus Regional Cancer Center Wausau, Wisconsin, United States, 54401
    • Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin, United States, 53226
    • Aurora West Allis Medical Center West Allis, Wisconsin, United States, 53227
    • The Alyce and Elmore Kraemer Cancer Care Center West Bend, Wisconsin, United States, 53095
    • Diagnostic and Treatment Center Weston, Wisconsin, United States, 54476
  • Canada, Alberta
    • Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2
    • Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2
  • Canada, Manitoba
    • CancerCare Manitoba Winnipeg, Manitoba, Canada, R3E 0V9
  • Canada, New Brunswick
    • Atlantic Health Sciences Corporation-Saint John Regional Hospital Saint John, New Brunswick, Canada, E2L 4L2
  • Canada, Ontario
    • University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9
  • Canada, Quebec
    • CIUSSSEMTL-Hopital Maisonneuve-Rosemont Montreal, Quebec, Canada, H1T 2M4
    • McGill University Department of Oncology Montreal, Quebec, Canada, H2W 1S6
    • Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2
    • CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec City, Quebec, Canada, G1R 2J6
    • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Sherbrooke, Quebec, Canada, J1H 5N4
  • Canada, Saskatchewan
    • Allan Blair Cancer Centre Regina, Saskatchewan, Canada, S4T 7T1
    • Saskatoon Cancer Centre Saskatoon, Saskatchewan, Canada, S7N 4H4
  • Ireland, Co Dublin
    • Saint Lukes Hospital Dublin, Co Dublin, Ireland, 6
  • Ireland, Co Galway
    • University College Hospital Galway Galway, Co Galway, Ireland,
  • Israel,
    • Chaim Sheba Medical Center Tel Hashomer, , Israel, 52621
  • Japan, Aoba-ku
    • Tohoku University School of Medicine Sendai, Aoba-ku, Japan, 980-8574
  • Japan, Hokkaido
    • Hokkaido University Hospital Sapporo, Hokkaido, Japan, 060-8648
  • Japan, Hyogo
    • Hyogo Cancer Center Akashi-city, Hyogo, Japan, 673-8558
  • Japan, Iwate
    • Iwate Medical University School of Medicine Morioka, Iwate, Japan, 020-8505
  • Japan, Maebashi
    • Gunma University Hospital Gunma, Maebashi, Japan, 371-8511
  • Japan, Niigata
    • Niigata University Medical and Dental Hospital Niigata City, Niigata, Japan, 951-8520
  • Japan,
    • Shikoku Cancer Center Matsuyama, , Japan, 791-0280
    • Saitama Medical University International Medical Center Saitama, , Japan, 350-1298
  • Korea, Republic of,
    • Yonsei University Health System-Severance Hospital Seoul, , Korea, Republic of, 120-752
  • Puerto Rico,
    • San Juan City Hospital San Juan, , Puerto Rico, 00936

Sponsors and Collaborators

NSABP Foundation Inc

National Cancer Institute (NCI)

Radiation Therapy Oncology Group

More Information

No publications provided

Responsible Party: Sponsor
ClinicalTrials.gov Identifier: NCT01872975
Other Study ID Numbers: NCI-2012-03198
Study First Received:
Last Updated:
Health Authority:

Additional relevant MeSH terms:

Breast Neoplasms

Next Steps


If you are interested in this protocol or in other treatment options at Massachusetts General Hospital, please Request a Consultation.







ClinicalTrials.gov processed this data on May 30, 2019